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RATIONALE: The alveolar pathology in chronic obstructive pulmonary disease (COPD) involves antigen-driven immune events. However, the induction sites of alveolar adaptive immune responses have remained poorly investigated. OBJECTIVES: To explore the hypothesis that interfaces between the alveolar lumen and lymphoid aggregates (LAs) provide a structural basis for increased alveolar antigen uptake i
Total resection of glioblastoma multiform (GBM), the most common and aggressive malignant brain tumor, is challenging among other things due to difficulty in intraoperative discrimination between normal and residual tumor cells. This project demonstrates the potential of a system based on a combination of autofluorescence and diffuse reflectance spectroscopy to be useful as an intraoperative guidi
Popular Abstract in Swedish Proteoglykaner (PG), framför allt sådana som bär glykosaminoglykan-sidokedjor av heparansulfat (HS) typ, utgör multifunktionella receptorer på cellytan och i pericellulär matrix hos alla adherenta celler i högre organismer. HS-proteoglykaner är inblandade i många olika cellprocesser, bl.a. koagulation, celltillväxt, och aktivering av enzymer, antienzymer samt bindning tThe present investigation focuses on the role of HS metabolism in cell proliferation. The effect of the HS priming ß-D-xyloside, 2-(6-hydroxynaphthyl)-O-ß-D-xylopyranoside (Xyl-2-Nap-6-OH) on the proliferation of normal and transformed cells was studied. Xyl-2-Nap-6-OH inhibited growth of transformed cells to a significantly greater extent than normal cells. The growth inhibition exerted by the xy
Various studies have highlighted older persons' problems in potentially failing to keep pace with developments in information technology and the latest technologies that prevent physical and social loss. In contrast to such studies that treat users as static and technology as changing, it's important to understand the use of technology can change over time. For example, older persons have used tec
This paper describes the RTD project FRR (Friendly Rest Room) which is partly funded by the EU in the Quality of Life programme. The objective of the FRR project is (a) to create prototypes of more user friendly rest rooms for old persons and for persons
A joint analysis of five paternal half-sib Holstein families that were part of two different granddaughter designs (ADR- or Inra-design) was carried out for five milk production traits and somatic cell score in order to conduct a QTL confirmation study and to increase the experimental power. Data were exchanged in a coded and standardised form. The combined data set (JOINT-design) consisted of on
Background: Admission lactate and lactate clearance are implemented for risk stratification in sepsis and trauma. In out-of-hospital cardiac arrest, results regarding outcome and lactate are conflicting. Methods: This is a post-hoc analysis of the Target Temperature Management trial in which 950 unconscious patents after out-of-hospital cardiac arrest were randomized to a temperature intervention
The respiratory pathogen Moraxella catarrhalis is a human-specific commensal that frequently causes acute otitis media in children and stimulates acute exacerbations in chronic obstructive pulmonary disease patients. The exact molecular mechanisms defining host-pathogen interactions promoting pathogenesis are not clearly understood. Limited knowledge hampers vaccine and immunotherapeutic developme
Satellite remote sensing, with its unique synoptic coverage capabilities, can provide accurate and immediately valuable information on fire analysis and post-fire assessment, including estimation of burnt areas. In this study the potential for burnt area mapping of the combined use of Artificial Neural Network (ANN) and Spectral Angle Mapper (SAM) classifiers with Landsat TM satellite imagery was
This paper examines the impact of mutual inductance and parasitic capacitance on the phase-error performance for a class of CMOS quadrature voltage-controlled oscillators (QVCOs). Good agreement is found between theory, post-layout simulations, and measurement results. The QVCOs were implemented in a standard 0.35/spl mu/m CMOS process. All QVCOs display a center frequency of 2 GHz and a tuning ra
Hydrolysis rate constants of sludge at 35°C, 55°C, and 60°C were found to be 0.32 d-1, 0.44 d-1, and 0.50 d-1, respectively in pilot-scale experiments with digestion of municipal sludge in semi-continuously operated reactors. The hydrolysis rate constants as well as estimated chemical oxygen demand (COD) fractions in the feed were implemented in a mathematical model for anaerobic digestion similar
Anaerobic digestion would enable the energy potential of agricultural crop residues such as ley crops, sugar beet tops and straw to be harnessed in Sweden. These residues are so spread out that full utilisation of the potential by centralised slurry-based technology is difficult, its appearing that simple but effective high-solids reactor systems have a better chance of being economically viable o
The articles included in this thesis centre on what can be called the normative basis of risk analysis. Since risk analyses are decision procedures, they should adhere to norms of rational decision-making, and this they do. Most risk analysis schemes are built on a notion of the decision theoretic maxim that the goal of every decision is to maximize expected utility. However, for some thirty years
I detta avsnitt blir du uppmuntrad till att vara modig och att lära känna dig själv. Avsnittet handlar också hur du ska tänka om du inte vet vad du vill studera eller jobba med. Dessutom pratar vi om varför utbildning aldrig är bortkastad tid. Välkommen till denna podd, som heter "Från gymnasiet till universitet". Om du tänker söka in på universitet eller högskola för första gången– –och är osäker
We identify earnings impacts of exposure to an infant health intervention in Sweden, using individual-linked administrative data to trace potential mechanisms. Leveraging quasi-random variation in eligibility, we estimate that exposure was associated with higher test scores in primary school for boys and girls. However, only girls were more likely to score in the top quintile. Subsequent gains, in
