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The X-linked DDX3X gene encodes an ATP-dependent DEAD-box RNA helicase frequently altered in various human cancers, including melanomas. Despite its important roles in translation and splicing, how DDX3X dysfunction specifically rewires gene expression in melanoma remains completely unknown. Here, we uncover a DDX3X-driven post-transcriptional program that dictates melanoma phenotype and poor dise
Incentive alignment is discussed as one of the key factors for successful implementation of supply chain management. However, there is a lack of empirical research regarding implementation as well as evaluation of the effects of alignment mechanisms in practice. The purpose of this study is therefore to explore and describe the current practice and to identify gaps of Supply chain incentive alignm
This paper elucidates the increased need of correct calculations of thermal bridges for low/near zero energy buildings. The variability of the results from calculations of transmission losses for a building can be large if the calculation method within EN ISO 13789:2007 is not fully understood. A survey has been carried out which shows that there are no consensus in Sweden regarding how to define
Results from experiments on laboratory scale fedbatch processes are presented as well as analysis and design of the control system. The main reason for control is to track the drastic growth in feed demand during a cultivation. Variations in the amount and quality of the inocculum makes precalculated dosage schemes of limited value to obtain reproducible cultivation conditions. Two processes have
Drying is an important process in paper manufacturing, where steam heated cylinders are used to dry paper. Control of the moisture content is accomplished by adjusting the steam pressure in the cylinders. This paper presents a nonlinear dynamic model, based on heat and mass balances for steam, cylinder, and paper. It is implemented in the object-oriented modeling language Modelica and is used to e
An illustrated key is presented for the fifteen West Palearctic species and subspecies of the genera Ctenophora, Dictenidia, Phoroctenia and Tanyptera, with a review of their distribution and an overview of the recent literature for these taxa.
Penelope Delta was a writer of books for children in the beginning of the twentieth century in Greece. Delta was active when the national project was at its peak. Delta's own participation in the national project consisted of writing for children in a vernacular language and belonging to a group of intellectuals actively promoting modernization in other aspects than only political and technologica
Popular Abstract in Swedish Fetma, övervikt och allergi är ett problem i många delar av världen och förändringar i tarmens bakterieflora kan vara en av flera orsaker. Människan har tio gånger fler mikroorganismer än mänskliga celler. Flest mikroorganismer finns i tarmen och de brukar gemensamt kallas för tarmfloran. Många bakterier är helt oskadliga och en del är dessutom nödvändiga för att vi tilThe gastrointestinal tract of the foetus is considered sterile but during vaginal birth the neonate comes into contact with bacteria from the maternal vaginal and intestinal microbiota. The main focus of this doctoral thesis was to elucidate the initial bacterial ecosystem in newborns and to relate microbial perturbations to physiological traits. The bacterial flora was mainly studied with molecu
Background: Despite the fact that old people´s technological needs have been payed much attention to in the last decennium, especially old users of information- and communication technology, technology has not found its natural place in research on ageing in modern societies. Purpose: This article examines to what extent social science research exist in the field of ageing and technology and where
