Filetype
OBJECTIVE: Screening of hypertension has been advocated for early detection and treatment. Severe hypertension (grade 3 hypertension) is a strong predictor for cardiovascular disease. This study aimed to evaluate not only the risk factors for developing severe hypertension, but also the prospective morbidity and mortality risk associated with severe hypertension in a population-based screening and
The purpose of this study was to investigate the effect of moisture on the heat transfer through clothing in relation to the water vapour resistance, type of underwear, location of the moisture and climate. This forms part of the work performed for work package 2 of the European Union THERMPROTECT project. Thermal manikin results of dry and wet heat loss are presented from different laboratories f
Enterohemorrhagic Escherichia coli (EHEC) is a highly virulent pathogen that can cause diarrhea and a life-threatening disease known as hemolytic uremic syndrome. EHEC possess an array of virulence factors that can exert severe consequences in the host. Shiga toxin constitutes a key virulence factor. Enteropathogenic Escherichia coli (EPEC) is a leading cause of infant diarrhea. EHEC and EPEC are
The neuronal endoplasmic reticulum (ER) contributes to many physiological and pathological processes in the brain. A subset of dendritic spines on hippocampal neurons contains ER that may contribute to synapse-specific intracellular signaling. Distribution of ER to spines is dynamic, but knowledge of the regulatory mechanisms is lacking. In live cell imaging experiments we now show that cultured h
To extend understanding of the genetic architecture and molecular basis of type 2 diabetes (T2D), we conducted a meta-analysis of genetic variants on the Metabochip, including 34,840 cases and 114,981 controls, overwhelmingly of European descent. We identified ten previously unreported T2D susceptibility loci, including two showing sex-differentiated association. Genomewide analyses of these data
While interplay between BRCA1 and AURKA-RHAMM-TPX2-TUBG1 regulates mammary epithelial polarization, common genetic variation in HMMR (gene product RHAMM) may be associated with risk of breast cancer in BRCA1 mutation carriers. Following on these observations, we further assessed the link between the AURKA-HMMR-TPX2-TUBG1 functional module and risk of breast cancer in BRCA1 or BRCA2 mutation carrie
In high-energy collisions, the spatio-temporal size of the particle production region can be measured using the Bose-Einstein correlations of identical bosons at low relative momentum. The source radii are typically extracted using two-pion correlations, and characterize the system at the last stage of interaction, called kinetic freeze-out. In low-multiplicity collisions, unlike in high-multiplic
Factor I (FI) is a serine protease that inhibits the complement system by cleaving activated C3 and C4 complement proteins, in the presence of cofactors. Mutations in the gene coding for FI have been identified in complete FI deficient- and atypical hemolytic uremic syndrome (aHUS) patients. The mutations were introduced in recombinantly expressed proteins, purified and analyzed in functional ass
The Zumaya section, northern Spain, is a suitable candidate to define the Global Stratotype Section and Point for the base of the Selandian Stage (Palaeocene) because of its excellent accessibility, exposure and stratigraphic continuity. Uncertainties exist, however, with regard to the stratigraphic horizon where to place the Danian/Selandian (D/S) boundary. Five potential stratigraphic horizons (
Objectives The systemic vasculitides are multiorgan diseases where early diagnosis and treatment can significantly improve outcomes. Robust nomenclature reduces diagnostic delay. However, key aspects of current nomenclature are widely perceived to be out of date, these include disease definitions, classification and diagnostic criteria. Therefore, the aim of the present work was to identify defici
Migratory movements in air or water are strongly affected by wind and ocean currents and an animal which does not compensate for lateral flow will be drifted from its intended direction of movement. We investigated whether arctic shorebirds during autumn migration in the region of South Sweden and the southern Baltic Sea compensate for wind drift or allow themselves to be drifted when approaching
As a growing problem in the world, negative emotions caused by awareness of environmental and climate changes are seen as one of the biggest mental health crises of our generation. This study examines young women's relationship to eco-emotions through a thematic analysis to improve understanding of how this group can be affected by these emotions and how they can live with them. Women and youn
This thesis examines the evolution of markups among the largest publicly listed firms in Sweden, represented by the OMXS30 index, during the period surrounding the COVID-19 pandemic from 2018 to 2024. The study assesses whether changes in firms’ pricing power contributed to Sweden’s inflationary and subsequent disinflationary dynamics. Using a microeconomic production function approach developed b
This paper provides insight into the experiences of female migrants from Honduras and how these are shaped by gender inequalities and discrimination in the context of forced migration. It also analyzes the role of social categories, relations, structures, and discourses in the creation of these experiences by applying an intersectional, social constructivist approach as the main critical lens for
Background: Apolipoprotein B (apoB) is a well-known risk factor for atherosclerosis. However, studies examining its relation to atrial fibrillation (AF) have produced conflicting results and suggested possible sex-specific differences. This study investigated the sex-specific associations between serum apoB concentrations and incident AF and offer insight into the inconsistencies in previous resea
Serglycin (SRGN) has been found overexpressed and secreted in glioblastoma (GBM), associated with tumorigenic signaling and poor prognosis. In this study, we aimed to elucidate the involvement of SRGN in the unfolded protein response (UPR), an oncogenic signaling pathway implicated in protein recycling and cell fate. Herein, we developed stably transduced LN-18shSCR GBM cells, expressing high leve
The exploration of tunable superconductivity in strongly correlated electron systems is a central pursuit in condensed matter physics, with implications for both fundamental understanding and potential applications. The Laves phase CeRu2, a pyrochlore compound, exhibits a three-dimensional (3D) kagome lattice type geometry giving rise to flat bands and degenerate Dirac points, where band structure
The interplay between superconductivity and charge or spin order is a key focus in condensed matter physics, with kagome lattice systems providing unique insights. The kagome superconductor LaRu3Si2 (Tc ≃ 6.5 K) features a characteristic kagome band structure and a hierarchy of charge order transitions at Tco,I ≃ 400 K and Tco,II ≃ 80 K, along with an additional transition at T* ≃ 35 K associated
The two-dimensional kagome lattice is an experimental playground for novel physical phenomena, from frustrated magnetism and topological matter to chiral charge order and unconventional superconductivity. A newly identified kagome superconductor, Ta2V3.1Si0.9 has recently gained attention for possessing a record high critical temperature, TC = 7.5 K for kagome metals at ambient pressure. In this s
