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Predictive monitoring of turn-on-turn insulation in single tooth coils

This work focuses on the investigation on both local and global dielectric properties for a random wound single tooth winding, which represents a segment of the in-field electrical machine used on an Hybrid Wheel Loader. Finite Element Analysis (FEA) is used to predict the temperature stress while loading and illustrate the influences of dielectric properties (i.e. conductivity and dielectric cons

Particle separation and diffusion based limitation

Deterministic lateral displacement (DLD) is a promising method for particle separation in the micrometer range, the proof of principle of which has been demonstrated to be successful in fields such as biomedicine and physics [1]. However, the enhanced particle dispersion (Figure 1 & 2) arising when separating very small particles (such as viruses and proteins) constitutes the main functional b

Detailed characterization of plasmids carrying resistance genes using optical DNA mapping

We present an assay, based on optical DNA mapping in nanochannels that is capable of characterizing the plasmid content of bacterial isolates resistant to antibiotics in a fast an detailed way. In a single experiment we determine the number of different plasmids in each sample, their size, as well as a barcode that can be used for plasmid identification and tracing. In addition we demonstrate that

Abnormalities in kynurenine pathway metabolism in treatment-resistant depression and suicidality : a systematic review

Treatment resistant depression (TRD) and suicidal behavior are among the most important public health problems and are commonly associated with significant disability and psychosocial impairment. Although there have been recent advances in identifying neurobiological correlates of these complex conditions, their pathophysiology still remains unclear. Although the recent advances concerning the neu

Sexual Harassment in the Workplace in Relation to EC Legislation

The first part of the article is an outline of the nature of sexual harassment, its extent and the growing awareness of it. The second part considers why there was a need for a community initiative and looks at the extent of sexual harassment in the Member States, the consequences of sexual harassment, legal remedies and the impact it has on the community's principles, including health and safety

Is Competitive Elite Sport Really Morally Corrupt?

It has been argued that competitive elite sport both a) reduces the humanity of athletes by turning them into beings whose sole value is determined in relation to others, and b) is motivated by a celebration of the genetically superior and humiliation of the weak. This paper argues that while a) is a morally reproachable attitude to competition, it is not what competitive elite sport revolves arou

Explosion fatalities in Sweden, 2000–2018

Epidemiological aspects of explosion-related deaths in a civilian setting may bring comprehensive knowledge that isimportant for prevention efforts. This Swedish national study aimed to describe the extent of such deaths, circumstancesand fatal injuries. Data, including all explosion-related deaths in Sweden from 2000 through 2018, were retrieved from theregister of the National Board of Forensic

Identifying bacteria using DNA binding maps

We have developed an assay, based on nanofluidic channels and fluorescence microscopy, for optical mapping of DNA based on competitive binding between two molecules - one fluorescent and one sequence selective. From the experimental data we can extract binding constants for the two competing DNA binders, which may be subsequently used to calculate a theoretical reference map of any DNA with known

Tunable separation and DNA manipulation in metal coated pillar arrays

Implementing electrically connected metal-coated posts in a Deterministic Lateral Displacement (DLD) device and applying electric fields, we use electrokinetics to achieve tunable particle separations and to trap and manipulate DNA. The strength of DLD stems from its typically binary behavior. Particles move in one out of two trajectories based on their effective size. For particles that are close

ACouWash : A standalone instrument for the washing, separation and enrichment of cells.

We developed the AcouWash (Figures 1 and 2), a benchtop instrument for flow-through cell and particle separation by acoustophoresis. Building on previous research [1-4] AcouWash can re-suspend cells in new medium, separate cells based on size or acoustic properties, or enrich cells, Figure 3. We present our initial evaluation of AcouWash regarding size-based separation of particles, cell washing,

Evidence that the antibiotic ciprofloxacin counteracts cyclosporine‐dependent suppression of cytokine production

The fluoroquinolone antibiotic ciprofloxacin (cipro) has been reported to upregulate interleukin 2 and interferon-γ production in lectin-stimulated lymphocytes. The aim of this study was to elucidate whether cipro and the immunosuppressive agent CsA have antagonistic action on cytokine synthesis. Accumulation of IL-2 and IFN-γ protein and mRNA were analyzed in polyclonally (PHA or Con A) or alloan