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We investigated whether dementia risk factors were associated with prodromal Alzheimer's disease (AD) according to the International Working Group-2 and National Institute of Aging-Alzheimer's Association criteria, and with cognitive decline. A total of 1394 subjects with mild cognitive impairment from 14 different studies were classified according to these research criteria, based on cognitive pe
The spatial extent of ecological processes has consequences for the generation of ecosystem services related to them. However, management often fails to consider issues of scale when targeting ecological processes underpinning ecosystem services generation. Here, we present a framework for conceptualizing how the amount and spatial scale (here discussed in terms of extent) of management interventi
The trigeminal ganglion plays a key role in primary headache pathophysiology. Calcitonin gene-related peptide (CGRP) and CGRP receptors are expressed in trigeminal neurons that form C-fibers and A-fibers, respectively. In acute migraine and cluster headache attacks, there is release of CGRP into the cranial venous outflow. In addition, intravenous CGRP can induce migraine-like symptoms in migraine
Background/Aim. Hirschsprung's disease (HD) has a skewed gender distribution, with a female to male ratio of 1 : 4. This study aims to examine differences between boys and girls with HD regarding preoperative features and postoperative treatment and outcome. Method. The first part of the study was conducted as a retrospective review of all HD patients who underwent transanal endorectal pull-throug
This review article examines the differences in the approaches taken by economists and historians when interpreting social and economic change in the African past. It is argued that it is a mistake to assume that one discipline has supremacy over the other, let alone monopoly, when it comes to evaluating historical causes of African poverty. One of the shortcomings of the ‘New African Economic His
There is a growing trend to involve citizens in city development to make urban areas more sustainable and livable. The urban living labs approach offers a way to foster new collaborative, trans-disciplinary ways of thinking in urban planning and development, and provides a real-world testing ground for urban innovation and transformation. This handbook aims to bring open innovation and co-creation
Ionotropic glutamate receptors are tetrameric ligand gated ion channels that mediate in ux and ef ux of metal ions in response to glutamate. Positive allosteric modulators of the ionotropic glutamate receptor 2 (GluA2) are promising lead compounds for drugs against cognitive disorders. These compounds bind within the dimeric interface formed by the receptor ligand binding domains (LBDs) attenuatin
TheEl Niño SouthernOscillation(ENSO) isEarth's dominant source of interannual climate variability, but its response to globalwarming remainshighly uncertain1.To improve ourunder standing of ENSO's sensitivity to external climate forcing, it is paramount to determine its past behaviour by using palaeoclimate data and model simulations. Palaeoclimate records show that ENSO has varied considerably si
The last Catholic archbishop of Sweden to hold residence in his see at Uppsala, Johannes Magnus (1488-1544), was the author of a major work about Swedish history: the Historia de omnibus Gothorum Sueonumque regibus. Johannes Magnus left Sweden in 1526, spent the rest of his life away from his home country and eventually died in Rome, where his work was published posthumously in 1554. One reason fo
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Genetic polymorphisms are powerful model systems to study the maintenance of diversity in nature. In some systems, polymorphisms are limited to female coloration; these are thought to have arisen as a consequence of reducing male mating harassment, commonly resulting in negative frequency-dependent selection on female color morphs. One example is the damselfly Ischnura elegans, which shows three f
This study reports an aviary experiment aimed at determining what affects social dominance in the great tit (Parus major), especially why older birds (adults) in nature normally dominate younger ones (juveniles). When birds were matched with respect to age, prior residency determined dominance. Without a difference in prior residency older birds dominated younger ones. However, when juvenile birds
Bloggpost för New Review of Film and Television Studies "Short Cuts"-bloggBlog post for New Review of Film and Television Studies "Short Cuts" blog.
Business models like product-service systems (PSSs) often recognise different sustainability goals and are seen as solutions for the impacts of consumption and fast fashion, but there is a lack of evidence supporting the environmental claims of such business models for clothing. The research aimed to understand if rental clothing business models such as PSSs have the environmental benefits often p
