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Vitamin D analogues are in clinical use for prevention and treatment of secondary hyperparathyroidism (HPT) in chronic renal failure. Despite recent advances there is a need for vitamin D derivatives with maintained parathyroid hormone suppressive activity and less hypercalcemic and hyperphosphatemic toxicity. Here we show coincident increased expression of the vitamin D activating enzyme 25-hydro
Background: Unhealthy diets, the rise of non-communicable diseases, and the declining health of the planet are highly intertwined, where food production and consumption are major drivers of increases in greenhouse gas emissions, substantial land use, and adverse health such as cancer and mortality. To assess the potential co-benefits from shifting to more sustainable diets, we aimed to investigate
European Spallation Source (ESS) will deliver neutrons at high flux for use in diverse neutron scattering techniques. The neutron source facility and the scientific instruments will be located in Lund, and the Data Management and Software Centre (DMSC), in Copenhagen. A number of detector prototypes are being developed at ESS together with its European in-kind partners, for example: SoNDe, Multi-G
Objective: Homecare workers play a pivotal role in palliative care, but research on their experiences is limited. The aim of this study was to describe how homecare workers in Sweden experience their work in palliative homecare. Method: This qualitative study used open-ended interviews with a purposive sample of 15 homecare workers. The data was analysed by means of qualitative content analysis. R
Innovation and entrepreneurship are essential processes for human development, market growth, and technological breakthroughs, and it is vital for economic growth. Despite its importance, innovation is inherently difficult to measure and hence it is almost impossible for an individual or organization to know how they can improve their innovation output or claim that they are great at innovation. T
Introduction: Neoadjuvant chemotherapy (NAC) is an established treatment option for early breast cancer, potentially downstaging the tumor and increasing the eligibility for breast-conserving surgery (BCS). The primary aim of this study was to assess the rate of BCS after NAC, and the secondary aim was to identify predictors of application of BCS after NAC. Materials and methods: This was an obser
Objective: To implement artificial neural network (ANN) algorithms for noninvasive lymph node staging (NILS) to a decision support tool and facilitate the option to omit surgical axillary staging in breast cancer patients with low-risk of nodal metastasis. Methods: The NILS tool is a further development of an ANN prototype for the prediction of nodal status. Training and internal validation of the
The city of Milan stands today as a prominent model of sustainable urban development. Yet, beneath its allure lies a paradox: the quest for 'green' and 'smart' development has exacerbated privatization and fueled debates on green gentrification, social equity, and urban accessibility. This research explores the emerging impacts of large-scale green urbanization intervention in the
I denna studie undersöks legitimering av våld i amerikansk kontext. Syftet är att förstå och göra anspråk på att förklara legitimering av våld. Frågeställningen lyder; Hur legitimerar USA våld genom National security strategy från 2015 och i Barack Obamas state of union – tal från 2016? Vilka likheter eller skillnader finns i National security strategy från 2015 och Barack Obamas state of union –
The sparse identification of nonlinear dynamics (SINDy) algorithm enables us to discover nonlinear dynamical systems purely from data but is noise-sensitive, especially in low-data scenarios. In this work, we introduce an advanced method that integrates group sparsity thresholds with Earth Mover's distance-based similarity measures in order to enhance the robustness of identifying nonlinear dynami
Tool wear is one of the dominant factors that impacts the surface integrity of machined materials. Understanding the impact of tool wear on surface integrity is crucial in micromilling, due to the size of the features being machined and the cutting tools. Therefore, this work aims to analyse the impact of tool wear on surface integrity during the micromilling of Ti6Al4V. In this context, microslot
The purpose of this research is to conduct a critical study which focuses on getting deeper insights into in-application advertising, especially, to understand the details of making in-application advertising, and to develop the existing advertising model for applying to the in-application advertising specifically.
Climatic feedbacks and ecosystem impacts related to dust in the Arctic include direct radiative forcing (absorption and scattering), indirect radiative forcing (via clouds and cryosphere), semi-direct effects of dust on meteorological parameters, effects on atmospheric chemistry, as well as impacts on terrestrial, marine, freshwater, and cryospheric ecosystems. This review discusses our recent und
Out-of-distribution (OOD) detection is a crucial step in ensuring robustness and trustworthiness for deep learning (DL) models. This is particularly important for classification tasks in medical applications. Previous work has shown that point-of-care ultrasound (POCUS) imaging combined with a DL classification network could improve access to early breast cancer diagnosis. In this work, we investi
Den 30 oktober 2014 erkände Sverige Staten Palestina. Syftet med denna uppsats är att utifrån en folkrättslig metod undersöka de migrationsrättsliga konsekvenserna av detta. De frågor som aktualiseras i detta sammanhang är vilka som nu kan bedömas vara palestinska medborgare samt hur artikel 1 D och 1 C i flyktingkonventionen ska tillämpas till följd av erkännandet. Medborgarskapet får betydelse On October 30, 2014 Sweden recognized the State of Palestine. The purpose of this essay is to examine the legal consequences of this in the field of migration law by applying an international legal method. The questions arising in this context are which individuals that can be considered to be Palestinian citizens and how Article 1 D and 1 C in the Refugee Convention should be applied as a result
Genom en kvalitativ textanalys av tv-serien Lyckliga gatan undersöker denna uppsats hur hiphopgenren, likt andra musikgenrer före den, gått från att vara en subkultur till att bli en etablerad genre på det musikaliska fältet och sträckt sig från förorten till finkulturens scener. I serien Lyckliga gatan som hade premiär 2015, har beskrivits som hiphopens svar på Så mycket bättre, möter unga hiph
In February 2015 the British Parliament adopted the Counter-Terrorism and Security Act 2015 for the purpose of filling gaps in the previous counterterrorism legislations. The temporary restriction on travel measures thus introduced, target the increasing problem with so-called foreign fighters and consist of two elements. The power to seize and retain passports and/or travel documents entrusts a p
The aim of this study was to investigate the social worker's role and vision in the work with children and families who have a different language background. Social workers with families with several languages have expanded in Sweden in recent years, and that's why I think it is an interesting subject to study. I study about what room for maneuver they have in the meeting with the families
The aim of this study was to investigate the social worker's role and vision in the work with children and families who have a different language background. Social workers with families with several languages have expanded in Sweden in recent years, and that's why I think it is an interesting subject to study. I study about what room for maneuver they have in the meeting with the families
