Filetype
Cancer presently represents a significant global health challenge, illustrated by the high incidence and mortality rates associated with lung and breast cancer. Technological advances and concerted large-scale initiatives have yielded vast amounts of cancer data to be used for research purposes. The objective of this thesis is to capitalize on the current state of the bioinformatics field to devel
Tumour-induced osteomalacia is caused by tumorous production of fibroblast growth factor 23 (FGF23) leading to urinary phosphate wasting, hypophosphataemia and decreased vitamin D activation. The resulting osteomalacia presents with muscle weakness and bone pain but progresses to multiple pathological fractures. Patients often remain undiagnosed for years with severe physical, psychological and ec
Protein aggregation is a key process in the development of many neurodegenerative disorders, including dementias such as Alzheimer's disease. Significant progress has been made in understanding the molecular mechanisms of aggregate formation in pure buffer systems, much of which was enabled by the development of integrated rate laws that allowed for mechanistic analysis of aggregation kinetics. Ho
Recent studies have explored the influence of obesity and critical illness on ciprofloxacin pharmacokinetics. However, variation across the subpopulation of individuals with obesity admitted to the intensive care unit (ICU) with varying renal function remains unexamined. This study aims to characterize ciprofloxacin pharmacokinetics in ICU patients with obesity and provide dose recommendations for
Objective: To translate and cross-culturally adapt the Stroke Self-Efficacy Questionnaire (SSEQ) from English to Swedish and to evaluate psychometric properties of the questionnaire. Methods: A cross-sectional study design, where the translation followed a process including initial translation, synthesis, backward translation, expert committee, and pretest. Content validity was assessed using Cont
Digitalization and emergence of new technologies including Artificial Intelligence has shaped new organizational principles for the functioning of economies and societies globally. Technology has also changed the landscape for taxation and interactions between tax administration and taxpayers. Recently various models of electronic reporting and invoicing, split-payment mechanisms as well electroni
Taking point of departure in two black dolls that once belonged to Sophie Christine Oxholm and to the family of Clara Asenath Schultz, the article explores aspects of childhood and childcare in colonial homes. Both girls grew up in the Danish West Indies in the nineteenth century and were cared for by African Caribbean nannies – the likely makers of the dolls. Drawing on historical and literary so
This article examines limits to per capita living space (i.e. living smaller and/or sharing living space) as a measure for achieving sufficiency in housing. It studies the acceptance, motivation and side-effects of voluntarily reducing living space in five European Union countries: Germany, Hungary, Latvia, Spain and Sweden. Insights are derived from an extensive collection of qualitative empirica
Vascular aging is described as a gradual process involving biochemical, enzymatic, and cellular changes of the vasculature and modification of the signals that modulate them. On the basis of this conception a new pathophysiological model for deeper understanding of cardiovascular risk and its treatment was introduced. The idea of early vascular aging, that is the acceleration of vascular aging see
Popular Abstract in Swedish Sedan människan lyckades skapa eld har förbränning utgjort den viktigaste energikällan i mänsklighetens långa historia, viket den ser ut att fortsätta vara det inom en överskådlig framtid. I dagsläget kommer mer än 90% av vår energi från förbränningsprocesser. Dock uppstår en rad problem kring förbränning, såsom föroreningar och möjligheten till använda sig av förnyelseNowadays, more than 90% of our energy comes from combustion processes. Hence, it is very important to perform combustion research to reduce emissions, improve efficiency, find clean and renewable fuels, strengthen safety, etc. The complexity of combustion processes asks for advanced diagnostic tools, among which the laser spectroscopy has been proved to be a powerful one. This thesis is about the
The antigens of the ABO system were the first to be recognized as blood groups and actually the first human genetic markers known. Their presence and the realization of naturally occurring antibodies to those antigens lacking from the cells made sense of the erratic failure of blood transfusion hitherto and opened up the possibility of a safe treatment practice in life-threatening blood loss. Alth
