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A great challenge during early development of medicinal antibodies is to determine the stability of the candidates. This is required to be able to select the candidates with the greatest developability. The stability of the candidates can be estimated using different orthogonal techniques and the aim of this investigation was thus to use orthogonal techniques for the investigation of conformationa
This thesis aims to determine whether there is a human right to education in mother tongue for national minorities in international as well as regional human rights law. Its goal is to contribute to the existing research by evaluating and assessing the available treaties as well as non-binding documents issued by United Nations, Council of Europe and Organization for Security and Co-operation in E
With the emergence of the digital spaces, modern society has been witnessing the transformation of the public sphere, which is mostly altered by the new means of communication. Simultaneously, civic discussions that are taking place within the public sphere, are inevitably going through the same transformation and are now more and more often found in the digital spaces. This thesis is taking on th
As the negative environmental impacts of contemporary agriculture become still more evident and widespread, the question of how to feed future generations while preserving the vital stability of the planet’s environment is more urgent than ever. Major institutions are targeting the environmental sustainability of agriculture, internationally as well as in Brazil. Brazil is one of the largest agric
Abstract The world has seen three industrial revolutions and now it embraces the fourth. The fourth industrial revolution, (globalisation 4.0) or as this study uses industry 4.0, follows onto the third industrial revolution by connecting digital, material and living spheres. The narrative of Africa rising, and the related expansion of mobile phone motivated the thesis interest. As past development
I den exklusiva ekonomiska zonen har kuststaten suveräna rättigheter att utforska, exploatera, bevara och hantera de naturliga resurserna, levande eller icke-levande. Detta stadgas i de Förenta Nationernas Havsrättskonvention. I den exklusiva ekonomiska zonen har även andra stater vissa friheter, som typiskt sett åtnjuts på de fria haven, där ingen stat har jurisdiktion bortsett från flaggstaten oIn the exclusive economic zone a coastal State enjoys the sovereign rights to explore, exploit, conserve and manage the natural resources, whether living or non-living. That is provided by the United Nations Convention on the Law of the Sea. Also in the exclusive economic zone other states enjoy freedoms typically known for the high seas, were no state has jurisdiction apart from the flag State of
To address climate change, global greenhouse gas (GHG) emissions in the residential building sector, accounting for 39% in Sweden, need to reduce. While technological improvements and behavioural change are two commonly used strategies, the former is limited by rebound effects that range from 15-20% in Sweden. Focussing on individual behaviour is imperative. While Psychology (behavioural-based) an
This thesis employs a historical institutionalist lens to analyze whether the gendered impacts of COVID-19 have initiated a critical juncture in The Hunger Project’s program policy. Crises such as COVID-19 may lead actors within organizations to question existing policies, giving them greater opportunities than normal to transform these, with lasting consequences. Theory-testing process-tracing is
Att härleda ett internationellt illegalt handlande till en viss stat och hålla denna ansvarig är ett komplext problem i folkrätten. Det oklara rättsläget kompliceras ytterligare när aspekter av cyberoperationer introduceras med den snabba globala teknologiska utvecklingen. Rättsläget som det ser ut just nu är baserat på doktrin och sekundärrätt, där vikt läggs vid den tekniska bevisningen för att Attributing internationally wrongful acts to a particular State and liability is a complex problem in international law. The already unclear legal situation is further complicated when aspects of cyber operations are introduced with the rapid global technological development. To hold a State liable for the actions of non-State actors in cyberspace, we can only use secondary law and doctrine. The l
Micropollutants, such as pharmaceutical residues, are increasingly prevalent in water sources, posing significant risks to human and animal health while contributing to antimicrobial resistance. Despite high-standard wastewater treatment across the EU, the effective removal of micropollutants requires the adoption of more advanced treatment technologies, specifically quaternary treatment technolog
I examensarbetet analyseras och utvecklas en alternativ process vid utlösning av larm i en bostad, där grannar uppmanas samverka med hjälp av ett larmprogram. Larmföretaget Trex, uppdragsgivaren till arbetet undrar om det är möjligt att med hjälp av Skype skapa en tjänst som liknar denna alternativa process. Den tilltänkta tjänsten inleds med att en kund får vetskap om att larmet i dennes bostad u
The Genuine Progress Indicator (GPI) is a tool for measuring the wellbeing of an economy. The question of how to include the use of renewable energy sources is important when estimating the GPI for an economy highly dependent on renewable energy like Iceland. An analysis of GPI estimations showed that the use of renewable energy sources is reflected by the subtraction of the use of non-renewable o
Assembly of the mitochondrial respiratory chain requires the coordinated synthesis of mitochondrial and nuclear encoded subunits, redox co-factor acquisition, and correct joining of the subunits to form functional complexes. The conserved Cbp3-Cbp6 chaperone complex binds newly synthesized cytochrome b and supports the ordered acquisition of the heme co-factors. Moreover, it functions as a transla
Introduction: The objective of this study was to assess the usefulness of the appropriate use criteria (AUC) for amyloid imaging in an unselected cohort. Methods: We calculated sensitivity and specificity of appropriate use (increased confidence and management change), as defined by Amyloid Imaging Taskforce in the AUC, and other clinical utility outcomes. Furthermore, we compared differences in p
OBJECTIVE: To explore stroke survivors' experiences of healthcare-related facilitators and barriers concerning return to work after stroke. DESIGN: A qualitative study. SETTING: Outpatient stroke rehabilitation unit at a University Hospital in southern Sweden. PARTICIPANTS: A convenient sample of 20 persons admitted to Skåne University Hospital for acute stroke care (median age 52 years), in emplo
Given the growing use of cerebrospinal fluid (CSF) beta-amyloid (Aß) and tau as biomarkers for early diagnosis of Alzheimer's disease (AD), it is essential that the diagnostic procedures are standardized and the results comparable across different laboratories. Preanalytical factors are reported to be the cause of at least 50% of the total variability. Among them, diurnal variability is a key issu
Background: It is well known that women suffer from negative consequences following breast cancer (BC) treatment and that their largely varying needs for rehabilitation are often unmet. Up to 43% of these women are at risk of developing chronic distress requiring complex interventions; however, how to early identify and meet these women's needs is unknown, leaving them with suboptimal chances of r
Civil society organizations have distinctive roles to play in everysociety. They collectively contribute to the very communal fabric thatenables a dynamic social contract, and provide the space and the opportunityfor matters not easily handled in the other spheres of society.In those roles civil society is also a crucial part in the resilience of anysociety and a key force in its capacity to cope
INTRODUCTION: First-trimester pregnancy risk evaluation facilitates individualised antenatal care, as well as application of preventive strategies for pre-eclampsia or birth of a small for gestational age infant. A range of early intervention strategies in pregnancies identified as high risk at the end of the first trimester has been shown to decrease the risk of preterm pre-eclampsia (<37 gestati
Background: Glenohumeral osteoarthritis can, in the most severe cases, require surgery with insertion of a shoulder arthroplasty. A design with a stem in the humeral bone canal is currently regarded as the standard treatment option in patients who have an intact rotator cuff function, but complications related to the stem including humeral fractures can have devastating consequences. By using a st
