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INTRODUCTION: Monocytes are key effector cells in inflammatory processes. We and others have previously shown that synovial monocytes in childhood-onset arthritis are activated. However, very little is known about how they contribute to disease and attain their pathological features. Therefore, we set out to investigate the functional alterations of synovial monocytes in childhood-onset arthritis,

OBJECTIVES: Early diagnostic separation between glioblastoma (GBM) and solitary metastases (MET) is important for patient management but remains challenging when based on imaging only. The objective of this study was to assess whether amide proton transfer weighted (APTw) MRI alone or combined with dynamic susceptibility contrast (DSC) MRI parameters, including cerebral blood volume (CBV), cerebra

BackgroundThe risk of developing Alzheimer’s disease (AD) is modulated by genetic and environmental factors. Early-life stress (ELS) exposure during critical periods of brain development can impact later brain function and health, including increasing the risk of developing AD. Microglial dysfunction and neuroinflammation have been implicated as playing a role in AD pathology and may be modulated

Seaweeds and marine invertebrates of the lagoons and reefs have, ever since the initial settlement almost 3.500 years ago, been a very important source of food and raw materials for the people of the Tongan islands. This study is an attempt to combine anthropological and biological perspectives in documenting and discussing, in contemporary as well as ancient contexts, the gathering/collecting of

Snö, glaciärer och regn över bergsområden möjliggör dricksvatten för miljoner av människor och fungerar som vattenreservoar för hela ekosystem. Under rådande klimatförändringar har smältande glaciärer i Himalaya blivit ett känt hot mot framtida dricksvattenförsörjning, men glaciärerna är inte de enda processer som påverkar tillgången på vatten. För att ta beslut som säkrar framtida vattentillgänglIn the central Himalayas, water dynamics are expected to change due to multiple factors like climate change, hydro power development and shifting land use practices. This thesis looks at possible changes in water dynamics in Marsyandi river basin, Nepal, as well as causes to those changes and how they are perceived locally. Grounded in critical physical geography, the study uses mixed methods an

Titel: Det svenska börsintroduktionspusslet Seminariedatum: 17/01/2020 Kurs: FEKH89 Kandidatuppsats i Finansiering, 15hp Författare: Carl-Magnus Andersson, Josephine Nilsson, Nicholas Wikman Handledare: Maria Gårdängen Nyckelord: IPO, Underprissättning, Långsiktig underprestation, Förstadagsavkastning, Cyklikalitet, Nasdaq OMX Main Market, BHAR Syfte: Att undersöka förekomsten av underprissättningTitle: Det svenska börsintroduktionspusslet Seminar Date: 17/01/2020 Course: FEKH89 Kandidatuppsats i finansiering, 15hp Authors: Carl-Magnus Andersson, Josephine Nilsson, Nicholas Wikman Advisor: Maria Gårdängen Key words: IPO, Underpricing, Long run performance, Initial return, Nasdaq OMX Main Market, BHAR Purpose: To investigate the underpricing and long run performance of IPOs on Stockholm Mai

Efter att ha sett allt fler ladugårdar som förfaller bestämde jag mig för att göra ett arbete om just denna byggnad. Jag ville undersöka vad ladugården är och hur det kan vara möjligt att bevara och ta hand om den. Genom att skaffa kunskap om ladugårdens historia ville jag få en fördjupad insikt om vad dessa byggnader egentligen har för betydelse. Med hjälp av referensprojekt och genom att gestalAfter seeing more and more barns decaying, I decided to make a project about this particular building. I wanted to investigate what the barn is and how it may be possible to preserve and take care of it in the future. By gaining knowledge about the barn’s history, I got a in - depth insight into what these buildings really mean. By looking at reference projects and by transforming a existing barn,

The thesis aims to: (a) broaden the knowledge base that makes up the foundation for decisions with regard to how traffic law enforcement is best outlined, as well as increasing the understanding of how the shaping of different public instruments of control affects the chances of success; and (b) contribute to the development of theory and methodology within sociology of law. The relationship betwe

Climate change and disasters pose a serious risk to sustainable development. In the South local coping strategies are an important element of adaptation to climate and disaster risk. Such strategies have arisen because of the limited assistance provided by urban actors and associated social security and governance systems. In contrast, in the North local coping strategies are comparatively poorly

Many countries have established disaster risk management systems. These systems involve various parties and aim to maximize resources and use their diverse expertise to manage disaster risks. In such systems, sharing risk and vulnerability assessments (RVAs) between stakeholders is the most common way to communicate risk-related information. This study investigates communication challenges linked

Emergency and crisis management research is tightly coupled to practical problems. Yet, within that research tradition, surprisingly little has been done in terms of developing a practice of design research. The present report presents literature surveys aimed at investigating how, and to what extent, such research has been conducted. Although the focus is on command and control problems the mater

Codifications of human rights are widely understood as politically established instruments for evaluating human life. The call for such an apparatus emerges as a response to the age-old problem of social organization, constituting – in extension – a means by which to cope with the overall problem of survival. However, evaluating life is inherently problematic. It is problematic as it presupposes a

The Wilms tumor gene (WT1) encodes a zinc-finger containing transcription factor present in primitive hematopoietic progenitor cells. WT1 is also highly expressed in most cases of acute myeloid leukemia. Moreover, WT1 can interfere with induced differentiation of leukemic cell lines. These data suggest a function of WT1 in the maintenance of a primitive phenotype and a role in leukemogenesis by in