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188Re-ZHER2:V2, a promising affibody-based targeting agent against HER2-expressing tumors : preclinical assessment

UNLABELLED: Affibody molecules are small (7 kDa) nonimmunoglobulin scaffold proteins with favorable tumor-targeting properties. Studies concerning the influence of chelators on biodistribution of (99m)Tc-labeled Affibody molecules demonstrated that the variant with a C-terminal glycyl-glycyl-glycyl-cysteine peptide-based chelator (designated ZHER2:V2) has the best biodistribution profile in vivo a

A possible role of the pancreatic α1- and α2-cells as local regulators of insulin secretion

In addition to a majority of insulin-producing β-cells, the mammalian pancreatic islets contain considerable numbers of α1- and α2-cells. While the α2-cells are the cellular source of glucagon, the secretory product stored in the granules of the α1-cells still remains to be identified.Several authors have reported that glucagon stimulates insulin release. This effect of glucagon was found to be de

Why Pashukanis was right : Abstraction and form in The General Theory of Law and Marxism

The area of Marxism and law has long been considered marginalised. However, hand in hand with the renaissance of Marxist theory in recent decades, neglect has finally been put to rest. As Marxists increasingly explore the connections between rights, law, democracy and capitalism, one text in particular has taken centre stage: The General Theory of Law and Marxism, published by E. B. Pashukanis in

Listening across Borders : Global Considerations for Listening and Public Diplomacy

Listening in public diplomacy is a rather new topic in academic discussions. Early public diplomacy scholarship was dominated, and in large degree continues to be dominated, by a focus on crafting messages and influencing. The more recent focus on relationship management and collaborative public diplomacy allowed for discussions about another role for listening. Yet, as some scholars pointed out,

Luftkvalitet i överbyggda stationsmiljöer

Den pågående expansionen av järnvägstransporter, för både personresor och varutransporter, gör att den rälsbundna trafiken ökar kraftigt. I samband med att personresor och pendling med tåg och järnväg ökar sker också en expansion av antalet mer eller mindre slutna stationsmiljöer under mark. Dessa miljöer kan innebära en hälsorisk genom kombinationen av slutna utrymmen och höga halter av luftburna

Imagetext and ekphrasis as chances of revival in translation studies

Translation Studies has crossed a tumultuous interval of theorization. But has it passed the linguistic limits instituted by a semiotician like Umberto Eco? Wouldn’t be the time to access more courageously the intersemiotic interregnum with its heterogeneous transfer of signs? As it happens in advertising, concrete poetry, tattoos, and stage or filmed version of famous texts? If we have gradually

Medical methods and Patentability of Nanomedicine in Europe: small matter, large interrogations

The present article was presented at the ATRIP Congress 2015. The main question addressed is whether reinterpretation, reformulation or replacement of Article 53 (c) of the European Patent Convention is viable and advisable. The issue is addressed by reference to both novel and resurfacing interpretative concerns connected with emerging technologies exemplified by nanomedicine, but also considerin

Cosmogenic radionuclides in environmental archives – A paleo-perspective on space climate and a synchronizing tool for climate records

Solen är den primära källan för jordens klimatsystem, som driver den atmosfäriska och oceana cirkulationen. Förutom att solens varierande instrålning påverkan jordens klimat, så bestämmer instrålningen även den atmosfäriska produktionen av kosmogena partiklar (t. ex. 10Be, 14C, 36Cl) som sedan lagras i diverse klimatarkiv på jorden. Förändringar i solinstrålningen över tid kan därför undersökas ocThe Sun is the primary source for Earth’s climate system. Its fluctuations in irradiance are also known to have an impact on climate. In addition, changes in solar activity modulate the atmospheric production rates of cosmogenic radionuclides (e.g. 10Be, 14C, 36Cl) that all eventually deposit to different environmental archives. The signal of the changing solar activity through time can thus be re

Assessment of Competence in EVAR Procedures : A Novel Rating Scale Developed by the Delphi Technique

OBJECTIVE/BACKGROUND: To develop a procedure specific global rating scale for assessment of operator competence in endovascular aortic repair (EVAR).METHODS: A Delphi approach was used to achieve expert consensus. A panel of 32 international experts (median 300 EVAR procedures, range 200-3000) from vascular surgery (n = 21) and radiology (n = 11) was established. The first Delphi round was based o

Essays on Incomplete Information in Financial Markets

Popular Abstract in Swedish Avhandlingen består av tre essäer som behandlar effekterna av inkomplett information i de finansiella marknaderna. Av dessa essäer är två teoretiska och en är huvudsakligen empirisk. Samtliga essäer undersöker effekterna av parameterosäkerhet, och de använder sig av kontinuerliga modeller. Den första essän, "The Effect of Information Quality on Optimal Portfolio ChoiceThis thesis consists of three essays on incomplete information in financial markets, two of which are theoretical, and one that is mainly of an empirical nature. All three essays concern parameter uncertainty, and they employ a continuous-time framework. The first essay, "The Effect of Information Quality on Optimal Portfolio Choice," analyzes the portfolio choices made by three types of agents,