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ICOS-ligand triggering impairs osteoclast differentiation and function in vitro and in vivo

Osteoblasts, osteocytes, and osteoclasts (OCs) are involved in the bone production and resorption, which are crucial in bone homeostasis. OC hyperactivation plays a role in the exaggerated bone resorption of diseases such as osteoporosis, rheumatoid arthritis, and osteolytic tumor metastases. This work stems from the finding that OCs can express B7h (ICOS-Ligand), which is the ligand of the ICOS T

Interdisciplinarity and Lifelong Learning in Doctoral Education for Sustainable Development: A Case Study on the Agenda 2030 Graduate School at Lund University

The 17 UN Sustainable Development Goals (SDGs) provide a framework for “peace and prosperity for people and the planet, now and into the future” (UN, 2015). Fast-moving societal questions as the ones related to the SDGs are often addressed from within traditional disciplinary research paradigms, which might not be best equipped for tackling the emerging challenges. At Lund University, an interdisc