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How is it that a group that self-identifies as “religious” and is associated with one of the most dramatic events in the United States during the 1980s could receive almost no attention from religious studies scholars? Furthermore, how is it that the court case in which said group was determined to not qualify as a “religion” has been discussed and challenged by legal scholars while being virtuall
Heart failure (HF) is a major public health problem characterized by inability of the heart to maintain sufficient output of blood. The systematic characterization of circulating proteins across different stages of HF may provide pathophysiological insights and identify therapeutic targets. Here we report application of aptamer-based proteomics to identify proteins associated with prospective HF i
PURPOSE: Invasive lobular carcinoma (ILC) is a subtype of breast cancer accounting for 10% of breast tumors. The majority of patients are treated with endocrine therapy; however, endocrine resistance is common in estrogen receptor-positive breast cancer and new therapeutic strategies are needed. Bromodomain and extraterminal inhibitors (BETi) are effective in diverse types of breast cancer but the
The paper presents digital nomads’ experiences about the support of digital technologies in relation to social isolation. Despite the abundant access to digital technologies for organizational cooperative purposes, the challenge of social isolation constitutes one of the central concerns in nomadicity practices, affecting employees’ choice of working arrangements. To gain further knowledge on the
On-demand droplet generation from a continuously flowing stream of aqueous phase has profound applications in dropletbased microfluidics for rare event encapsulation studies. Here, we present acoustic relocation-based droplet generation from co-flowing immiscible fluids in an on-demand manner using bulk acoustic wave (BAW). After on-demand droplet generation, droplets are isolated using the same a
The process of selecting requirements for a release of a software product is challenging as the decision-making is based on uncertain predictions of customer value and development cost. This paper presents a method aimed at supporting software product development organisations in the identification of process improvement proposals to increase requirements selection quality. The method is based on
This article examines the portrayal of bodily boundaries in the videogame series The Last of Us. Drawing on theories of media ecology and posthumanism (most notably Deer’s notion of radical animism, Haraway’s theories of the cyborg, and Fuller’s account of media assemblages), three aspects of this portrayal are described: first, the game’s narrativization of bodily violence through an amalgamation
An implementation of a self-tuning regulator is described. The regulator algorithm consists of two steps. Firstly the parameters of a model of the process are estimated in real time using the method of least squares. Secondly a minimum variance regulator based on the estimated parameters is computed at each sampling interval. Implementation of the algorithm on a process computer is discussed. Ques
The main purpose of the paper is to explore the importance of stakeholders' interaction in the different stages of the implementation process of city logistics initiatives and to assess the extent to which interaction may vary between two apparently similar initiatives. A comparative, longitudinal study, with data from two Swedish city logistics initiatives is conducted. The findings highlight the
Heart failure (HF) is a leading cause of morbidity and mortality worldwide. A small proportion of HF cases are attributable to monogenic cardiomyopathies and existing genome-wide association studies (GWAS) have yielded only limited insights, leaving the observed heritability of HF largely unexplained. We report results from a GWAS meta-analysis of HF comprising 47,309 cases and 930,014 controls. T
Genome wide association studies (GWAS) have mapped multiple independent cancer susceptibility loci to chr5p15.33. Here, we show that fine-mapping of pancreatic and testicular cancer GWAS within one of these loci (Region 2 in CLPTM1L) focuses the signal to nine highly correlated SNPs. Of these, rs36115365-C associated with increased pancreatic and testicular but decreased lung cancer and melanoma r
Triple-negative breast cancer (TNBC) is the most lethal subtype of breast cancer with high heterogeneity and poor therapeutic responses to standard treatments. The use of herbal medicine for treatment of TNBC is gaining in popularity worldwide due to their better anti-tumor efficacy and less side effects compared to chemotherapy agents. Previous studies have shown that crocin, a natural carotenoid
Diamond-Blackfan anemia (DBA) is a bone marrow failure syndrome caused by mutations in ribosomal protein genes. Pathogenic mechanisms are poorly understood but involve severely reduced proliferation of erythroid precursors. Because current DBA therapies are ineffective and associated with severe side effects, disease-specific therapies are urgently needed. We hypothesized that druggable molecular
Purpose To investigate multivoxel proton Magnetic Resonance Spectroscopy (1HMRS) biometrics for preoperative differentiation and prognosis of patients with brain metastases (MET), low-(LGG) and high grade glioma (HGG). Methods Thirty-five patients (15 HGG, 9 LGG and 11 MET) were included. Proton Magnetic Resonance Spectroscopy Imaging(1H-MRSI) data was assessed and neurochemical profiles for metab
Wave cycles, i.e. pairs of local maxima and minima, play an important role in many engineering fields. Many cycle definitions are used for specific purposes, such as crest-trough cycles in wave studies in ocean engineering and rainflow cycles for fatigue life prediction in mechanical engineering. The simplest cycle, that of a pair of local maximum and the following local minimum is also of interes
This thesis explores different models of random graphs. The first part treats a change from the preferential attachment model where the network incorporates new vertices and attach them preferentially to the previous vertices with a large number of connections. We introduce on top of this model the deletion of the oldest connections in the system and discuss the impact on the degree of the vertice
A major component of aircraft noise is the jet noise created by the high velocity hot stream exhausting from a jet engine, interacting with itself and with the surrounding cold air. In the present paper the flow and acoustic fields that are generated by two coaxial jets are considered. Numerically, the problem is divided into a flow related part (Navier-Stokes system of equation) and an acoustic p
We study how processing states alternate during information search tasks. Inference is carried out with a discriminative hidden Markov model (dHMM) learned from eye movement data, measured in an experiment consisting of three task types: (i) simple word search, (ii) finding a sentence that answers a question and (iii) choosing a subjectively most interesting title from a list of ten titles. The re
Cyclodextrin glycosyltransferases (CGTases) from Paenibacillus macerans, Thermoanaerobacter sp. ATCC 53627, Bacillus stearothermophilus and a Carboxydocella sp. (phylogenetically identified from genomic DNA) were characterized with respect to their catalytic activity in different reactions, with emphasis on reactions useful for the elongation of the carbohydrate group of alkyl glycosides. All CGTa
Architects have a key role to play when it comes to the design of future low-energy (solar) buildings. Proper design tools and working methods could help architects in the design process. In order to identify barriers of existing tools and methods for solar design, needs of architects for improved tools, and to gain an insight into architects’ methods of working during the design process, an inter
