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Short-chain fatty acids (SCFA) are involved in immune system and inflammatory responses. We comprehensively assessed the host genetic and gut microbial contribution to a panel of eight serum and stool SCFAs in two cohorts (TwinsUK, n = 2507; ZOE PREDICT-1, n = 328), examined their postprandial changes and explored their links with chronic and acute inflammatory responses in healthy individuals and

Objectives: Genome-wide association studies have revealed over 200 genetic susceptibility loci for prostate cancer (PCa). By combining them, polygenic risk scores (PRS) can be generated to predict risk of PCa. We summarize the published evidence and conduct meta-analyses of PRS as a predictor of PCa risk in Caucasian men. Patients and methods: Data were extracted from 59 studies, with 16 studies i

Background: Conservative management is an option for prostate cancer (PCa) patients either with the objective of delaying or even avoiding curative therapy, or to wait until palliative treatment is needed. PIONEER, funded by the European Commission Innovative Medicines Initiative, aims at improving PCa care across Europe through the application of big data analytics. Objective: To describe the cli

Primary and secondary bile acids (BAs) influence metabolism and inflammation, and the gut microbiome modulates levels of BAs. We systematically explore the host genetic, gut microbial, and habitual dietary contribution to a panel of 19 serum and 15 stool BAs in two population-based cohorts (TwinsUK, n = 2,382; ZOE PREDICT-1, n = 327) and assess changes post-bariatric surgery and after nutritional

Focusing on the photoinduced electron transfer properties of the D-D-A molecule ((TPA-TT)-BODIPY-C60) in an external electric field (Fext), the excited-state properties in which the double-donor molecule is excited to form three charge-separated states were simulated. The charge-Transfer processes of these three charge-separated states were investigated by considering the two donors as a whole ((T

Investigating the optical properties of various chemical compounds using UV-vis spectrophotometers is an essential part of education in chemistry. However, commercial spectrophotometers are usually treated as "magic black boxes", where the dominant majority of optical elements are hidden "under the hood". This often limits understanding of the mechanisms behind the generation of spectral curves, w

In order to describe a novel approach for the clinical study of metastases, we provide here age-specific incidence and survival data for cancer of unknown primary (CUP). Metastases in various organs are found at CUP diagnosis, which have implications for prognosis, and we hypothesize similar prognostic implications for metastases found at diagnosis of primary cancers. We identified 33,224 CUP pati

Microsoft Word - Läsanvisningar.docx Industri och imperier VT 2017 LÄSANVISNINGAR Föreläsning (F)/ Gruppövning (G) Rubrik Litteratur F1 Industri och imperier – en introduktion Marks, kap. 4–6; Caine & Sluga, kap. 1. F2 Industrialismen i Europa och världen McKay (10:e uppl. 2015), kap. 23; Beaudoin; Caine & Sluga, kap. 2. F3 Stater och nationer i Europa McKay, kap. 24; Caine & Sluga, kap. 3–4. G1 R

https://www.historiska.lu.se/media/utbildning/dokument/kurser/HISA16/20171/Lsanvisningar.pdf - 2026-05-26

We explore vibe coding as a rapid prototyping approach powered by generative AI. We discuss how it lowers the barrier to creating high-fidelity prototypes, enabling nontechnical users to build apps, and examine its implications for communication, validation, and iterative software design.

Background and objective: Prostate-specific membrane antigen (PSMA) positron emission tomography/computed tomography (PET/CT) is an evolving diagnostic tool for prostate cancer. There is a need to harmonise existing guidelines and reporting recommendations for PSMA PET/CT. The Standardised PSMA PET/CT Analysis and Reporting Consensus (SPARC) project aims to consolidate classifications and recommen

Background and objective: Although cardiovascular toxicity from modern systemic treatments in metastatic hormone-sensitive prostate cancer (mHSPC) remains a concern, real-world data are limited. We aimed to characterise patients treated for mHSPC across multiple large cohorts and estimate cardiovascular adverse event (AE) risks. Methods: Leveraging PIONEER's Big Data platform, with databases stand

The integration of machine learning (ML) into software operations (MLOps) has significantly increased the demand for data to train and test models, making data sharing and reuse essential to mitigate the high costs of data collection and preprocessing. This study aims to advance the understanding of data sharing within an MLOps context by examining the establishment and governance of a data ecosys

This study explores the integration of Large Language Model (LLM) and Information Retrieval (IR) components to enable filtered search over multimodal structured data. We identify core integration challenges and introduce a conceptual framework based on two paradigms: filtered retrieval and filtered re-ranking. With the focus on the latter, we employ RT-3 rank transformation to dynamically adjust t

Objective: Although previous studies have shown reduced cardiovascular events following parathyroidectomy (PTX), it is unclear whether this extends to contemporary patients diagnosed and treated with milder disease than previously. The aim of this nation-wide study was to determine the effect on cardiovascular events after PTX, and to comprehensively evaluate cardiovascular disease manifestations

Correlated electron physics is intrinsically a multiscale problem, since high-energy electronic states screen the interactions between the correlated electrons close to the Fermi level, thereby reducing the magnitude of the interaction strength and dramatically shortening its range. Thus the handling of screening is an essential ingredient in the first-principles modeling of correlated electron sy

By combining ab initio downfolding with cluster dynamical mean-field theory, we study the degree of correlations in monolayer, bilayer, and bulk breathing-mode kagome van der Waals materials Nb3(F, Cl, Br, I)8. Our new material-specific many-body model library shows that in low-temperature bulk structures the Coulomb correlation strength steadily increases from I to Br, Cl, and F, allowing us to i

BACKGROUND AND OBJECTIVE: The treatment landscape for metastatic hormone-sensitive prostate cancer (mHSPC) is evolving rapidly. Real-world data (RWD) are essential to understand actual treatment use and outcomes. This study aimed to describe treatment trajectories and clinical outcomes in a large, multicenter RWD cohort under the PIONEER project. METHODS: Eight European and US databases (2016-2020

Kallelse Sida 1 av 4 Fakultetsstyrelsen PROTOKOLL STYR 2024/1669 Datum 2024-06-12 Fakultetsstyrelsens protokoll Närvarande Ledamöter Per Persson, professor, dekan, ordförande Karin Rengefors, professor, prodekan Helena Filipsson, professor Andreas Persson, universitetslektor Peter Samuelsson, professor Philipp Birken, professor Susanna Horsefield, professor Carina Rasmussen, forskningsingenjör Lar

https://www.naturvetenskap.lu.se/internt/sites/naturvetenskap.lu.se.internt/files/2024-07/Protokoll%20Fakultetsstyrelsen%202024-06-12.pdf - 2026-05-26

Tidplan period 2025-11 - 2026-03 Senast datum Kl Datum t o m System Period Check Checklista inst/fak Information central hantering Länk 2025-11-11 Raindance 10 ⃝ Registrera/komplettera intrastatuppgifter. Åtgärda alla poster som har status Ej komplett. Guide 2025-11-25 Raindance 11 Bokföringsdag för Statsbudgetanslag – kommer med i saldolistor tidigare 2025-11-25 Raindance 11 Bokföringsdag för Pri

https://www.ekonomiwebben.lu.se/sites/ekonomiwebben.lu.se/files/2025-11/TIDPLAN-20251113.pdf - 2026-05-26