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PURPOSE: This study was designed to characterize rectal sensations by visualizing the internal and external anal sphincter and intra-anal transport of bolus during elicited rectal sensations. METHODS: The anal canal was visualized with real-time transperineal ultrasonography in 13 healthy female volunteers. Rectal sensations were elicited by injecting water into the rectum. The ultrasound images w

Glucose-evoked insulin secretion exhibits a biphasic time course and is associated with accelerated intracellular granule movement. We combined live confocal imaging of EGFP-labelled insulin granules with capacitance measurements of exocytosis in clonal INS-1 cells to explore the relation between distinct random and directed modes of insulin granule movement, as well as exocytotic capacity. Reduci

We report the first experimental measurements and theoretical calculations for the hyperfine splitting of the 3d(5) 4s ground state of Mn II. The hyperfine structure constants were determined using Fourier transform spectroscopy with a hollow cathode discharge lamp. The uncertainties in the magnetic dipole constants, A, are between 3 x 10(-4) and 5 x 10(-4) cm(-1). Extensive configuration interact

Immunization of mice with type II collagen (CII), a cartilage-restricted protein, leads to collagen-induced arthritis (CIA), a model for rheumatoid arthritis (RA). CIA symptoms consist of an erosive joint inflammation caused by an autoimmune attack, mediated by both T and B lymphocytes. CD4+ alphabeta T cells play a central role in CIA, both by helping B cells to produce anti-CII antibodies, and b

Maturation of dendritic cells (DC) serves a deterministic role in the link between innate and adaptive immunity, constituting a checkpoint with regard to whether responses from the lymphocyte compartment shall be raised and what class of response is needed to protect the host against invading pathogens. Since DC have not been shown to possess mechanisms such as gene recombination or somatic mutati

We used a series of CO⁵BOLD hydrodynamical model atmospheres covering stellar objects from white dwarfs to red giants to derive theoretical estimates of the photometric and photocentric stellar variability in wavelength-integrated light across the Hertzsprung-Russell diagram. We validated our models against solar measurements from the SoHO/VIRGO instrument. Within our set of models we f

In this paper we argue that Long Wave Theory provides a useful conceptual tool for understanding the transition from the industrial to the, post-industrial economy. While economic theories struggle to fully explain the structural changes involved in the shift towards the information economy, long wave theory offers a promising avenue for understanding the complex relationship between technology an

Anti-GBM disease is a rare autoimmune condition characterized by autoantibodies targeting the alpha 3 chain non-collagen 1 domain of type IV collagen (alpha 3(IV)NC1). Recently, we isolated IgG reacting with alpha 3(IV)NC1 from normal healthy human sera. The current study examined the antigen and epitope specificity of these natural autoantibodies (NAA) using recombinant human alpha 1, 3, 5(IV)NC1

Absorption and fluorescence spectra of 2-R-5-phenyl-1,3,4-oxadiazoles (R = H, methyl, tert-butyl, trifluoromethyl, amino, phenyl, benzyl) were studied experimentally and by time dependent density functional theory (TDDFT) methods. In acidic media a substantial red shift is observed due to the presence of conjugate acid forms. Two conjugate acid forms (3H and 4H) are possible for unsymmetrically su

A novel surface protein of the bacterial species Moraxella catarrhalis that displays a high affinity for IgD (MID) was solubilized in Empigen and isolated by ion exchange chromatography and gel filtration. The apparent molecular mass of monomeric MID was estimated to approximately 200 kDa by SDS-PAGE. The mid gene was cloned and expressed in Escherichia coli. The complete mid nucleotide gene seque

From January 1, 1983, through December 31, 1992, a total of 4610 patients entered a randomized trial that compared mortality among patients receiving 2 years of adjuvant tamoxifen therapy with that in patients receiving 5 years of adjuvant tamoxifen therapy, 4175 of whom were recurrence free after 2 years of tamoxifen therapy. Among the 2046 patients randomly assigned to the 5-year group all-cause

Several monouranium and diuranium polyhydride molecules were investigated using quantum chemical methods. The infrared spectra of uranium and hydrogen reaction products in condensed neon and pure hydrogen were measured and compared with previous argon matrix frequencies. The calculated molecular structures and vibrational frequencies were used to identify the species present in the matrix. Major n

The majority of microarray studies focus on analysis of gene expression differences between various specimens or conditions. However, the causes of this variability from one cancer to another, from one sample to another and from one gene to another often remain unknown. In this study, we present a systematic procedure for finding genes whose expression levels are altered due to an intrinsic or ext

The immunodominant T-cell epitope that is involved in collagen-induced arthritis (CIA) is the glycosylated type II collagen (CII) peptide 256-270. In CII transgenic mice, which express the immunodominant CII 256-270 epitope in cartilage, the CII-specific T cells are characterized by a partially tolerant state with low proliferative activity in vitro, but with maintained effector functions, such as

Popular Abstract in Swedish Kroppen som socialt fenomen har inte varite ett dcentralt tema inom sociologin. Detta försöker Lars-Erik Alkvist komma till rätta med, på grundval av en omläsning av Max Webers sociologi utifrån temat kroppens sociologi. Författaren menar att det hos Weber finns en dold med dock närvarande förståelse av kroppens sociala sammanhang. Men Webers förståelse av kroppen sitteThis thesis is about the social body in sociology, represented by the classical sociologist Max Weber. Traditional sociology has not taken the body into account. The body has been considered to belong to the realm of the natural sciences. Sociology has seen the body merely as an instrument or a tool for social action. The mind/body dichotomy, homo duplex, prevails in sociology. The purpose of this

Background: Infection with group B streptococci (GBS) is a serious neonatal disease. The GBS cell surface proteins a and Rib elicit protective immunity in animal models and have been suggested as potential antigens in a vaccine against human GBS disease. Aims: To test the hypothesis that transplacentally transferred maternal antibodies to GBS proteins contribute to the protection of the neonate fr