Filetype
In human cancers, miRNAs are important regulators of multiple cellular processes, and aberrant miRNA expression has been observed, and their alterations contribute to multiple cancer development and progression. Till now, little has been known about the role of miR-204 in human glioblastoma (GBM). In the present study, we used in-vitro assays to investigate the mechanisms of miR-204 in GBM cell li
Objectives To estimate the prevalence and cumulative incidence of gout in southern Sweden with respect to socioeconomic status. Methods Among residents of Skåne region in the year 2013 (total population 1.3 million), adult persons (age 18 years +) who between 1998 and 2013 received a diagnosis of gout (International Classification of Disease 10th Edition (ICD-10) code M10) by any physician were id
The urokinase-type plasminogen activator receptor (uPAR) is a non-integrin vitronectin (VN) cell adhesion receptor linked to the plasma membrane by a glycolipid anchor. Through structure-function analyses of uPAR, VN and integrins, we document that uPAR-mediated cell adhesion to VN triggers a novel type of integrin signalling that is independent of integrin-matrix engagement. The signalling is ful
This paper investigates the relation between organizational change and enacted or experienced workplace bullying. We find that there is a longitudinal relation between organizational change and bullying behaviour and that this effect varies depending on the type of preceding organizational change (task-related or relational change). Task-related change predicts experienced bullying behaviours and
There is a large consensus that higher education institutions exert notable effects on their regional environment. So far, however, much of the related evidence is based on case studies. Few findings are available on a more generalizable level. To bridge this gap, our study uses spatial panel-data models to identify the impacts of higher education institution (HEI) activities on GDP per capita and
Diabetic kidney disease is one of the major complications associated with diabetes. Approximately 25-40% of both type 1 and type 2 diabetes patients will acquire a kidney complication and despite global efforts to reduce the prevalence of diabetic kidney disease, it is a leading cause of kidney failure in the western world. There are few treatment options directly targeting the kidney.The overall
Deoxyribonucleoside kinases (dNKs) salvage deoxyribonucleosides (dNs) and catalyze the rate limiting step of this salvage pathway by converting dNs into corresponding monophosphate forms. These enzymes serve as an excellent model to study duplicated genes and their evolutionary history. So far, among vertebrates only four mammalian dNKs have been studied for their substrate specificity and kinetic
The aim of this thesis was to examine the effect of sleep on emotional memories. The first two studies examined the role of sleep in the generalization of fear learning and the third study examined how sleep affected the forgetting of unwanted emotional memories.In study 1, participants first underwent fear conditioning with a small and a large circle as the CS+ and the CS-. Next, after either a n
Chinese private schools may come across as a contradictory phenomenon: why would an authoritarian and officially socialist government, that needs to rely on education as an instrument of national unification and ideological control, allow for private schools and profit-making in the educational sector? However, seen against the background of the far-reaching privatisation processes that have been
We report here genome sequences and comparative analyses of three closely related parasitoid wasps: Nasonia vitripennis, N. giraulti, and N. tongicomis. Parasitoids are important regulators of arthropod populations, including major agricultural pests and disease vectors, and Nasonia is an emerging genetic model, particularly for evolutionary and developmental genetics. Key findings include the ide
Socio-economic inequalities are remarkable in contemporary developed countries and continue to grow. The sources of these phenomena are not understood, and there is no agreement as to when in an individual’s life they originate, from early childhood to adulthood. The literature showing that health in infancy may be an important factor in later-life health and income trajectories is expanding, but
In this paper, we have investigated, by means of quantitative and statistical methods, stability and change in cultural vocabulary of Indo-European in Europe, with a focus on agriculture. For this purpose we have created a culture vocabulary list with lexical head words, organized into subcategories based on their role and function in a cultural system, the purpose of which is to give a representa
COSMO-RS (conductor-like screening model for real solvents) and three different group-contribution methods were used to compute saturation (subcooled) liquid vapor pressures for 16 possible products of ozone-initiated α-pinene autoxidation, with elemental compositions C10H16O4-10 and C20H30O10-12. The saturation vapor pressures predicted by the different methods varied widely. COSMO-RS predicted r
Psykisk ohälsa är en vanlig bakgrund till att patienter söker hjälp i primärvården men det är inte alltid dessa problem upptäcks. Patienterna erbjuds inte heller alltid adekvat behandling. Det finns flera väl beprövade bedömningsinstrument och evidensbaserade behandlingar för psykisk ohälsa men tillgängligheten till dessa är begränsad i primärvården. I avhandlingen ingår tre delstudier som är utfThe present thesis comprises three studies carried out within REGASSA, a multicenter randomized controlled trial in primary care. In the REGASSA study a 12 week treatment of mild to moderate depression and stress-related mental Health problems using Internet-based cognitive behavioural therapy (ICBT) and physical exercise (PE) was compared with treatment as usual (TAU). The inclusion criteria were
The Mesozoic biotas of Scandinavia have been studied for nearly two centuries. However, the last 15 years have witnessed an explosive advance in research, most notably on the richly fossiliferous Triassic (Olenekian-Carnian) and Jurassic (Tithonian) Lagerstätten of the Norwegian Arctic Svalbard archipelago, Late Cretaceous (Campanian) Kristianstad Basin and Vomb Trough of Skåne in southern Sweden,
The effect of doping and diameter on the electrical properties of vapor-liquid-solid grown GaSb nanowires was characterized using long channel back-gated lateral transistors and top-gated devices. The measurements showed that increasing the doping concentration significantly increases the conductivity while reducing the control over the channel potential and shifting the threshold voltage, as expe
This paper investigates the effects of multinationality on firm productivity, and contributes to the literature in two respects. First, we argue that multinationality affects productivity both directly and indirectly through higher incentives to invest in R&D. Second, we maintain that the multinational depth and breadth have different direct effects on productivity and R&D. Using data from
This article examines the contours of how sex-selective abortion (SSA) and ‘gendercide’ have been problematically combined within contemporary debates on abortion in Europe. Analysing the development of policies on the topic, we identify three ‘turns’ which have become integral to the biopolitics of SSA in Europe: the biomedical turn, the ‘gendercide’ turn, and the Asian demographic turn. Recent a
We study common features in the income velocity of money, income, and interest rates for Canada, the U.S., the U.K., Sweden and Norway using annual data from 1870. The recently developed and refined techniques of testing for cointegration are employed.The evidence suggests there is a unique long-run relationship in velocity but not in income and interest rates. Moreover, we find that only a model
