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Purpose Randomized clinical trials can provide strong evidence regarding effective treatment options. The quality of reporting and the type of outcome measures used are important when judging whether results justify change in clinical practice. The aim of this study was to assess the quality of reporting of randomized clinical trials related to treatment of upper-extremity disorders, published in

A combined quantum mechanical-statistical mechanical method has been used to study the behavior of the hydroxyl ion in water. The system is divided into three parts, a quantum core (the ion), 89 classical water molecules, and a dielectric continuum. The water molecules are represented using a polarizable potential. The first solvation shell consists of four water molecules, two linked by hydrogen

We point out that human low-Mr kininogen contains three cystatin-like sequences, rather than two, as had previously been thought. The protein was purified by affinity chromatography on carboxymethyl-papain-Sepharose, and subjected to limited proteolysis by trypsin and chymotrypsin. Fragments were isolated, and three corresponding to the individual cystatin-like domains were identified. By comparis

Wilms' tumor gene 1 (WT1) is a transcription factor involved in developmental processes. In adult hematopoiesis, only a small portion of early progenitor cells express WT1, whereas most leukemias show persistently high levels, suggesting an oncogenic role. We have previously characterized oncogenic BCR/ABL1 tyrosine kinase signaling pathways for increased WT1 expression. In this study, we show tha

BACKGROUND Tannins can bind to and precipitate protein by forming insoluble complexes resistant to fermentation and with a positive effect on protein utilisation by ruminants. Three protein types, Rubisco, rapeseed protein and bovine serum albumin (a single high-molecular weight protein), were used to test the effects of increasing concentrations of structurally different condensed tannins on prot

The anterior pituitary-derived hormone prolactin (PRL) signals through the PRL receptor (PRLR) and is important for female reproductive function in mammals. In contrast to the extensive studies of PRLR expression and regulation in human and mouse ovary and uterus, the mechanisms controlling the regulation of PRLR isoform expression in the fallopian tube are poorly understood. Because dynamic inter

The mucosal host defence discriminates pathogens from commensals, and prevents infection while allowing the normal flora to persist. Paradoxically, Toll-like receptors (TLR) control the mucosal defence against pathogens, even though the TLR recognise conserved molecules like LPS, which are shared between pathogens and commensals. This study proposes a mechanism of pathogen-specific mucosal TLR4 ac

We report a new strategy for on-fine monitoring of chemical reactions in ultrasonically levitated, nanoliter-sized droplets by Raman spectroscopy. A flow-through microdispenser connected to an automated flow injection system was used to dose picoliter droplets into the node of an ultrasonic trap. Taking advantage of the flow-through characteristics of the microdispenser and the versatility of the

Despite the great significance of geomorphologic-environmental data in different disciplines, there are sundry problems in relation to availability, accessibility and their applicability. Primarily the problems dealing with these data were investigated and then technical solutions to remove each of the above problems and how to manage geomorphologic-enviromnental data were suggested. The solution

This article focuses on expressions of bereavement and religious coping in medieval miracle stories from Sweden. The stories come from the collections of St. Birgitta (Bridget) of Sweden, the Blessed Bishop Nicolaus Hermanni (Sw. Nils Hermansson) of Linköping and the Blessed Katarina of Vadstena, and were recorded in the fourteenth and fifteenth centuries. Catherine M. Sanders’s modern five stages

This paper deals with the radiation protection of patients in diagnostic radiology and nuclear medicine. Modern equipment like CT, PET/CT and SPECT/CT are very important in the daily hospital routine and there is a risk to overuse them, which results in unnecessarily high doses both collectively and to individuals. Detailed referral criteria are needed as well as improved education and training in

Introduction. In recent years, there has been a growing interest in ethnographic research within the field of library and Information studies. Although ethnography has been used by information researchers for studying a wide variety of phenomena, discussions concerning methodological developments and directions, as well as ethnography’s wider applicability within the field are rare. Our intent is

ATP and ADP inhibit, in varying degrees, several dehydrogenases of the central carbon metabolism of Lactococcus lactis ATCC 19435 in vitro, i.e. glyceraldehyde-3-phosphate dehydrogenase (GAPDH), lactate dehydrogenase (LDH) and alcohol dehydrogenase (ADH). Here we demonstrate mixed inhibition for GAPDH and competitive inhibition for LDH and ADH by adenine nucleotides in single inhibition studies. T

The resistance of human immunodeficiency virus type 1 (HIV-1) to antibody-mediated immunity often prevents the detection of antibodies that neutralize primary isolates of HIV-1. However, conventional assays for antibody functions other than neutralization are suboptimal. Current methods for measuring the killing of virus-infected cells by antibody-dependent cell-mediated cytotoxicity (ADCC) are li

Three large-scale Echovirus (E) epidemics (E4,E16,E30), each differently associated to the acute development of diabetes related autoantibodies, have been documented in Cuba. The prevalence of islet cell autoantibodies was moderate during the E4 epidemic but high in the E16 and E30 epidemic. The aim of this study was to evaluate the effect of epidemic strains of echovirus on beta-cell lysis, beta-

The transition quadrupole moments. Q(t), of four weakly populated collective bands up to spin similar to 65h in Er-157,Er-158 have been measured to be similar to II eb demonstrating that these sequences are associated with large deformations. However, the data are inconsistent with calculated values from cranked Nilsson-Strutinsky calculations that predict the lowest energy triaxial shape to be as

Host defense peptides have recently gained much interest as novel anti-infectives owing to their ability to kill bacteria and simultaneously modulate host cell responses. The cationic host defense peptide GKY25 (GKYGFYTHVFRLKKWIQKVIDQFGE), derived from the C terminus of human thrombin, inhibits proinflammatory responses in vitro and in vivo, but the mode of action is unclear. In this study, we sho