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Although the calcineurin inhibitors (CNI) cyclosporine (CsA) and tacrolimus are highly effective immunosuppressants, they are associated with serious side effects. There is great interest in immunosuppressive regimens that permit reduction or elimination of CNIs, while maintaining adequate immunosuppression and acceptable acute rejection rates. Patients (n = 536) receiving their first renal allogr
The content of the globular domains G1, G2 and G3 on the core protein of high-density (A1D1) aggrecan isolated from newborn and mature bovine cartilage and from cultures of bovine chondrocytes was examined. Quantitation based on the 220 nm absorbance of tryptic marker peptides from each domain isolated by reversed-phase HPLC showed that while the content of G1 and G2 was essentially the same for a
After birth, the gastrointestinal (GI) tract undergoes vast structural and functional adaptations to be able to digest mother's milk and later, during the weaning period, solid food. Studies on germ-free animals have shown the role of the gut microbiota for stimulating GI maturation, but which groups are involved is unclear. In the present study, we administered the probiotic bacterium, Lactobacil
Ab initio calculations of low-lying electronic states of CrH are presented, including potential energies, dipole and transition dipole moment (TDM) functions, and radiative lifetimes for X (6)Sigma(+), A (6)Sigma(+), 3 (6)Sigma(+), 1 (6)Pi, 2 (6)Pi, 3 (6)Pi, and (6)Delta. Calculation of dynamic correlation effects was performed using the multistate complete active space second-order perturbation m
In this work a rotating disc method was developed for studying the dissolution process of "bimodal" polymer tablets, whose dissolution rates have been tuned by mixing low-molecular weight and high-molecular weight samples of poly(ethylene oxide) in various proportions. The tablets were prepared along different routes, by mixing the polymer fractions as powders or by mixing on a molecular level so
Relapsing polychondritis ( RP) is an autoimmune disease that affects extra-articular cartilage. Matrilin-1-induced relapsing polychondritis (MIRP) is a model for RP and is useful for studies of the pathogenic mechanisms in this disease. There are indications that the major histocompatibility complex (MHC) class II plays a major role in RP, since DR4(+) patients are more commonly affected than cont
This chapter neither seeks to deny nor diminish the potential of ILP, nor the Danish Police’s ILP fervor for that matter. The practical ups (and downs) of ILP and similar policing methodologies have already been dissected in many of the publications cited earlier (see also, Egbert and Leese, 2021). Rather, this chapter takes a second look at the convictions that underpins ILP work and the Danish p
Low-grade inflammation and arterial stiffness are key factors in the development of vascular aging. However, the interplay between arterial stiffness and inflammation for cardiovascular (CV) disease is unclear. Aortic pulse wave velocity (aPWV) and the inflammatory markers, high-sensitivity C-reactive protein (CRP) and orosomucoid, were measured in 2710 participants (median age: 72 years). These p
BACKGROUND: Red cell distribution width (RDW) reflects heterogeneity of the erythrocyte volumes. High RDW is a novel risk marker, which has been associated with mortality and morbidity both from cardiovascular and respiratory diseases, but the association between RDW and measures of lung function in the general population remains unclear.METHODS: The associations of RDW with spirometry, diffusing
Popular Abstract in Swedish När födan efter en måltid kommer ned i tunntarmen, utsöndras ett protein som heter cholecystokinin, förkortat CCK, ifrån tarmslemhinnan till blodet. Ett ämne som frisätts på detta sätt till blodcirkulationen för att påverka celler i andra organ i kroppen kallas för hormon. CCK påverkar gallblåsan till att dra ihop sig och tömma sitt innehåll samtidigt som bukspottkörtelCholecystokinin (CCK) is known to exert secretory and trophic effects on the pancreas. Its release from the intestinal mucosa is regulated by pancresic proteases in the small intestine. However, knowledge about the type of responding exocrine cells and the time course of events during stimulation with CCK is lacking. Further, the role of CCK in the regulation of growth in other digestive organs is
There is a clearly visible dichotomy in architectural sustainability approaches today. While there are several housing solutions available fulfilling sustainability criteria, most of these follow the high-tech industrial approach. In main-stream architecture these are often referred to as “green” or “sustainable” architecture. “Natural” or “regenerative” building practices stand at the other end o
This study investigates how the seven core resilience principles are integrated into assessments of forest system resilience to natural or human-induced disturbances across engineering, ecological, and social-ecological resilience concepts. Following PRISMA guidelines, a literature search in the Web of Science database using the keywords “resilience”, “forest” and “ecosystem services” yielded 1828
Background: Schistosomiasis is a snail-borne disease affecting over 200 million people worldwide. Despite dedicated control efforts and effective diagnostic tools, schistosomiasis remains prevalent. Novel and sustainable control measures are urgently needed. Bacteria might offer such a solution as links between bacteria, disease resistance and transmission potential of intermediate hosts have been
Although rising inequality in sub-Saharan Africa has revived debates on the distributional effects of government tax and expenditure policies, there are relatively few long-term empirical studies on this issue. This chapter examines how government fiscal policies—both taxation and public spending—have evolved and shaped inequality trends in colonial and postcolonial Ghana. It finds that fiscal pol
In recent years, there has been a growing scholarly interest in the cultural and political significance of joyful, positive and nostalgic memories and forms of remembrance. Without downplaying the role of trauma and oppression in the mnemonic makeup of contemporary societies, memory scholars have increasingly pointed to the co-existence, or parallel existence, of brighter recollections of the past
