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BACKGROUND: Obesity, assessed by body mass index (BMI), is an established risk factor for 13 cancers. We aimed to identify further potential obesity-related cancers and to quantify their association with BMI relative to that of established obesity-related cancers.METHODS: Using Cox regression models on 4,142,349 individuals in Sweden (mean age 27.1 years at weight measurement), we calculated hazar
Aims: Type 2 diabetes (T2D) patients with a clinical phenotype characterized by a high degree of insulin resistance are at increased risk of chronic kidney disease (CKD). We previously demonstrated that the endothelin receptor antagonist (ERA) atrasentan reduced insulin resistance in T2D. In this study, we compared the effect of atrasentan on insulin resistance across different phenotypic clusters
The first ICDRG (International Contact Dermatitis Research Group) classification of patch test reactions was published in 1970. With this classification, many weak reactions were classified as allergic reactions. A second classification was therefore implemented one decade later on behalf of the ICDRG and the North American Contact Dermatitis Group. This classification was adopted by the European
OBJECTIVES: It remains unclear whether antenatal SARS-CoV-2 exposure affects subsequent infant neurodevelopment. We aimed to investigate the association between antenatal maternal SARS-CoV-2 infection and neurodevelopment in four-month-old infants.METHODS: Data was collected within the prospective multicenter COVID-19 during pregnancy and early childhood study, COPE (NCT04433364). Infants exposed
Across different domains, justice is considered either from a perspective concerning mind-independent features of a situation or from a perspective related to mind-dependent motives, traits or emotions. Although these approaches have generated valuable insights, they remain largely disconnected from each other. What is missing is an integrative framework that can explain how the objective features
UNLABELLED: Pectobacterium brasiliense ( Pbr) is known to be one of the most virulent Pectobacterium species and is generally widely distributed across the globe, especially known for causing soft rot in potato-tubers and black leg in potato-plants. Currently no treatment mechanism exists, and many studies have focused on alternative treatment approaches such as biocontrol agents. Several stu
Risk assessment of pesticide impacts on remote ecosystems makes use of model-estimated degradation in air. Recent studies suggest these degradation rates to be overestimated, questioning current pesticide regulation. Here, we investigated the concentrations of 76 pesticides in Europe at 29 rural, coastal, mountain, and polar sites during the agricultural application season. Overall, 58 pesticides
Introduction: Older people with intellectual disabilities (ID) have higher levels of comorbidities and overall healthcare utilization than the general population. A known healthcare need would imply high levels of planned healthcare, while unplanned healthcare could be a sign of unmet healthcare needs. Thus, to understand if older people with ID are receiving the healthcare they need, different ty
Background: Cardiovascular disease and type 2 diabetes are among the largest public health challenges in Sweden. Research indicates that a healthy lifestyle can prevent most cases. The health dialogue is an evidence-based public health programme for primary care with positive results in several regions of Sweden. This study aimed to describe health care professionals’ experiences and perceptions o
Background/Objective: Growth and obesity have been associated with increased risk of islet autoimmunity (IA) and progression to type 1 diabetes. We aimed to estimate the effect of energy-yielding macronutrient intake on the development of IA through BMI. Research Design and Methods: Genetically at-risk children (n = 5,084) in Finland, Germany, Sweden, and the USA, who were autoantibody negative at
Background: Allergic contact dermatitis (ACD) caused by hexavalent chromium (Cr(VI)) is often severe and difficult to treat. The content of Cr(VI) in cement can be reduced by, for example, addition of iron(II) sulfate. Since 2005 the content of Cr(VI) in cement is regulated in the EU Directive 2003/53/EC and must not exceed 2 ppm. Since this regulation came into force, ACD caused by cemen
Background: Happiness is often conceptualized as subjective well-being, which comprises people's evaluations of emotional experiences (i.e., the affective dimension: positive and negative feelings and emotions) and judgements of a self-imposed ideal (i.e., the cognitive dimension: life satisfaction). Recent research has established these two dimensions as primary parts of a higher order factor. Ho
INTRODUCTION: The prophylactic regimen in children with severe haemophilia is suggested in various publications and guidelines. Few data exist on its implementation in clinical practice.AIM: To investigate the implementation of primary prophylaxis based on real-life data from PedNet during the last 20 years.METHODS: All children from the PedNet cohort (n = 1260) with severe haemophilia A (SHA) or
Deciphering the metamorphic evolution of the roots of mountain belts is essential for understanding deep tectonic processes involved in mountain building. The Sveconorwegian orogen in southwestern Scandinavia, formed during the Rodinia assembly in the transition between the Mesoproterozoic and Neoproterozoic Eras, has been exhumed and provides access to interior deep structural levels of the ancie
BACKGROUND: Streptococcus bovis/equinus complex (SBSEC) comprise several species and subspecies and is a common cause of infective endocarditis (IE). S. gallolyticus subsp. gallolyticus (Sg gallolyticus) accounts for a majority of SBSEC IE, but the risk of IE for other subspecies is largely unknown. We aimed to investigate the clinical presentation of bacteraemia, and proportion of patients with I
The Commission has put forth a proposal for a Regulation on a Common European Law of Sales (CESL). It is envisaged – as of now – as an optional second regime within each member state‘s law, electable for transnational consumer contracts and contracts among traders, as long as one of them is a small or medium-sized enterprise. The intention is to provide contractors with a level playground of one l
The aim of this study is to examine the role of knowledge societies, so called epistemic communities, in the problem-defining and initial decision-making stages of the EU policymaking process leading to a Proposal for amendment of Directive 2003/87/EC establishing the European Emission Trading System (EU ETS). Specifically in the decision to drastically increase the amount of allowances auctioned
Russia’s military aggression against Ukraine has prompted an extensive sanctions regime by the European Union (EU), which now plays a significant role in shaping the practice of international arbitration. These sanctions have not only made it more difficult to enforce international contracts, but have also placed lawyers in a difficult position, caught between legal obligations and ethical conside
