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The combination of a negative D-dimer and a Wells score can rule out, but not confirm, a diagnosis of deep venous thrombosis (DVT). We aimed to identify new diagnostic biomarkers for DVT and to investigate their relationship with hypercoagulability markers [D-dimer and activated protein C-protein C inhibitor (APC-PCI) complex]. We screened 92 cardiovascular-specific proteins in plasma samples from
Background: Tyrosine kinase inhibitors (TKIs) have improved the survival of patients with chronic myeloid leukaemia. Many patients have deep molecular responses, a prerequisite for TKI therapy discontinuation. We aimed to define precise conditions for stopping treatment. Methods: In this prospective, non-randomised trial, we enrolled patients with chronic myeloid leukaemia at 61 European centres i
Understanding leukemia heterogeneity is critical for the development of curative treatments as the failure to eliminate therapy-persistent leukemic stem cells (LSCs) may result in disease relapse. Here we have combined high-throughput immunophenotypic screens with large-scale single-cell gene expression analysis to define the heterogeneity within the LSC-population in chronic phase chronic myeloid
Background: Natural killer (NK) cells and NK T cells (NKT) are vital parts of tumour immunosurveillance. However, their impact on prognosis and chemotherapy response in periampullary adenocarcinoma, including pancreatic cancer, has not yet been described. Methods: Immune cell-specific expression of CD56, CD3, CD68 and CD1a was analysed by immunohistochemistry on tissue microarrays with tumours fro
Återvätning av våtmark hämmas av markavattningsföretag En fjärdedel av Sveriges våtmark är avvattnad och detta kan ha gjorts med hjälp av markavvattningsföretag. Nu vill Sveriges regering återväta våtmarker men markavvattningsföretagen ligger som en blöt filt över processen. Faktum är att de kan vara den enda anledningen till att ett återvätningsprojekt läggs ner. Den absolut mest betydande probleWetlands are one of the most precious ecosystems in the world. They are important be-cause of their high biological diversity and unique properties, such as water purification and carbon sequestration. Yet, wetlands are also one of the most endangered ecosystems due to land draining. In Sweden, wetlands have been drained för centuries due to the lack of arable land. The draining can have been acco
Transcriptional profiling of epithelial ovarian cancer has revealed molecular subtypes correlating to biological and clinical features. We aimed to determine gene expression differences between malignant, benign and borderline serous ovarian tumors, and investigate similarities with the well-established intrinsic molecular subtypes of breast cancer.
Melanoma patients treated with oncogenic BRAF inhibitors can develop cutaneous squamous cell carcinoma (cSCC) within weeks of treatment, driven by paradoxical RAS/RAF/MAPK pathway activation. Here we identify frequent TGFBR1 and TGFBR2 mutations in human vemurafenib-induced skin lesions and in sporadic cSCC. Functional analysis reveals these mutations ablate canonical TGFβ Smad signalling, which i
Endometrial cancer risk prediction models including lifestyle, anthropometric and reproductive factors have limited discrimination. Adding biomarker data to these models may improve predictive capacity; to our knowledge, this has not been investigated for endometrial cancer. Using a nested case–control study within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, we
©2011 Landes Bioscience. Do not distribute. www.landesbioscience.com Cell Cycle 3311 Cell Cycle 10:19, 3311-3316; October 1, 2011; © 2011 Landes Bioscience RepORt RepORt *Correspondence to: Malin Parmar; Email: Malin.Parmar@med.lu.se Submitted: 07/28/11; Revised: 07/29/11; Accepted: 08/01/11 DOI: 10.4161/cc.10.19.17584 Induced pluripotent stem cells (iPS cells) obtained by repro- gramming of adult
https://www.regenerative-neurobiology.lu.se/sites/regenerative-neurobiology.lu.se/files/pfisterer.pdf - 2026-04-24
