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Multi-scale plasticity modeling: coupled discrete dislocation and continuum crystal plasticity

A hierarchical multi-scale model that couples a region of material described by discrete dislocation plasticity to a surrounding region described by conventional crystal plasticity is presented. The coupled model is aimed at capturing non-classical plasticity effects such as the long-range stresses associated with a density of geometrically necessary dislocations and source limited plasticity, whi

Diffusion of the Balanced Scorecard in the Swedish Municipality Sector

This article examines the introduction of the Balanced Scorecard (BSC) among municipalities in Sweden from a diffusion perspective. The point of departure in the article is that there is a gap in our understanding concerning the diffusion of new management accounting constructs. Over the last decade, research has largely been based on empirical evidence regarding early adopters. Furthermore, these

Software Configuration Management Issues with Industrial Opensourcing

The industrial involvement in Open Source Software projects is increasing. More and more companies are turning their proprietary code into open source, contribute actively to the development of Open Source Software projects or/and use Open Source Software products as (part of) their own products. Software Configuration Management provides the infrastructure that is the foundation for any type of s

A glioma classification scheme based on coexpression modules of EGFR and PDGFRA

We hypothesized that key signaling pathways of glioma genesis might enable the molecular classification of gliomas. Gene coexpression modules around epidermal growth factor receptor (EGFR) (EM, 29 genes) or platelet derived growth factor receptor A (PDGFRA) (PM, 40 genes) in gliomas were identified. Based on EM and PM expression signatures, nonnegative matrix factorization reproducibly clustered 1

The physical state of water in bacterial spores.

The bacterial spore, the hardiest known life form, can survive in a metabolically dormant state for many years and can withstand high temperatures, radiation, and toxic chemicals. The molecular basis of spore dormancy and resistance is not understood, but the physical state of water in the different spore compartments is thought to play a key role. To characterize this water in situ, we recorded t

Decomplexing biofluids using microchip based acoustophoresis

Highly efficient washing and extraction of microbeads to decomplex analytes ranging from small peptides to large viruses was realised in a microscaled continuous flow format. The bead washing principle reported herein is based on acoustophoresis, i.e. the primary acoustic radiation force in an ultrasonic standing wave and laminar flow properties are utilised to translate bioanalytes trapped on fun