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Purpose Previous research shows that the death of a parent places children at risk for a number of negative outcomes. The role of trust in health care at the end of life has been acknowledged as crucial for patients and adult family members. However, the consequences of children’s distrust in the care provided to their parents remain unknown. Therefore, we investigated the negative long-term outco

Summary: This study aimed to investigate if high levels of blood cadmium at baseline were associated with increased fracture risk during follow-up in middle-aged women. No increased fracture risk was observed during follow-up, but women with higher levels of cadmium had an increased overall mortality. Introduction: Exposure to high levels of cadmium has been associated with an increased fracture r

Estimating glomerular filtration rate (GFR) in adults by using the average of values obtained by a cystatin C- (eGFRcystatin C) and a creatinine-based (eGFRcreatinine) equation shows at least the same diagnostic performance as GFR estimates obtained by equations using only one of these analytes or by complex equations using both analytes. Comparison of eGFRcystatin C and eGFRcreatinine plays a piv

Protein biomarkers for epithelial ovarian cancer are critical for the early detection of the cancer to improve patient prognosis and for the clinical management of the disease to monitor treatment response and to detect recurrences. Unfortunately, the discovery of protein biomarkers is hampered by the limited availability of reliable and sensitive assays needed for the reproducible quantification

FMS-like tyrosine kinase 3 (FLT3) is a receptor tyrosine kinase that is expressed almost exclusively in the hematopoietic compartment. Its ligand, FLT3 ligand (FL), induces dimerization and activation of its intrinsic tyrosine kinase activity. Activation of FLT3 leads to its autophosphorylation and initiation of several signal transduction cascades. Signaling is initiated by the recruitment of sig

Colorectal cancer (CRC) is the third most prevalent cancer worldwide causing an estimated 700 000 deaths annually. Different types of treatment are available for patients with advanced metastatic colorectal cancer, including targeted biological agents, such as cetuximab, a monoclonal antibody that targets EGFR. We have previously reported a study indicating multiple levels of interaction between m

Although invasive species are recognized as a major threat to freshwaters, little is known about how future climate warming will affect the success of invaders. Ecosystems are also often simultaneously impacted by multiple, potentially interacting, invading species and the management of species invasions can be incredibly difficult. Sensitive methods such as environmental DNA (eDNA) metabarcoding,

Well-characterized archival formalin-fixed paraffin-embedded (FFPE) tissues are of much value for prospective biomarker discovery studies, and protocols that offer high throughput and good reproducibility are essential in proteomics. Therefore, we implemented efficient paraffin removal and protein extraction from FFPE tissues followed by an optimized two-enzyme digestion using suspension trapping

In Sweden there are many laws that apply to government archives. Amongst them are the Public Access and Secrecy Act (offentlighets- och sekretesslagen) which regulates which records are bound by secrecy and which are rendered public. The Public Access and Secrecy Act frequently makes implicit references to a protection of integrity, particularly in its treaties on extradition. To investigate what

Kartlägga buskar på Öland för att rädda den biologiska mångfalden. På södra delen av Öland finns ett område som kallas Stora Alvaret som har mycket höga naturvärden. En minskning av betande djur under 1900-talet har dock gjort att den biologiska mångfalden hotas av buskar som sprider sig och utkonkurrerar andra växter. I examensarbetet Looking for shrubs in an alvar undersöker Jorun Westman metodeLoss of biodiversity is an immediate threat to the planet and if no actions are taken it is expected to accelerate. The highest species richness on smaller scale is found in semi-natural temperate grasslands, with one of the documented records from Stora Alvaret on Öland, Sweden. The area is protected under the Natura 2000-network and Länstyrelsen Kalmar are responsible for monitoring while local

Uppsatsen syftar till att utreda hur rättstillämpningen på S:t Barthélemy fungerade i förhållande till rättstillämpningen i Sverige. Genom en rättshistorisk metod och ett komparativt perspektiv undersöks skillnaderna och likheterna mellan de två rättssystemen. Frågan besvaras genom att närmare undersöka följande tre områden: domstolens sammansättning, lagstiftningen och rättskipningen. DomstolensThe thesis aims to investigate how the adjudication in St. Barthélemy functioned in relation to the adjudication in Sweden. The differences and similarities between the two legal systems are examined through a legal historical method and a comparative perspective. The question is answered by examining the following three areas: the composition of the court, the legislation, and the administration

Research question: How does organizational culture, using complex adaptive systems perspective, influence problem creation process in the front end of innovation? Theoretical perspectives: Front end of innovation literature is the core subject of this thesis,focusing on problem creation process. Academic literature on organizational culture and complex adaptive systems is presented to show the re

When China opened it borders in 1979, the country suffered from a severe brain drain as its most talented students left the country to take advantage of educational opportunities abroad. However these emigrant engineers, known locally as "sea turtles" or Chinese returnees, have become a valuable asset for Zhongguancun Science Park. The authorities for the high-tech park are now adopting

Antalet olovliga nyttjanden av ensamrätter har ökat under de senaste åren. En immateriell rättighet som inte kan skyddas mot intrång saknar i många avseenden värde. Tillgången av verkningsfulla och effektiva sanktioner är därför en nödvändighet. År 1994 infördes en ny sanktionsform i varumärkes-, mönster- och upphovsrättslagen, nämligen vitesförbud. Sanktionsformen skulle förse rättighetsinnehavarThe number of cases of infringements of intellectual property rights has increased in recent years. An exclusive right, which cannot be protected, lacks value in many aspects. Access to efficient and effective sanctions is therefore essential for rightsholders. In 1994, a new sanction in the Swedish copyright-, design- and trademark act was adopted. The Swedish legislator intended to provide right

Inom den europeiska politiken har det på senare år växt fram fler främlingsfientliga element. Många av dessa lägger tyngd på islam och muslimska kulturer som ett hot mot den europeiska välfärden och nationell identitet. British National Party är ett exempel på ett parti som sätter nationalism i första led och som är uppenbart främlingsfientliga. De lägger stor tyngd på att framställa islam och mus

Under "The Big Bang" så bildades den materia som idag utgör vårt universum. Enligt den teoretiska så kallade "Standardmodellen" i partikel fysik så skulle det i detta skede bildats lika mycket materia som antimateria. Men observationer idag visar sig att i princip all antimateria är på något vis bortkommet. Denna motsägelse av en annars väl bevisad teoretisk modell är något somThis work relates to the proposed n-nbar experiment at ESS and covers a procedure with which future neutron research can be made using a small TPC prototype. Settings for the GEM amplification voltage supply and main drift field across the chamber have been established using minimum ionizing cosmic muons as a reference. To be able to reconstruct tracks in three dimensions and measure the deposited

Background: Prostate cancer therapy with surgical or chemical castration with gonadotropin-releasing hormone (GnRH) agonists has been linked to elevated follicle-stimulating hormone (FSH) levels, which may contribute to secondary health disorders, including atherosclerosis and diabetes. Although recent findings suggest a role for FSH beyond the reproductive system, its metabolic impact remains unc

Recognizing Sepsis as a Global Health Priority — A WHO Resolution Perspective The NEW ENGLAND JOURNAL of MEDICINE n engl j med nejm.org 1 “Some very important clinical issues, some of them affecting life and death, stay largely in a backwater which is inhabited by academics and professionals and enthusiasts, dealt with very well at the clinical and scientific level but not visible to the public, p

https://www.sepsis.lu.se/sites/sepsis.lu.se/files/perspective_sepsis_nejmp1707170.pdf - 2026-04-30