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Objective: Inflammation is associated with major depressive disorder (MDD) and suicidal behavior. According to the ‘leaky gut hypothesis’, increased intestinal permeability may contribute to this relationship via bacterial translocation across enterocytes. We measured plasma levels of gut permeability markers, in patients with a recent suicide attempt (rSA), MDD subjects with no history of a suici
The pathogenesis of Parkinson’s disease (PD) involves the accumulation of aggregated -synuclein, which has been suggested to begin in the gastrointestinal tract. Here, we determined the capacity of the appendix to modify PD risk and influence pathogenesis. In two independent epidemiological datasets, involving more than 1.6 million individuals and over 91 million person-years, we observed that rem
We present new BVI photometry containing 40,000 stars of the Galactic globular cluster M15 (NGC 7078) covering a 25×25 arcminute area centered on the cluster with a magnitude range from the tip of the Red Giant Branch to three magnitudes below the main sequence turn-off. Using α -enhanced Dartmouth Stellar Evolution Program models, we find an age of 13.0 ± 1.0 Gyr and distance modulus of (m−M)V=15
The new contacts with the west reaffirmed the idea of interaction between the west and the Arab world. New literary works compared and contrasted the spirituality of the East with the materialism of the West - a theme that became a common one in modern Arabic literature.
BackgroundThe optimal ways of using aromatase inhibitors or tamoxifen as endocrine treatment for early breast cancer remains uncertain.MethodsWe undertook meta-analyses of individual data on 31 920 postmenopausal women with oestrogen-receptor-positive early breast cancer in the randomised trials of 5 years of aromatase inhibitor versus 5 years of tamoxifen; of 5 years of aromatase inhibitor versus
This chapter examines how multinational corporations communicatively navigate moral responsibility during geopolitical crises, focusing on the war in Ukraine. As corporations increasingly are expected to engage with social and political issues, their actions, or inactions, are interpreted as moral stances. We contend that a feminist ethics of care offers a compelling approach through which to unde