Cell‐based therapy for Parkinson's disease: A journey through decades toward the light side of the Force Eur J Neurosci. 2018;1–9. | 1wileyonlinelibrary.com/journal/ejn 1 | INTRODUCTION It was with great sadness that we all received the news about Tom’s passing. He was a force for good in the Parkinson’s disease (PD) community and he will be greatly missed. For Tom, nothing was too serious that yo
Järnbrist är idag ett växande problem, i både utvecklings- och industrialiserade länder, och uttrycker sig oftast genom att den drabbade individen känner sig trött och svag. Om sjukdomen däremot inte behandlas kan konsekvenserna bli större. Järn är nämligen en viktig komponent för produktion av röda blodkroppar, det vill säga blod, och fungerar som en syre-transportör till kroppens alla energidrivIron deficiency is the most common nutritional disorder in the world. It is the only nutrient deficiency that is not exclusively prevalent in non-industrialized nations but also in all industrialized countries. Despite this, the treatment for the disease is inefficient, long and associated with side effects such as constipation and nausea. In recent years several studies have highlighted the diffe
Uppsatsen ”’The promise of participation culture’: Publikens deltagande i crowdfundingskampanjer” är författad av Sergey Vasiliev under kursen i medie-och kommunikationsvetenskap, vid Institutionen för kommunikation och medier, Lunds universitet. Uppsatsen är en fallstudie av två framgångsrika med olikartade crowdfundingskampanjer, ”Veronica Mars Movie Project” och ”The Pirate Bay – Away From Key
Behovet av mer miljövänliga lösningar har aldrig varit större än idag. Mängden koldioxidutsläpp ökar ständigt, vilket leder till ökad mängd koldioxid i atmosfären. Vid tillverkning av plast används idag vanligtvis olja som råmaterial, men man kan använda biobaserat råmaterial i stället såsom socker. I Sverige produceras socker av sockerbetor. En restprodukt är då melass en tjock sirapsliknande socMolasses is a low value by-product from sugar production that is usually used for animal feed, bioethanol fermentation, and yeast growth substrate. Even though it is a by-product and most of the sugar have been taken out the molasses still contains a fair amount of sugar that can be used for production of HMF, a biobased platform chemical with many areas of application, for example as a feedstock
Idag används stål eller titan som fixtur för benbrott. Dessa måste opereras in, och efter läkning opereras ut igen. En kandidat att ersätta dessa material är Magnesium, vilken naturligt och ofarligt bryts ned i kroppen så en andra operation inte behövs. För att kunna designa en magnesiumlegering vilken kan användas som implantat vid benbrott måste vi förstå hur nedbrytningsprocessen går till. FörMagnesium alloys are promising candidates as biomedical implants. However, a good understanding of their degradation processes is lacking. In this work, degradation in two magnesium alloys were studied in a simple physiological-fluid electrolyte of H2O+0.9wt%NaCl, Mg-5wt%Zn (Z5) & Mg-5wt%Zn-0.3wt%Ca (ZX50). Z5 alloy was studied in two microstructural states, as-cast and as a supersaturated sol
The Commission has put forth a proposal for a Regulation on a Common European Law of Sales (CESL). It is envisaged – as of now – as an optional second regime within each member state‘s law, electable for transnational consumer contracts and contracts among traders, as long as one of them is a small or medium-sized enterprise. The intention is to provide contractors with a level playground of one l
Abstract in UndeterminedThe Base of the Pyramid (BoP) consists of about two-fifths of the world population. This population can be categorized as poor with income of less than 2 dollars per day. It is important to alleviate poverty. One of the promising approaches to tackle the wicked problem of poverty is business development combined with poverty alleviation. In this approach, integrated solutio
The described technical-economic model clarifies the influence of different production technological factors on the processing cost of a part. Influential factors can be weighted against each other, which leads to different production development scenarios and their effects on the processing cost can be studied. This implies a way to generate a basis of decision by which a company can base their p
