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In this work we present an integrated system for whole chromosome analysis of single bacterium. Using whole genome barcoding techniques, which offer direct and rapid microscopic visualization of the entire genome in one field-of-view, we aim to rapidly identify individual bacterium. We are developing our device to achieve the crucial, and difficult process of isolating a bacterium, removing the DN
Denna debattartikel argumenterar för att socialt arbete och socialtjänst behöver utvecklas i förhållande till digitalisering. Som ett led i ett samarbetsprojekt mellan Lunds universitet och Helsingborg stad, finansierat av både Vinnova och Helsingborg stad, skriver företrädare för både universitet och stad en debattartikel i DN. Hur kan socialtjänsten utvecklas med hjälp av digitalisering - nu och
Objective:: The loss of a parent to cancer is considered one of the most traumatic events a teenager can experience. Studies have shown that teenagers, from the time of diagnosis, are already extremely worried about the consequences of a parent's cancer but tend to be left to manage these concerns on their own. The present study aimed to explore young adults' advice to healthcare professionals on
Using Deterministic Lateral Displacement (DLD), we are able to separate bacteria by their size and their chain length. This separation enables the study of these properties as factors of virulence.
Background: Atrial fibrillatory cycle length has been considered one of the indices of atrial electrical remodelling during atrial fibrillation (AF), which can be assessed from surface ECG by computer-assisted calculation of atrial fibrillatory rate (AFR). Horses have been suggested as a bona fide model for AF studies since horses too, develop lone AF, however data on AF characteristics in horses
Circulating proteins are vital in human health and disease and are frequently used as biomarkers for clinical decision-making or as targets for pharmacological intervention. Here, we map and replicate protein quantitative trait loci (pQTL) for 90 cardiovascular proteins in over 30,000 individuals, resulting in 451 pQTLs for 85 proteins. For each protein, we further perform pathway mapping to obtai
BACKGROUND: Highly increased risk of injuries has been noted around the time of cancer diagnosis. Whether there is a similar increase in risk around the diagnosis of cervical cancer and its precursor lesions was unknown.METHODS: We performed a cohort study including 3,016,307 Swedish women that participated in cervical screening during 2001 to 2012. We calculated the incidence rates (IR) of hospit
Background: Incidental gallbladder cancer (IGBC) is an unexpected finding when a cholecystectomy is performed upon a benign indication, and the use of routine or selective histological analysis of gallbladder specimen is still debated. The aim of this study was to investigate whether the proportion of submitted gallbladder specimens for pathological investigation influences the proportion of IGBC
BACKGROUND: Postural orthostatic tachycardia syndrome (POTS) is a variant of cardiovascular (CV) autonomic disorder of unknown etiology characterized by an excessive heart rate increase on standing and orthostatic intolerance. In this study we sought to identify novel CV biomarkers potentially implicated in POTS pathophysiology.METHODS: We conducted a nested case-control study within the Syncope S
Progranulin is a secreted protein with important functions in processes including immune and inflammatory response, metabolism and embryonic development. The present study aimed at identification of genetic factors determining progranulin concentrations. We conducted a genome-wide association meta-analysis for serum progranulin in three independent cohorts from Europe: Sorbs (N=848) and KORA (N=16
PURPOSE: miRNAs play a prominent role in a variety of physiologic and pathologic biologic processes, including cancer. For rectal cancers, only limited data are available on miRNA expression profiles, whereas the underlying genomic and transcriptomic aberrations have been firmly established. We therefore, aimed to comprehensively map the miRNA expression patterns of this disease. EXPERIMENTAL DE
Proteiner är några av livets beståndsdelar. Komplexa molekyler som förser våra kropparmed både struktur och funktion, bland annat i muskler. De är kedjor av aminosyror,som vartefter de skapas i kroppen ofta veckar sig till en specifik tredimensionell strukturför att kunna utföra den funktion de har optimerats för under evolutionens gång.Uppstår fel i denna process kan felaktiga strukturer, som oftA protein chain often folds into a functional, specific three dimensional structure. Failurein this process can in some cases lead to disease, e.g. the misfolding disease ALS. Themechanisms behind the folding has mostly been studied under dilute conditions. However,in the natural cellular environment of proteins, the concentration of macromolecules is highand it is believed that this affects vario
Objectives. The treatment of eating disorders is a complex process that relies not only on the use of psychotropic drugs but should include also nutritional counselling, psychotherapy and the treatment of the medical complications, where they are present. In this review recommendations for the pharmacological treatment of eating disorders (anorexia nervosa (AN), bulimia nervosa (BN), binge eating
Popular Abstract in Swedish Jäst kan antingen bryta ner socker direkt till koldioxid och vatten genom andning, eller indirekt via koldioxid och etanol, genom jäsning. Andning är en process som förbrukar syre, och sker därför endast under syrerika (aeroba) förhållanden. Jäsning kräver till skillnad från andning inte tillgång till syre, och kan därför ske under syrefattiga (anaeroba) förhållanden. Under aerobic conditions, most yeasts such as Kluyveromyces lactis, prefer the respiratory pathway and some, such as Saccharomyces cerevisiae prefer less energy efficient fermentative pathway for their energy metabolism. These two metabolic strategies are also known as Crabtree negative and Crabtree positive respectively, and the evolution of the latter has lately been explained by the “make-accum
The paper reviews a number of cellular neural network implementations on a field-programmable gate-array. It illustrates experimentally, how these implementations can be used to measure from images or to create dynamic, autonomous processes that facilitate measurements within topographic maps. Applications range from image understanding to robot navigation
Phasor measurement signals are used as only input to a wide-area power system stabilizer to increase interarea mode damping of the Icelandic system. Modal analysis and time simulations of a detailed model show that frequency difference as PSS input gives a damping improvement that is robust to drastic changes in system topology. Field data from phasor measurement units indicate high signal quality
