Filetype
BACKGROUND: The purpose of this study was to estimate precise age-specific tubo-ovarian carcinoma (TOC) and breast cancer (BC) risks for carriers of pathogenic variants in RAD51C and RAD51D. METHODS: We analyzed data from 6178 families, 125 with pathogenic variants in RAD51C, and 6690 families, 60 with pathogenic variants in RAD51D. TOC and BC relative and cumulative risks were estimated using com
A 67-year-old, previously fit, woman presented with a history of rectal bleeding.Per rectum examination revealed alow rectal mass, which on endoscopy wasdemonstrated to be submucosal. MR rectumconfirmed a 5 cm rectal mass displacing therectum anteriorly. Chest x-ray and abdominalCT did not reveal any metastatic disease. Biopsies were consistent with high grade gastrointestinal stromal cell tumour
Vocal tract elongation, which uniformly lowers vocal tract resonances (formant frequencies) in animal vocalizations, has evolved independently in several vertebrate groups as a means for vocalizers to exaggerate their apparent body size. Here, we propose that smaller speech-like articulatory movements that alter only individual formants can serve a similar yet less energetically costly size-exagge
Stars ejected from the Galactic Center can be used to place important constraints on the Milky Way potential. We have used Hills stars to constrain models for the Galactic potential, demonstrating that meaningful constraint can be obtained if we have samples of around 50 nearby Hills stars.
This chapter focuses on the personal experiences of collaborations based on academic–practitioner interactions, which are not always as straightforward as presented in commonplace transdisciplinary theory. By using autoethnographic methodology, this chapter provides some of the most important insights from past and ongoing work from a major sustainability project that uses the ‘Research Forum’ (RF
The article analyses recent public initiatives to memorialise the establishment of India and Pakistan as postcolonial states in terms of violent partitioning rather than as a successful act of independence from British imperialism. The twin focal points of the article are the Partition Museum in Amritsar and the online 1947 Partition Archive. Both of these subscribe to and further the view that di
Background and purpose — Despite the good results after total hip arthroplasty (THA), new implants are continuously being developed to improve durability. The Echo Bi-Metric (EBM) THA stem is the successor to the Bi-Metric (BM) THA stem. The EBM stem includes many of the features of the BM stem, but minor changes in the design might improve the clinical performance. We compared the migration behav
With the broader industrial application of Additive Manufacturing (AM), designers are facing new challenges in conceptual design for AM. To better understand the problematic, the authors organised a design workshop with six experts in AM. The paper presents the results of the conducted design workshop and discusses the current and future trends in research on the conceptual design for AM.
Background and purpose — Fast-track care programs have been broadly introduced at Swedish hospitals in elective total hip and knee replacement (THR/TKR). We studied the influence of fast-track programs on patient-reported outcomes (PROs) 1 year after surgery, by exploring outcome measures registered in the Swedish arthroplasty registers. Patients and methods — Data were obtained from the Swedish K
The Georgian Orthodox Church (GOC) organisation has 15 departments, which focus on a wide range of areas from missionary work to finance, economy, real estate, ecology and military. This chapter focuses on historical and political contexts that shaped the GOC as an organisation over time. The GOC’s organisation is headed by Patriarch Ilia, while the administrative–operational part is conducted by
The intestinal surface is daily challenged with tremendous amount of foreign material derived our diet and from the commensal bacteria that densely populate the mucosal surface. Occasionally the gut mucosa is exposed to pathogens trying to enter our body. The important task of the intestinal immune system is to remain tolerant toward innocuous luminal constituents and to elicit defense responses t
Supermassive black holes are found in most galactic nuclei. A large fraction of these nuclei also contain a nuclear stellar cluster surrounding the black hole. Here we consider the idea that the nuclear stellar cluster formed first and that the supermassive black hole grew later. In particular we consider the merger of three stellar clusters to form a nuclear stellar cluster, where some of these c
After a brief discussion on the varying nomenclature applied to the field, this article discusses the two basic orientations: academic and applied. From there, the discussion takes up the sprawling character of the field, underscoring that the field can be conceptually organized in a variety of ways. The main part of the discussion consists of a presentation of four major schools of thought. These
Precipitation is often the most important input data in hydrological models when simulating streamflow. The Soil and Water Assessment Tool (SWAT), a widely used hydrological model, only makes use of data from one precipitation gauge station that is nearest to the centroid of each subbasin, which is eventually corrected using the elevation band method. This leads in general to inaccurate representa
This study provides a comprehensive evaluation of eight high spatial resolution gridded precipitation products in Adige Basin located in Italy within 45–47.1°N. The Adige Basin is characterized by a complex topography, and independent ground data are available from a network of 101 rain gauges during 2000–2010. The eight products include the Version 7 TRMM (Tropical Rainfall Measuring Mission) Mul
