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Deficiencies of the early complement components of the classical pathway (CP) are well-documented in association with systemic lupus erythematosus (SLE) or SLE-like syndromes and severe pyogenic infections. Among these, complete C1s deficiency has been reported in nine cases so far. Here, we describe a 34-year-old male patient who presented with severe, recurrent infections since childhood, includ

A recent genome-wide association study revealed a variant (rs2431697) in an intergenic region, between the pituitary tumor-transforming 1 (PTTG1) and microRNA (miR-146a) genes, associated with systemic lupus erythematosus (SLE) susceptibility. Here, we analyzed with a case-control design this variant and other candidate polymorphisms in this region together with expression analysis in order to cla

In the paper we present a research model for evaluating determinants of ERP value in small and medium-size enterprises (SMEs). The model is grounded in the diffusion of innovation (DOI) model and resource-based view of the firm (RBV) theory. The research model links six DOI determinants to explain ‘ERP use’ linked with two additional determinants to explain ‘ERP value’, on which nine hypotheses ar

Nyhetsbrev december -24 | Saco-S Linnéuniversitetet Hoppa till huvudinnehåll Öppna sökruta Öppna Huvudmeny Sök på saco.se Om oss Kontakt Lön Arbetstid Lagar & avtal Aktuellt Nyhetsbrev april 2026 Nyhetsbrev december -25 Nyhetsbrev november -25 Saco-S årsmöte 7 oktober 2025 Nyhetsbrev juni -25 Nyhetsbrev december -24 Nyhetsbrev november -24 Saco-S årsmöte 2 oktober 2024 Nyhetsbrev juni -24 Nyhetsbr

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We performed transient absorption (TA) measurements on CP29 minor light-harvesting complexes that were reconstituted in vitro with either violaxanthin (Vio) or zeaxanthin (Zea) and demonstrate that the Zea-bound CP29 complexes exhibit charge-transfer (CT) quenching that has been correlated with the energy-dependent quenching (qE) in higher plants. Simulations of the difference TA kinetics reveal t

Malaria-induced sepsis is associated with an intense proinflammatory cytokinemia for which the underlying mechanisms are poorly understood. It has been demonstrated that experimental infection of humans with Plasmodium falciparum primes Toll-like receptor (TLR)-mediated proinflammatory responses. Nevertheless, the relevance of this phenomenon during natural infection and, more importantly, the mec

There is a class of oligodendrocyte progenitors, called O-2A progenitors, that is characterized by expression of platelet-derived growth factor &agr;-receptors (PDGFR(&agr;)). It is not known whether all oligodendrocytes are derived from these PDGFRalpha-progenitors or whether a subset(s) of oligodendrocytes develops from a different, PDGFR alpha-negative lineage(s). We investigated the re

A computer aided action research method for design of work places is presented. A project group of researchers, managers, union representatives, supervisors, shop-floor workers and representatives from the health-and-safety department analyse different aspects of the physical and organizational work environment. Factory layouts and the flow of raw materials and goods, truck routes and overhead cra

Streptococcus pneumoniae is a leading cause of invasive bacterial infections, with nasal colonization an important first step for disease. While cigarette smoking is a strong risk factor for invasive pneumococcal disease, underlying mechanisms remain unknown. This is partly due to a lack of clinically relevant animal models investigating nasal pneumococcal colonization in the context of cigarette

Pseudomyogenic haemangioendothelioma (PHE) is an intermediate malignant vascular soft tissue tumour primarily affecting children and young adults. The molecular basis of this neoplasm is unknown. We here used chromosome banding analysis, fluorescence in situ hybridization (FISH), mRNA sequencing, RT-PCR and quantitative real-time PCR on a series of morphologically well-characterized PHEs to show t

We hypothesized that the plasmid of urogenital isolates of Chlamydia trachomatis would modulate infectivity and virulence in a mouse model. To test this hypothesis, we infected female mice in the respiratory or urogenital tract with graded doses of a human urogenital isolate of C.trachomatis, serovar F, possessing the cognate plasmid. For comparison, we inoculated mice with a plasmid-free serovar

We report on the development of planar laser-induced fluorescence (PLIF) for CH imaging with improved detection sensitivity for single-shot investigations of turbulent, lean, premixed flames. A ringcavity, pulsed Alexandrite laser was frequency-doubled to excite the lines in the R-branch band-head of the B-X (0,0) band and broadband fluorescence from the B-X (0,1), A-X (1,1) and (0,0) bands, overl

This paper valuates two different financial contracts, the European Call and the Spread option using the Fourier transform. In the European Call case the underlying asset is modelled by the geometric Brownian motion stochastic differential equation. All necessary conditions in order for the transform to exists are examined and it turns out that the payoff needs to be scaled by an exponential facto