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MHC genes are extraordinarily polymorphic in most taxa. Host-pathogen coevolution driven by negative frequency-dependent selection (NFDS) is one of the main hypotheses for the maintenance of such immunogenetic variation. Here, we test a critical but rarely tested assumption of this hypothesis—that MHC alleles affect resistance/susceptibility to a pathogen in a strain-specific way, that is, there i

Introduction: In Sweden, head computed tomography (CT) is commonly used for prediction of neurological outcome after cardiac arrest, as recommended by guidelines. We compare the prognostic ability and interrater variability of routine and novel CT methods for prediction of poor outcome. Methods: Retrospective study including patients from Swedish sites within the Target Temperature Management afte

Granitic rocks are durable materials sought after for the production of road and railroad aggregates. Granitic bedrock commonly, however, includes gabbroic components, which may enhance or decrease the aggregate performance. This study evaluates the variation in resistance to fragmentation (Los Angeles value, LA) and wear/abrasion (micro-Deval value, MDE) for the fraction 10/14 mm of gabbro in dif

This chapter analyzes the epistemological hierarchy around the middleof the nineteenth century in Sweden through efforts to mobilize supportfor natural science in scholarly periodicals. It is argued that scholarlycommunication was key to achieving legitimacy for natural science, butthat such efforts were mitigated by a dominant view of the humanitiesin general and classical humanism in particular

Electroelastic materials possess properties most attractive for the design of smart devices and systems such as actuators and sensors. Typical polymers show changes in shape under the action of an electric field, and vice versa, together with fast actuation times, high strain levels and low elastic moduli. This paper deals with an Ogden model inspired framework for large deformation electroelastic

The presence of viral immune triggers at the intestinal mucosa can have multipleglobal effects on intestinal integrity, including relative protection fromsubsequent inflammatory bowel disease. During the last century, the westernworld has achieved a remarkable success in preventing infectious diseases,which increased the general life expectancy dramatically. However, theincidence and prevalence of

This article addresses how urban Destination Management Organisations (DMOs) in Sweden, have understood their communicative role, developed communicative strategies and tactics in relation to stakeholders during the COVID-19 pandemic. The aim of this research is to explore communication strategies for urban destination resilience. DMOs have a key role in balancing the interest of stakeholders, the

The complement system is a proteolytic cascade triggered by pathogen and danger-associated molecular patterns, with resultant outcomes of inflammation, cellular activation, and opsonization of material for removal by phagocytosis. While first discovered as an activity in serum, it is now recognized that complement components play important roles at local and individual cell-intrinsic levels. In pa

Cardioneuroablation has emerged as a potential alternative to cardiac pacing in selected cases with vasovagal reflex syncope, extrinsic vagally induced sinus bradycardia-arrest or atrioventricular block. The technique was first introduced decades ago, and its use has risen over the past decade. However, as with any intervention, proper patient selection and technique are a prerequisite for a safe

This chapter presents an interpretation of Bernard Williams’s significant and substantial contributions on the topic of free will and moral responsibility. Williams’s fundamental objective, it is argued, is to vindicate moral responsibility by way of freeing it from distortions and misrepresentations imposed on it by “the morality system.” Although his earlier work is primarily concerned with the

In this research–in–progress paper, we employ design science research to articulate design knowledge for chatbots in higher education practice. We conducted a literature review to factor previous research into the design process. In addition, we performed a content analysis of student e-mails and forum posts from four instances of a basic Java programming course. Drawing from literature and data,

Oath-taking during Roman Antiquity constitutes a telling example of how words and matter interplay and relate to one another. Ancient Latin literature provides a myriad of representations of oaths sworn, both fictive and supposedly historical, where matter somehow figure in the procedure. In this study, a selection of personal oaths from Roman literature are explored in terms of materiality and ag

The present study collected a wide range of experimental data samples, including 855 records from various types of cylindrical weirs under diverse hydraulic conditions, setting the stage for an in-depth analysis for modeling of discharge coefficient. For this purpose, the prediction capability of four kernel-based methods (SVM, GPR, KELM, and KRR) and four neural network-based methods (FFBP, CFBP,

Remembering Classical Scandinavia in Britain, 1760–1830 explores the use of Scandinavian themes in British culture in the decades around 1800. It offers new paradigms for how cultural texts engage with the classical Scandinavian past, historiographically and thematically. The classical Scandinavian past was the subject of intense interest during the period but often also coupled with a sense that

Background: Light microscopy and rapid diagnostic tests (RDT) have long been the recommended diagnostic methods for malaria. However, in recent years, loop-mediated isothermal amplification (LAMP) techniques have been shown to offer superior performance, in particular concerning low-grade parasitaemia, by delivering higher sensitivity and specificity with low laboratory capacity requirements in li