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Most research on global governance has focused either on theoretical accounts of the overall phenomenon or on empirical studies of distinct institutions that serve to solve particular governance challenges. In this article we analyze instead “governance architectures,” defined as the overarching system of public and private institutions, principles, norms, regulations, decision-making procedures a

Systemic lupus erythematosus (SLE) is a severe autoimmune connective tissue disease. Our current knowledge about the serum proteome, or serum biomarker panels, reflecting disease and disease status is still very limited. Affinity proteomics, represented by recombinant antibody arrays, is a novel, multiplex technology for high-throughput protein expression profiling of crude serum proteomes in a hi

The Cochrun-Grabel (C-G) method, an algorithm for finding the characteristic polynomial of a circuit containing reactances, has so far been restricted to circuits not employing mutual inductances. In this paper we present an intuitive, yet rigorous, proof of the Cochrun-Grabel method for a general RLC circuit, and we extend the method to allow the analysis of an RLC circuit containing mutual induc

A new type of chip based microelectrode for acute electrophysiological recordings in the CNS has been developed. It's designed to be adaptable to a multitude of specific neuronal environments, in this study the cerebellar cortex of rat and cat. Photolithographically patternened SU-8 is used to yield flexible and biocompatible penetrating shanks with gold leads. Electrodes with an impedance of abou

Harvesting the excess energy from absorbed above bandgap photons is a promising approach to overcome the detailed balance limit for higher solar cell efficiencies. However, this remains very challenging for 2D layered halide perovskites as the fast excess energy loss competes effectively with charge extraction. Herein, the authors engineer the energy cascade manifold of quantum well (QW) states in

Flicker, or more precisely temporal light modulation (TLM), has re-emerged as a problem with the introduction of LED-based lighting technology. TLM, meaning variations in light intensity over time, may have negative effects on human health, causing annoyance, headaches, eyestrain and migraine. In addition to the unnecessary suffering TLM causes in individuals, the negative consequences of TLM crea

In the wake of crises and “enlargement fatigue”, EU politics deprioritized enlargement. Recently, however, the Commission motioned a reinvigorated enlargement prospect for the Western Balkans, identifying Serbia and Montenegro as the front runners. This paper advises that in going forward, the EU should also look back at its five decades of enlargement. The article focuses on environmental protect

Over the last few decades, a critical revision of prior scholarship concerning Roman domestic space has led to the reappraisal of the traditional account of the atrium suggesting a possibility for this space to be ‘unroofed’. Accordingly, scholars have proposed to look for a convergence of impulses previously cultivated in isolation combining new theoretical frameworks, and a careful examination o

Growing preclinical and clinical evidence highlights neurosteroid pathway imbalances in Parkinson's Disease (PD) and L-DOPA-induced dyskinesias (LIDs). We recently reported that 5α-reductase (5AR) inhibitors dampen dyskinesias in parkinsonian rats; however, unraveling which specific neurosteroid mediates this effect is critical to optimize a targeted therapy. Among the 5AR-related neurosteroids, s

Allergen specific immunotherapy (AIT) is the only causal therapeutic option for allergic airway diseases including asthma and allergic rhinitis. AIT has been shown to restore the allergen immune tolerance, can modify both the early and late-onset allergen-specific airway hyperreactivity, helps to achieve disease control/remission and prevents new sensitisations. Recent real life data on long-term

När vi människor försöker röra på oss skickas elektriska impulser genom nervsystemet från hjärnan ner till de muskler som är inblandade i den tilltänkta rörelsen. Att kunna mäta sådana nervimpulser hade varit av värde för en rad tillämpningar—information hade då kunnat överföras direkt från nervsystemet utan att gå via långsamma, mekaniska gränssnitt så som tangentbord och pekskärmar. Olyckligtvis

Förekomst av farliga ämnen i byggnader medför betydande osäkerheter i projektplanering och budgetuppskattning och innebär hälso och säkerhetsrisk för de boende och för arbetstagare som är involverade i renoverings- och rivningsaktiviteter. Det är praxis inom svenska byggprojekt att avsätta ungefär 15% av budgeten för att hantera oväntade risker av farliga ämnen och oförutsedda händelser. De faktis

Background and purpose: Advances in characterizing cancer biology and the growing availability of novel targeted agents and immune therapeutics have significantly changed the prognosis of many patients with metastatic disease. Palliative radiotherapy needs to adapt to these developments. In this study, we summarize the available evidence for stereotactic body radiotherapy (SBRT) in the treatment o

The MAX IV 3 GeV linac delivers electron beams to two synchrotron rings and to a dedicated undulator system for X-ray beam delivery in the Short Pulse Facility (SPF). In addition, there are plans to use the linac as an injector for a future Soft X-ray Laser (SXL). For both SPF and SXL operations, longitudinal beam characterisation with a high temporal resolution is essential. For this purpose, a t

We consider a system of equations that model the temperature, electric potential and deformation of a thermoviscoelastic body. A typical application is a thermistor; an electrical component that can be used e.g. as a surge protector, temperature sensor or for very precise positioning. We introduce a full discretization based on standard finite elements in space and a semi-implicit Euler-type metho

Clinical research usually involves time-to-event survival analysis, in which the presence of a competing event is prevalent. It is acceptable to use the conventional Cox proportional hazard regression to model cause-specific hazard. However, this cause-specific hazard cannot directly translate to the cumulative incidence function, and the latter is usually clinically relevant. The subdistribution