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Frontotemporal dementia (FTD) is the second most common cause of early-onset dementia after Alzheimer disease (AD). Efforts in the field mainly focus on familial forms of disease (fFTDs), while studies of the genetic etiology of sporadic FTD (sFTD) have been less common. In the current work, we analyzed 4,685 sFTD cases and 15,308 controls looking for common genetic determinants for sFTD. We found
Cardioneuroablation has emerged as a potential alternative to cardiac pacing in selected cases with vasovagal reflex syncope, extrinsic vagally induced sinus bradycardia-arrest or atrioventricular block. The technique was first introduced decades ago, and its use has risen over the past decade. However, as with any intervention, proper patient selection and technique are a prerequisite for a safe
Within a collaboration between MAX-lab and BESSY a one stage seeded HGHG-FEL has been set up at Maxlab. BESSY has built the undulator system consisting of a modulator, a radiator and an electromagnetic chicane. BESSY has also installed three types of diagnostic tools: optical fibres for a fast Cherenkov beam loss detection, optical fibres for absolute dose measurements via their radiation-induced
BACKGROUND: After over a decade of developments in field collection, laboratory methods and advances in high-throughput sequencing, contamination remains a key issue in ancient DNA research. Currently, human and microbial contaminant DNA still impose challenges on cost-effective sequencing and accurate interpretation of ancient DNA data.RESULTS: Here we investigate whether human contaminating DNA
The emergence of pandemics like Covid-19 has raised important issues regarding the safe utilisation of spaces due to the potential for virus transmission in both enclosed and open built environments. This chapter explores the challenges posed by pandemics in terms of safe space utilisation, considering the potential virus transmission risks. It presents a risk analysis methodology that makes use o
The global energy landscape is entrenched in fossil fuels, shaping modern life profoundly. Germany, a prominent example, grapples with transitioning from its fossil-fuelled infrastructure despite governmental support for decarbonization. Carbon capture and storage (CCS) and hydrogen appear as crucial tools in this transition. A recent partnership between Germany and Norway seeks to leverage Norway
Echinolittorina malaccana, a marine gastropod living on rocky shores along the Indo-West Pacific coasts, shows consistent mate choice in which males prefer to mate with females slightly larger than themselves. Previous studies suggest that the strength of this preference is, to a certain extent, context dependent, being influenced by both demographic and individual (potentially genetic) factors. T
Dust storms have been an increasing concern in the Middle East. Severe drought events and human activities, particularly water and land management, have led to emerging dust sources in the last few decades. This study combines spatio-temporal maps of land susceptibility to dust storm incidence with agricultural land use change data to examine the link between farming patterns and dust storm genera
The Swedish HE Ordinance requires all supervisors of doctoral students to undergo introductory training. The content, goals, learning outcomes and duration is not specified by the Ordinance and thus practices vary between institutions. In 2009/2010, a new study program for doctoral supervisors was launched at Lund University. The program was designed to:- provide research-based support for doctora
Recent contributions to ecological economics and related social sciences indicate that issues such as climate change, resource depletion and environmental degradation cannot be effectively addressed under conditions of continued economic growth. This paper aims at empirically identifying structural potentials and policy challenges for prosperity at scaleswhere economic development remainswithin ec
Purpose This paper investigates contracts of the intermodal transport market and the incentives they create for a modal shift and thus the financial and environmental efficiency of freight transport. Design/methodology/approach The research used a mixed-methods approach where qualitative case interviews and quantitative modeling was combined. Two cases of contractual relationships between a serv
The small size of the billions of migrating songbirds commuting between temperate breeding sites and the tropics has long prevented the study of the largest part of their annual cycle outside the breeding grounds. Using light-level loggers (geolocators), we recorded the entire annual migratory cycle of the red-backed shrike Lanius collurio, a trans-equatorial Eurasian-African passerine migrant. We
The population sizes of five perennial vascular plant species confined to old unimproved dry grasslands were assessed, viz. Anthericum ramosum, Filipendula vulgaris, Silene nutans, Thymus pulegioides, and Thymus serpyllum. All populations within the region were included. Only for Filipendula vulgaris and Thymus serpyllum, significant relationships between habitat area and population size were foun
LICE (A Large Ion Collider Experiment) is studying the physics of strongly interacting matter, and in particular the properties of the Quark–Gluon Plasma (QGP), using proton–proton, proton–nucleus and nucleus–nucleus collisions at the CERN LHC (Large Hadron Collider). The ALICE Collaboration is preparing a major upgrade of the experimental apparatus, planned for installation in the second long LHC
The anticancer active complex cisplatin interacts preferentially with the common, G - C rich, wobble base pair region of both tRNA(Ala) and Mh(Ala) in a reaction that at pH 6.3 is rate limited by the acid hydrolysis of the metal complex.
Inhibitors of the enzyme dipeptidyl peptidase IV (DPP IV) are of increasing interest to both diabetologists and the pharmaceutical industry alike, as they may become established as the next member of the oral antidiabetic class of therapeutic agents, designed to lower blood glucose and, possibly, prevent the progressive impairment of glucose metabolism in patients with impaired glucose tolerance a
