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LES of the flow and acoustics generated by an aircraft fan running in the vicinity of the ground

An important component of the aircraft generated noise, especially ahead of it, is the fan noise created by the high velocity variation near the blades and the interaction of the rotating fan with the fluid. In order to predict the sound, the method used involves the acoustical analogy developed by Ffowcs Williams and Hawkings. Computation of the flow field is performed in the incompressible LES f

Glucocorticoids improve erythroid progenitor maintenance and dampen Trp53 response in a mouse model of Diamond-Blackfan anaemia.

Diamond-Blackfan anaemia (DBA) is a rare congenital disease causing severe anaemia and progressive bone marrow failure. The majority of patients carry mutations in ribosomal proteins, which leads to depletion of erythroid progenitors in the bone marrow. As many as 40% of all DBA patients receive glucocorticoids to alleviate their anaemia. However, despite their use in DBA treatment for more than h

Template-Based Design Analysis – An Alternative Approach for the Engineering Designer to Perform Computer-Based Design Analysis

Popular Abstract in Swedish Vid framtagning av nya produkter måste man utgå ifrån de behov som den blivande kunden ställer i form av krav och önskemål på produkten för att den ska vara intressant att inhandla och använda. För att säkerställa att den blivande produkten har de egenskaper som efterfrågas, används idag omfattande simuleringar av den blivande produktens egenskaper. Simuleringar består The current trend in industry to encourage engineering designers to take an active part in the analysis of their own design solutions is apparent in many companies today, domestically as well as abroad. From a research project with the objective to develop a computer-based design system for the design of lightweight grippers, one of the major difficulties was to overcome the system users’ lack of

Developing a practice guideline for the occupational health services by using a community of practice approach : A process evaluation of the development process

Background: One way to facilitate the translation of research into the occupational health service practice is through clinical practice guidelines. To increase the implementability of guidelines it is important to include the end-users in the development, for example by a community of practice approach. This paper describes the development of an occupational health practice guideline aimed at the

A candidate CpG SNP approach identifies a breast cancer associated ESR1-SNP.

Altered DNA methylation is often seen in malignant cells, potentially contributing to carcinogenesis by suppressing gene expression. We hypothesized that heritable methylation potential might be a risk factor for breast cancer and evaluated possible association with breast cancer for single nucleotide polymorphisms (SNPs) either involving CpG sequences in extended 5'- regulatory regions of candida

A Taxonomy for Requirements Engineering and Software Test Alignment

Requirements Engineering and Software Testing are mature areas and have seen a lot of research. Nevertheless, their interactions have been sparsely explored beyond the concept of traceability. To fill this gap we propose a definition of requirements engineering and software test (REST) alignment, a taxonomy that characterizes the methods linking the respective areas, and a process to assess alignm

Benchmarking och Produktutveckling - Fimms det ett samband

Syfte: Vårt övergripande syfte med den här uppsatsen är att analysera och beskriva sambandet mellan produktutveckling och benchmarking. Resultat: Resultat av studien visar att det finns ett samband mellan benchmarking och produktutveckling. Benchmarking är en integrerad del i produktutvecklingsprocessen. Vi har kommit fram till fem gemensamma faktorer; Projektering, Målsättning, Implementering, Ut

The Carrot and the Stick: Changing Policy for Waste Management in a Swedish Municipality - A case study

Despite policy efforts to reduce waste and to recycle material, household waste in Europe continues to grow. In Sweden, most 290 municipalities use volume-based tariffs for household waste management. This report is about two alternative policies for household waste: (1) a weight based waste system and (2) a system of kerbside containers for sorted waste (FNI). It is a case study of policy develo

Understanding of Entrepreneurial Learning

Understanding of entrepreneurial learning has become an increasingly emphasized topic. Many studies have been made and many theories have been proposed. In this study I analyze entrepreneurial learning through a number of different models using my own experience as data. I try to seek an understanding of how the frameworks fit on my own experiences. For creating a better understanding of entrepren

The trustworthiness of anonymous eWOM

The main purpose of this research essay is to understand why and to what extent consumers trust anonymous eWOM. Secondly, it aims to understand what role anonymous eWOM has on the consumer’s purchase decision. A qualitative approach were used where data is collected through semi-structured interviews. The research is conducted with a phenomenological method in combination with an abductive work ap

Galectin-1-binding glycoforms of haptoglobin with altered intracellular trafficking, and increase in metastatic breast cancer patients.

Sera from 25 metastatic breast cancer patients and 25 healthy controls were subjected to affinity chromatography using immobilized galectin-1. Serum from the healthy subjects contained on average 1.2 mg per ml (range 0.7-2.2) galectin-1 binding glycoproteins, whereas serum from the breast cancer patients contained on average 2.2 mg/ml (range 0.8-3.9), with a higher average for large primary tumour

Methodology for Assessing Learning from Incidents - a Process Industry Perspective

Popular Abstract in Swedish Stora resurser används i processindustrin, och i många andra industribranscher, på att rapportera incidenter för att utnyttja erfarenheterna från dessa för att förebygga framtida incidenter – alltifrån mindre störningar till olyckor med stora konsekvenser. Det finns emellertid en hel del som tyder på att man ofta utnyttjar bara en del av hela den potential för lärande sLearning from incidents (from minor disturbances to major accidents) is considered one of the most important ways in the process industry to learn from experiences for improving safety performance. Most companies have a formal incident learning system and considerable resources are used for reporting incidents and for utilising these experiences to prevent future incidents. However, there are many

Life Stories and Christian Zionist Ideology : A Theoretical Outline of How to Capture the Interplay between Individual and Ideology

Christian Zionism is usually characterized as a theological and political movement grounded in literalist bible hermeneutics and End-time speculations that dedicate unwavering support to the State of Israel and the Jewish people. The prophetic element in Christian Zionism has in later years been downplayed for a more down-to-earth focus on social and political commitment to the well-being of the s

Establishing a Southern Swedish Malignant Melanoma OMICS and Biobank Clinical Capability

Background: The Southern Swedish Malignant Melanoma (SSMM) research team is a truly cross functional group with members from oncology, clinical, surgery, bioinformatics, proteomics, and genomics initiatives. The SSMM’s objectives and goals are to develop, build and utilize cutting edge biobanks and OMICS platforms to better understand disease pathology and drug mechanisms. Within the research team

Synthesis, regulation and production of urokinase using mammalian cell culture: A comprehensive review

Urokinase, a serine protease, catalyzes the conversion of plasminogen to plasmin, which is responsible for dissolution of clots in blood vessels. It is an important drug for treatment of thromboembolic disease. Production of urokinase by mammalian cell culture has the following important steps: synthesis, regulation and secretion. Production and accumulation of this product in a bioreactor is a re

Effects on Cardiac Dimensions and Peak Oxygen Uptake After Long-Term Deconditioning in Elite Athletes

This longitudinal observational study aimed to determine if ventricular dimensions of the athlete's heart remain balanced and proportional to peak oxygen uptake (VO2peak) following long-term deconditioning in elite athletes. Fourteen mixed-type male athletes (7 soccer, 7 handball players) were prospectively evaluated with cardiac magnetic resonance imaging and cardiopulmonary exercise testing whil