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Accumulation of Nodularia spumigena toxins by Mytilus edulis was studied during laboratory and mesocosm experiments in order to investigate the possible pathways of nodularin in mussels and calculate toxin budgets. Mussels were exposed to 0.2-15.6 mu g nodularin 1(-1), fed for up to 5 days with Nodularia cells from culture, or blooming in different nutrient-treated seawater. Toxin concentration wa
Blood coagulation factors IX and X are two serine proteases with a similar modular structure. The non-catalytic part of each protein consists of a gamma-carboxyglutamic acid (Gla)-containing module and two modules homologous to the epidermal growth factor (EGF) precursor. We have now found that the NH2-terminal EGF-like module of both factors IX and X inhibits factor Xa formation in a Gla-independ
The human L3MBTL gene is located in 20q12, a region that is commonly deleted in myeloproliferative disorders (MPD), myelodysplastic syndromes (MDS), and acute myeloid leukemia (AML). L3MBTL is highly homologous to the D-lethal(3) malignant brain tumor [D-l(3)mbt] gene, which is a putative tumor-suppressor gene (TSG) identified in Drosophila and which is closely related to the Drosophila sex combs
The LKB1 tumour suppressor kinase phosphorylates and activates a number of protein kinases belonging to the AMP-activated protein kinase (AMPK) subfamily. We have used a modified tandem affinity purification strategy to identify proteins that interact with AMPKalpha, as well as the twelve AMPK-related kinases that are activated by LKB1. The AMPKbeta and AMPKgamma regulatory subunits were associate
There are quite detailed structural data on the extracellular ligand-binding domain and the intramembrane channel-forming domain of the nicotinic acetylcholine receptors (nAChR). However, the structure of the intracellular domain, which has variable amino acid sequences in different nAChR subunits, remains unknown. We expressed in Escherichia coli the intracellular loops (between transmembrane fra
We developed nine polymorphic microsatellite loci for the field vole, Microtus agrestis. The number of alleles ranged from five to 15 and observed heterozygosities ranged from 0.40 to 1.00. We also tested the microsatellite loci for amplification and polymorphism in the congeneric species Microtus arvalis. Five of the nine loci were successfully analysed in this species. The microsatellite markers
Popular Abstract in Swedish Markören LE i kinesiska är speciell av flera olika skäl. Bland annat kan den uppträda på två ställen i en sats, dels direkt efter ett verb och dels i slutet av en mening. Beroende på var den uppträder kan den ofta - men inte alltid - påverka meningen på olika sätt. Det är en av anledningarna till att språkvetare ofta har valt att se LE som två olika markörer med olika fThe grammatical marker LE in Mandarin Chinese can occur in two syntactic positions, either immediately following the verb or at the end of a sentence. Traditionally, it has been described as two homophonous but syntactically distinct morphemes, verbal LE and sentence-final LE. This view seems to be based on assumptions about (1) the historical origin of LE, (2) the relation between LE and its coun
The severe fouling common in food processing puts high demands on equipment cleaning. Adsorption of the protein betalactoglobulin to solid surfaces and its subsequent removal were followed using in situ ellipsometry. Most experiments were done in a stirred cuvette. Additionally, a flow cell was designed, which was employed in some work. The characteristics of the surface were shown to influence p
This thesis describes novel molecular host-parasite interactions with potential significance for the understanding of pathological processes manifested with bacterial infections. Bacterial surface proteins and virulence determinants are shown to mediate the accumulation at the surface of the pathogen of key components of the fibrinolytic and contact phase systems. Plasmin(ogen) binding surface pr
This Special Issue of the International Journal of Consumer Studies focuses on ‘political and ethical consumerism around the world’. An increasingly debated consumer issue – both in academia and among various stakeholders – is whether, or how, the market can function in new ways as a political arena, and to what extent consumers can use the market to become (sub)politically active. ‘Political and
As scientific collaboration is a phenomenon that is becoming increasingly important, studies on scientific collaboration are numerous. Despite the proliferation of studies on various dimensions of collaboration, there is still a dearth of analyses on the effects, motives and modes of collaboration in the context of developing countries. Adopting Wallerstein's world-system theory, this paper makes
This edited volume examines the continued viability of international human rights law in the context of growing transnational law enforcement. With states increasingly making use of global governance modes, core exercises of public authority such as migration control, surveillance, detention and policing, are increasingly conducted extraterritorially, outsourced to foreign governments or delegated
1. In normal mice, the distribution of adrenergic, cholinergic, some peptidergic, and neuronal nitric oxide synthase (nNOS)-containing nerves were investigated. Functional in vitro correlates were obtained. An in vivo model was developed in which erectile haemodynamics in response to drugs or nerve-stimulation were studied. 2. Immunoreactivities for vesicular acetylcholine transporter protein (VAC
Background: The K3326X variant in BRCA2 (BRCA2∗c.9976A>T p.Lys3326∗rs11571833) has been found to be associated with small increased risks of breast cancer. However, it is not clear to what extent linkage disequilibrium with fully pathogenic mutations might account for this association. There is scant information about the effect of K3326X in other hormonerelated cancers. Methods: Using weighted lo
Background: Knowledge regarding factors that influence deviation of the QRS axis is important when seeking to differentiate between physiological and pathological changes. We hypothesised that, in contrast to those patients with an atrioventricular septal defect and common atrioventricular junction permitting only atrial shunting, those associated with ventricular shunting would show no relationsh
One of the most significant current discussions in Knowledge Sharing (KS) is security. Security is an important component in KS, and plays a key role in reducing the risks in KS. However, relatively little study has been performed on KS security in the public and private sectors, and even less in the developing countries. This research intends to find the relationship between organizational contex
