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Tumor growth rate estimations in a breast cancer screening population

Tumor growth rate estimations can provide useful information about tumor progression and aggressiveness. Understanding the breast cancer progression and aggressiveness could aid with personalized screening/follow-up, treatment options, and prognosis. This paper reports a preliminary estimation of the tumor volume doubling time (TVDT) for cancers detected during the Malmö Breast Tomosynthesis Scree

Evaluation of a flat fielding method for simultaneous DBT and MI acquisition

We are developing a prototype system for simultaneous digital breast tomosynthesis (DBT) and mechanical imaging (MI). MI maps the local pressure distribution during clinical exams, to distinguish breast abnormalities from the normal tissue. Both DBT alone, and MI when combined with digital mammography, have demonstrated the ability to reduce false positives; however, the benefit of combining DBT w

Evaluation of 3D printed contrast detail phantoms for mammography quality assurance

Objects created by 3D printers are increasingly used in various medical applications. Today, affordable 3D printers, using Fused Deposition Modeling are widely available. In this project, a commercially available 3D printer was used to replicate a conventional radiographic contrast detail phantom. Printing materials were selected by comparing their x-ray attenuation properties. Two replicas were p

Pain prevalence and pain relief in end-of-life care - a national registry study

BACKGROUND: Despite pain control being a top priority in end-of-life care, pain continues to be a troublesome symptom and comprehensive data on pain prevalence and pain relief in patients with different diagnoses are scarce.METHODS: The Swedish Register of Palliative Care (SRPC) was used to retrieve data from 2011 to 2022 about pain during the last week of life. Data were collected regarding occur

Social sårbarhet utifrån ett medborgarperspektiv.

När extraordinära händelser inträffar, handlar de akuta insatserna för de drabbade om livräddning och akutsjukvård. Annan praktisk hjälp t.ex. att åtgärda vattenförsörjning och återställa infrastruktur ingår i kommunernas och andra myndigheters insatser. Sedan slutet av 1980-talet har även det psykologiska och sociala stödet uppmärksammats. I samband med s.k. Kistaolyckan 1988, då skolelever dog i

Imaging the master regulator of the antioxidant response in non-small cell lung cancer with positron emission tomography

Mutations in the NRF2-KEAP1 pathway are common in non-small cell lung cancer (NSCLC) and confer broad-spectrum therapeutic resistance, leading to poor outcomes. The cystine/glutamate antiporter, system xc-, is one of the >200 cytoprotective proteins controlled by NRF2, which can be non-invasively imaged by (S)-4-(3-18F-fluoropropyl)-l-glutamate ([18F]FSPG) positron emission tomography (PET). Throu

Impacts of vehicle fleet electrification in Sweden-a simulation-based assessment of long-distance trips

Electrifying road transport is seen as one of the key components in decreasing the carbon footprint of the society as a whole. Recent developments in electric drivetrain and battery technology have helped to design vehicles with ranges that make them independent of public charging infrastructure during most sub-urban and commuting trips. Once long-haul trips are planned, however, these vehicles re

Evaluating an image restoration pipeline for digital mammography across varied radiation exposures and microcalcification sizes using model observer analysis

In this study, we assess the impact of an image restoration pipeline, designed for digital mammography, on the detectability of microcalcifications of different sizes across varied radiation exposures. The restoration pipeline first removes the noise of the image considering a Poisson-Gaussian noise model that incorporates quantum and electronic noise. Then, it appropriately merges the noisy and d

Scaling extreme programming in a market driven development context

This paper briefly summarizes a research project aiming at analyzing the scaling up of extreme programming (XP) in a market driven context for embedded software and the integration of XP towards management processes in this context. Both the scaling of XP and market driven software development issues are not addressed by the original XP methodology as it relies on developing software by simplifyin

Riskhantering i en socken

Vårt syfte med detta kapitel är att beskriva och analysera krisförberedande arbeten i en landsortsby från en lokal risk- och sårbarhetsgrupps perspektiv samt tydliggöra olika drivkrafter, förutsättningar och relationer med myndigheter och andra aktörer. Underlaget för kapitlet utgörs av en intervju med representanter för den lokala gruppen i en socken i Kronobergs län, en enskild intervju med en n

An alarm reduction application at a district heating plant

The proper handling of alarms is crucial to any automated process control. In practice, many alarms are only distractive and do not represent a fault situation. In an ongoing project a computerized tool is applied, that aims to remove such nuisance alarms, a so-called alarm cleanup. This is a general, systematic approach that takes advantage of the control system's built-in functions, and is a fir