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Today, the majority of prostate tumours are detected at early stages with uncertain prognosis. Therefore, we set out to identify early predictive markers of prostate cancer with aggressive progression characteristics. We measured the expression of microRNAs (miRNA) using qRT-PCR in FFPE prostatic tissue samples from a Swedish cohort of 49 patients with prostate cancer and 25 without cancer and fou

Samverkan har sedan lång tid tillbaka varit viktigt inom både regionala ochkommunala verksamheter och det finns mycket som talar för attsamverkansbehoven kommer att öka än mer. Inom hälso- och sjukvården finns en kontinuerlig utveckling mot ny och mera specialiserad kunskap som även fårorganisatoriska konsekvenser. Teamarbete i vården har blivit allt viktigare, liksom nivåstrukturering och koncentCooperation has long been important within both regional andmunicipal activities and there is much to suggest thatcollaboration needs will increase even more. Within health care there is onecontinuous development towards new and more specialized knowledge that also gains organizational consequences. Teamwork in healthcare has become increasingly important, as well level structuring and concentrati

Purpose: There are concerns in the academic publishing community that it is becoming more difficult to secure reviews for scientific manuscripts. This study examines trends in editorial and peer review processes in an ophthalmological journal over the last decade. Methods: A retrospective analysis was performed of editorial data from the journal Acta Ophthalmologica containing all manuscript submi

BACKGROUND AND OBJECTIVES: Atrial fibrillation (AF) is associated with inflammation systemically and in the atrial tissue. Oxidized low-density lipoprotein (LDL) is increased in patients with AF and is suggested to be one of the molecules that drives inflammation. Autoantibodies against oxidized LDL and apolipoprotein B100, the protein component of LDL, are linked to atherosclerotic disease. Howev

Injectable bioelectronics could become an alternative or a complement to traditional drug treatments. To this end, a new self-doped p-type conducting PEDOT-S copolymer (A5) was synthesized. This copolymer formed highly water-dispersed nanoparticles and aggregated into a mixed ion-electron conducting hydrogel when injected into a tissue model. First, we synthetically repeated most of the published

Sedan 2015 har Sverige en uttalat feministisk utrikespolitik, med målet att ett genusperspektiv ska genomsyra all politisk verksamhet. Parallellt med denna nya politiska inriktning fortsätter Sverige att exportera krigsmateriel till icke-demokratiska och konfliktdrabbade stater, något som har gett upphov till kritik. Genom att granska den statliga myndighet som ansvarar för beslut om krigsmateriel

I takt med att tekniken går framåt blir den även vanligare i undervisningen. I dagsläget används IT som hjälpmedel på de flesta skolor och att elever ska lära sig att använda teknik är nu även en del av läroplanen. Då molntjänster har utvecklats och blivit en större del av våra privatliv så har de även senaste åren tagit sig in i skolan, även om det inte alla gånger varit lagligt. Tidigare forskni

Hypothesis: Sponge phase (L3) lipid nanoparticles (L3-NPs) have been shown to have large potential for the encapsulation of biomolecules, such as enzymes, with applications in food and pharmaceutical science. In this study, we introduce new formulations of L3-NPs including the phospholipids dioleoylphosphatidylcholine (DOPC) and dioleoyltrimethylammonium propane (DOTAP). The interaction of these n

Nowadays, many evacuation models exist in the market, and new models are continuously released with new features. How to assess the usability and reliability of model results becomes an issue for both developers and users. Therefore, verification and validation (V&V) protocols were introduced in the assessment process of evacuation models. To conduct V&V of a model, a widely accepted test

Connecting science to political agenda-setting is essential for a sustainable transition and acceptable politics. This task is complicated by phenomena like post-truth, for which facts are a non-issue. However, post-truth is not the only issue. The practice of political spin, in which the significance of facts is reconstructed according to specific interests poses another threat to scientific cred

Glykoprotein 2 – att skydda eller inte skydda, det är frågan. Glykoprotein 2 (GP2) är ett medfött protein som huvudsakligen produceras i bukspottkörteln och även finns på specialiserade tarm-epitelceller. Det delar likheter med ett annat protein som kallas för Tamm-Horsfalls protein (THP). Båda kan interagera med bakteriella fimbrier tex E. coli och Salmonella. THP kan därmed förhindra att E. coGlycoprotein 2 (GP2) is a glycosylphosphatidylinositol (GPI)-anchored protein primarily produced by pancreatic acinar cells. It is expressed on M cells and can interact with the type 1 fimbrial adhesin (FimH), a component of type 1 pili found in gram-negative bacteria e.g Salmonella. It shares homology to Tamm-Horsfall protein (THP) which has been shown to have antibacterial effects and can also i

Non-small cell lung cancer is the most common type of lung cancer. Both environmental and genetic risk factors contribute to lung carcinogenesis. We conducted a genome-wide interaction analysis between single nucleotide polymorphisms (SNPs) and smoking status (never- versus ever-smokers) in a European-descent population. We adopted a two-step analysis strategy in the discovery stage: we first cond

Globins are usually associated with oxygen carriage in vertebrates. However, plants also contain similar heme-containing proteins, called phytoglobins (Pgbs). Unlike conventional hemoglobin, these proteins are often linked to nitric oxide metabolism, energy metabolism and redox maintenance under hypoxic and related abiotic and biotic stress conditions. Class I and II non-symbiotic Pgbs (nsPgbs) ha

Background: Multidisciplinary team meetings (MDTMs) provide an integrated team approach to ensure individualized and evidence-based treatment recommendations and best expert advice in cancer care. A growing number of patients and more complex treatment options challenge MDTM resources and evoke needs for case prioritization. In this process, decision aids could provide streamlining and standardize

Here we studied the effects of glial cell line-derived neurotrophic factor (GDNF) in a rat model that represents the symptomatic stages of Parkinson's disease. GDNF was infused starting 2 weeks after an intrastriatal 6-hydroxydopamine (6-OHDA) lesion in order to halt the ongoing degeneration of the nigrostriatal dopaminergic neurons. GDNF or vehicle was infused in the striatum or the lateral ventr

Even though leukemia is considered to be confined to one specific hematopoietic cell type, cases of acute leukemia of ambiguous lineage and patients relapsing in phenotypically altered disease suggest that a malignant state may be transferred between lineages. Because B-cell leukemia is associated with mutations in transcription factors of importance for stable preservation of lineage identity, we