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Huntington’s disease is caused by a mutation in the gene that codes for the protein huntingtin (HTT). A therapeutic strategy for Huntington’s disease is to lower the levels of huntingtin in the brain. However, multiple clinical trials have been stopped due to adverse effects. This indicates that there is still a lot that we do not understand about huntingtin. Similarly to other neurodegenerative d

The Petit Larousse illustré is a French dictionary first published in 1905. Its division in two main parts on language and on history and geography corresponds to a major milestone in French lexicography as well as a repository of general knowledge from this period. Although the value of many entries from 1905 remains intact, some descriptions now have a dimension that is more historical than cont

Context. The Gaia-ESO Survey (GES) is a large public spectroscopic survey that was carried out using the multi-object FLAMES spectrograph at the Very Large Telescope. The survey provides accurate radial velocities, stellar parameters, and elemental abundances for ~115 000 stars in all Milky Way components. Aims. In this paper, we describe the method adopted in the final data release to derive lith

In this article, I challenge the increasing emphasis on digital technologies to enhance encounters with the past in heritage landscapes. Beginning with a memory from my childhood, I conceptualise presence as being there and review recent approaches in heritage studies that highlight the wide range of benefits derived from embodied experiences in heritage places including reinforcing feelings of we

Background: Parkinson's disease (PD) is a progressive neurodegenerative disorder associated with substantial costs which increase with progression state. However, few studies have investigated the association between costs and health related quality of life. Objectives: To estimate the relationship between costs and health related quality of life, measured by the Parkinson's disease Quality of Lif

We report the discovery of a new ultra-short-period planet and summarize the properties of all such planets for which the mass and radius have been measured. The new planet, K2-131b, was discovered in K2 Campaign 10. It has a radius of and orbits a G dwarf with a period of 8.9 hr. Radial velocities obtained with Magellan/PFS and TNG/HARPS-N show evidence for stellar activity along with orbital mot

Farms can harbor substantial biodiversity, which in turn sustains the supply of ecosystem services. The effectiveness of farm management to enhance biodiversity, however, may be modified by land cover in the surrounding landscape beyond a farmer’s direct control. We examined how landscape pattern and farm management affect the abundance and diversity of native bees visiting highbush blueberry in V

In this work we investigate the decay of the |2p53sP03) state in neon-like ions along the isoelectronic sequence ranging from Z=10 to Z=35. In the absence of a nuclear spin, the magnetic dipole transition to |2p53sP13) is the dominating decay channel. However, for isotopes with a nuclear spin, the interaction between the nuclear magnetic dipole moment and the electronic field introduces a mixing o

We manipulate the information subjects can share on the web concerning socially sensitive actions (public good contribution) and visibility (selfie) to determine the effect on social image, as captured by the price subjects demand for publication. The overall conclusion from the experiment is that theory about social reputation can predict subjects' social-signaling behavior. People take costly de

This article is an in-depth comparative case study of six leadingmanufacturing firms in the Great Zurich region of Switzerland and the Sichuanprovince of China. It employs innovation system approach, institutionalthickness framework and social network analysis to investigate the regionalinstitutions of the two regions and their impact on the connectedness of the casefirms’ internal and external in

The commentary addresses the scope for synergy between climate change policy and social policy in the European Union (EU) from a ‘sustainable welfare’ perspective. The emerging sustainable welfare approach is oriented to the satisfaction of human needs within ecological limits, in an intergenerational and global perspective. While the overall goals of EU climate policy and EU welfare policies larg

Background: The relationship between severe mental illness, poverty and social isolation has been explored in a number of studies. Aim: The purpose of the study was to explore the relationship between financial strain and social isolation. Methods: Sixteen persons with severe mental illness were interviewed about their experience of having a severe mental illness, living in poverty and the effect

Blind people may detect objects from the information in reflected sounds, echolocation. Detection as a function of the number of clicks compared to a continuous noise was tested by presenting clicks of 5 ms with rates from 1 to 64 clicks during a 500 ms period and a 500-ms continuous white noise. The sounds were recorded in an ordinary room through an artificial binaural head. The reflecting objec

The present study focuses on a manager’s understanding of leadership and how this guides – or does not guide practice. The paper reports an empirical in-depth study of a middle manager in an international manufacturing company. We link our discussion to both – the mainstream leadership studies, which assume that managers have a solid type of leadership behavior, and authors with a meaning-oriented

Purpose – In the last decade, greater attention has been paid to the role of management accounting and control (MAC) in making professional organizations more horizontal. The authors argue that earlier research has not shown how the interrelatedness between professional identities and MAC influences attempts to make organizations more horizontal. In this paper the authors respond to the call for m

Objectives: This study aims to describe the prevalence of emotional, physical, and sexual abuse and analyze associations with symptoms of depression and posttraumatic stress (PTS) in pregnancy, by ethnic background. Study design: This is a cross-sectional study of the Swedish data from the Bidens cohort study. Ethnicity was categorized as native and non-native Swedish-speakers. Women completed a q