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BackgroundMultigene expression assays for molecular subtypes and biomarkers can aid clinical management of early invasive breast cancer. Based on RNA-sequencing we aimed to develop single-sample predictor (SSP) models for conventional clinical markers, molecular intrinsic subtype and risk of recurrence (ROR).MethodsA uniformly accrued breast cancer cohort of 7743 patients with RNA-sequencing data
Amyloid fibrils are highly insoluble in neutral aqueous media of regular ionic strengths making solubilization a difficult task that normally calls for extremely harsh treatment. This is among the reasons for the routine employment of synthetic proteins in amyloid research, where the amylogenic components are needed. Here we describe a process for solubilizing amyloid in pure water that we adopted
Background: Cystatin C may add explanatory power for associations with mortality in combination with other filtration markers, possibly indicating pathways other than glomerular filtration rate (GFR). However, this has not been firmly established since interpretation of associations independent of measured GFR (mGFR) is limited by potential multicollinearity between markers of GFR. The primary aim
Background: Unhealthy diets, the rise of non-communicable diseases, and the declining health of the planet are highly intertwined, where food production and consumption are major drivers of increases in greenhouse gas emissions, substantial land use, and adverse health such as cancer and mortality. To assess the potential co-benefits from shifting to more sustainable diets, we aimed to investigate
Cellular-connected unmanned aerial vehicles (UAVs) have recently attracted a surge of interest in both academia and industry. Understanding the air-to-ground (A2G) propagation channels is essential to enable reliable and/or high-throughput communications for UAVs and protect the ground user equipments (UEs). In this contribution, a recently conducted measurement campaign for the A2G channels is in
Power control is becoming increasingly essential for the fifth-generation (5G) and beyond systems. An example use-case, among others, is the unmanned-aerial-vehicle (UAV) communications where the nearly line-of-sight (LoS) radio channels may result in very low signal-to-interference-plus-noise ratios (SINRs). The authors in (Chiang et al., 2007) proposed to efficiently and reliably solve this kind
In recent years, Unmanned Aerial Vehicles (UAVs)have been used extensively in military and civilian fields, making the research on cellular-connected UAVs a popular topic forFifth Generation (5G) and beyond communications. In order to support the increasing amount of applications, it is essential to evaluate the performance of UAV communications. In this work, the end-to-end delay, packet success
Millimeter-Wave (mmWave) massive multiple-input multiple-output (MIMO) has been considered as a key enabler for the fifth-generation (5G) communications. It is essential to design and test mmWave 5G devices under various realisticscenarios since the radio propagation channels pose intrinsic limitations on the performance. This requires emulating realistic dynamic mmWave channels in a reproducible
Spatially-coupled serially concatenated codes (SC-SCCS) are a class of turbo-like codes constructed by interconnecting a sequence of SCCS using a set of block permutors. At short block lengths, however, the bit-error-rate (BER) performance of SC-SCCS constructed by independent block permutors exhibits a high error floor. In this paper, we propose an alternative method for constructing SC-SCCS to m
Background: The scapular osseous free flap (SOFF) has become an important reconstructive option for complex head and neck defects. Postoperative donor site function is, however, an important consideration. The objective of this study was to prospectively investigate SOFF donor site morbidity and to relate the findings to hand dominance and neck dissection. Methods: Objective assessment included bi
Local pseudorandom generators are a class of fundamental cryptographic primitives having very broad applications in theoretical cryptography. Following Couteau et al.’s work at ASIACRYPT 2018, this paper further studies the concrete security of one important class of local pseudorandom generators, i.e., Goldreich’s pseudorandom generators. Our first attack is of the guess-and
Most recent programming languages include a collection framework as part of their standard library (or runtime). Examples are Java, C#, Python and Ruby. The Java Collection Framework provides a number of collection classes, some of which implement the same abstract data type, which makes them interchangeable. Developers can therefore choose between several functionally equivalent options. Since co
A system we denote Seg2Pose is presented which converts pixel coordinate tracks, represented by instance segmentation masks across multiple video frames, into world coordinate pose tracks, for road users seen by static surveillance cameras. The road users are bound to a ground surface represented by a number of 3D points and does not necessarily have to be perfectly flat. The system works with one
The increasing levels of software- and data-intensive driving automation call for an evolution of automotive soft-ware testing. As a recommended practice of the Verification and Validation (VV) process of ISO/PAS 21448, a candidate standard for safety of the intended functionality for road vehicles, simulation-based testing has the potential to reduce both risks and costs. There is a growing body
In this paper, we study the problem of error propagation in sliding window decoding (SWD) of spatially coupled LDPC (SC-LDPC) codes. A general decoder model that accounts for error propagation is proposed and analyzed, and the decoded block error rate (BLER) is calculated using the model. In order to improve the BLER performance under decoder error propagation conditions, adaptive variable node (V
Time-varying spatially coupled low-density parity-check (SC-LDPC) codes with very large period are characterized by significantly better error rate performance and girth properties than their time-invariant counterparts, but the number of parameters they require to be described is usually very large and unpractical. Time-invariant SC-LDPC codes, which can be seen as periodically time-varying codes
Background: Autonomous systems have received considerable attention from academia and are adopted by various industrial domains, such as automotive, avionics, etc. As many of them are considered safety-critical, testing is indispensable to verify their reliability and safety. However, there is no common standard for testing autonomous systems efficiently and effectively. Thus new approaches for te
This paper proposes a BP-based algorithm for sequential detection and estimation of MPC parameters based on radio signals. Under dynamic channel conditions with moving transmitter and/or receiver, the number of MPCs reflected from visible geometric features, the MPC dispersion parameters (delay, angle, Doppler frequency, etc), and the number of false alarm contributions are unknown and time-varyin
A platoon comprises a string of consecutive highly automated vehicles traveling together. Platooning allows for increased road utilization and reduced fuel consumption due to short inter-vehicular distances. Safety in terms of guaranteeing no rear-end collisions is of utmost importance for platooning systems to be deployed in practice. We compare how safely emergency braking can be handled by emer
