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The stability toward thermal and urea denaturation was measured for HAMLET (human -lactalbumin made lethal to tumor cells) and -lactalbumin, using circular dichroism and fluorescence spectroscopy as well as differential scanning calorimetry. Under all conditions examined, HAMLET appears to have the same or lower stability than -lactalbumin. The largest difference is seen for thermal denaturation o
Mucosal pathogens trigger a local innate host response by activating epithelial cells. Bacterial adherence and Toll-like receptor 4 (TLR4) signaling have been implicated as key events in this process. This study addressed the molecular basis of the epithelial response to gram-negative infection in the human urinary tract. Mucosal biopsies were obtained from kidneys, ureters, and bladders of patien
BackgroundMajor depressive disorder (MDD) is associated with increased allostatic load (AL; a measure of physiological costs of repeated/chronic stress-responding) and metabolic dysregulation (MetD; a measure of metabolic health and precursor to many medical illnesses). Though AL and MetD are associated with poor somatic health outcomes, little is known regarding their relationship with antidepres
One of the great challenges within software testing is to know ira test suite covers a program sufficiently. Mutation analysis is presented as an approach to address that challenge. Faulty versions, or mutants, are created and it is investigated if the test suite is able to discover the defects. The technique is mostly applied to the unit level testing of software programs. In this paper, mutation
Background: Systemic low-grade inflammation may be a pathophysiological mechanism in a subtype of depression. In this study we investigate a novel candidate mechanism of inflammatory depression - Selective Glomerular Hypofiltration Syndromes (SGHS) - which are characterized by a reduced estimated glomerular filtration rate (eGFR) based on cystatin C (cysC) relative to eGFR based on creatinine (cre
Sleep is a universal and complex state and it is widely agreed that this state is present in every animal species. However, the evolutionary origins of sleep remain ignored or misunderstood, which has led researchers to study, in various species, this common behaviour of all living organisms. Sleep is commonly studied at various levels under laboratory conditions, using tethered devices which reco
Electric road systems (ERSs) present a transformative advancement in transportation electrification, offering continuous charging capabilities for electric vehicles (EVs) during travel. This innovation has the potential to significantly mitigate range anxiety by enabling in-motion charging, thereby enhancing the overall efficiency of electric mobility, and reducing the frequency of charging stops
A considerable amount of evidence from several intonation languages (e.g., German, English, Italian) supports the idea that F0 peak timing, height, and shape variables form a feature bundle, which is used to encode two-fold intonational (e.g., sentence-level) pitch accent distinctions such as L+H* vs. L*+H. The three types of features in the bundle can be weighted differently but the outcome seems
Lightweight walls and floors are often designed as frameworks of studs with plates on each side - a double-plate structure. The free wave-modes and periodic wave motion of a double-plate system reinforced by joists are analysed in the present paper (as the insertion loss and impact sound insulation have been studied in previous papers). The free wave-modes can in a future step be used in connectio
GeoBIM, the integration of 3D geoinformation (Geo) with building information models (BIM), is a subject of increasing attention in both domains. A well-known practical challenge for this integration is the mixed state of software support for open standards in each domain that would ease the integration. This is often known by practitioners but poorly documented. In order to solve this problem, we
This article analyzes the artistic exploration of machine vision in the video installation Modern Escape (2018) by Danish artist duo Hanne Nielsen and Birgit Johnsen. The artwork recreates a modern Western home pervaded by surveillance technologies and the automated vision of a robotic vacuum cleaner. The main conceptual idea of the work is the automated gaze, and with few exceptions, all the scen
