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Sensations, symptoms, and then what? Early bodily experiences prior to diagnosis of lung cancer

Lung cancer (LC) generally lacks unique core symptoms or signs. However, there are a multitude of bodily sensations that are often non-specific, not easily understood, and many times initially not recognized as indicative of LC by the affected person, which often leads to late diagnosis. In this international qualitative study, we inductively analyzed retrospective accounts of 61 people diagnosed

Sociodemographic and Clinical Characteristics of Older Adults With Suicide-Related Emergency Department Presentations

Objectives: To identify characteristics of older adult emergency department (ED) patients aged ≥65 with suicidal ideation and/or behavior. Methods: A single center retrospective chart review analyzed 392 patients (≥65) with suicidal ideation and/or behavior (2013–2019). Comprehensive full-text searches were used. Subgroup analyses for age and gender were conducted. Results: Depressive disorder was

Digital services in eldercare : exploring the dualities in the domestication of welfare technologies

IntroductionThe implementation of welfare technologies in Swedish eldercare reflects ongoing sociotechnical transitions, which promise to optimise care practices and administrative processes. AimOur study explores how eldercare personnel interpret and ascribe meanings to welfare technologies in their everyday care work.Material and MethodsThe study draws on an empirical dataset comprising 181 phot

Trends in the place of death in Sweden from 2013 to 2019 – disclosing prerequisites for palliative care

Background: The drive for home care has increasingly impacted the organization and allocation of resources within the Swedish healthcare system. Objectives: With an interest in uncovering prerequisites for palliative care, this study aimed to investigate longitudinal trends in place of death within the adult Swedish population from 2013 to 2019 and examine potential associations between place of d

Identification of sentinel lymph node macrometastasis in breast cancer by deep learning based on clinicopathological characteristics

The axillary lymph node status remains an important prognostic factor in breast cancer, and nodal staging using sentinel lymph node biopsy (SLNB) is routine. Randomized clinical trials provide evidence supporting de-escalation of axillary surgery and omission of SLNB in patients at low risk. However, identifying sentinel lymph node macrometastases (macro-SLNMs) is crucial for planning treatment ta

Symmetry of loop extrusion by dimeric SMC complexes is DNA-tension-dependent

Structural maintenance of chromosome (SMC) complexes organize and regulate genomes via DNA loop extrusion. During this process, the complexes increase the loop size by reeling in DNA from one or both sides of the loop. The factors governing this symmetry remain unclear. Here, we combine single-molecule analysis and molecular dynamic simulations to investigate the symmetry of loop extrusion of vari

Variable impedance skill learning for contact-rich manipulation

Contact-rich manipulation tasks remain a hard problem in robotics that requires interaction with unstructured environments. Reinforcement Learning (RL) is one potential solution to such problems, as it has been successfully demonstrated on complex continuous control tasks. Nevertheless, current state-of-the-art methods require policy training in simulation to prevent undesired behavior and later d

Volcanic temperature changes modulated volatile release and climate fluctuations at the end-Triassic mass extinction

Emplacement of the Central Atlantic Magmatic Province (CAMP) is thought to have triggered global environmental changes and the end-Triassic mass extinction (ETE). However, the mechanisms linking volcanism and environmental change are unclear. Here we provide new insight into these linkages by measuring the abundance of both sedimentary five- to six-ring polycyclic aromatic hydrocarbons (PAHs) and

Exceptional points in anisotropic photonic structures : From non-Hermitian physics to possible device applications

We demonstrate that exceptional points exist in fully transparent, optically "effectively" biaxial, anisotropic micro-cavities, fabricated using an uniaxial cavity material with its axis inclined to the Bragg mirror growth direction. This is similar to the existence of singular (optic) axes in absorbing biaxial crystals, but the lack of time reversal symmetry is mediated by the mode broadening, i.

No apparent increase in treatment uptake for gambling disorder during ten months of the covid-19 pandemic—analysis of a regional specialized treatment unit in Sweden

The COVID-19 pandemic and its impact on society has been suspected to affect gambling behaviors. Potentially, the pandemic crisis may result in increased problem gambling, for example, due to COVID-19-related psychological distress, unemployment, and financial difficulties. In ad-dition, the cancellation of sports in early parts of the crisis has been suspected to alter gambling behaviors. Policy

The Swedish Environmental Classification and Information System for Pharmaceuticals - An empirical investigation of the motivations, intentions and expectations underlying its development and implementation

In 2005 the Swedish Association of the Pharmaceutical Industry (LIF) initiated a national environmental classification and information system for pharmaceuticals. This investigation reports the results from a survey, conducted among the persons involved in the start-up process. The aim of this study is to generate knowledge contributing to the clarification of the motivations, expectations, and in

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For model verification which is mainly focused on the control of discretization errors of numerical results, a posteriori error estimation plays an important role in various numerical tools such as the finite element method. The outputs of interest are usually converted into integral functionals over the problem domain for a posteriori error analysis. Among the available techniques for goal-orient

Dual-binary phase gratings for x-ray interferometry

X-ray phase-contrast imaging by grating interferometry has in the past decades been established both at synchrotron radiation sources and at conventional x-ray tubes. Due to the sensitivity to x-ray phase shifting, contrast in soft tissue has been improved significantly and the possibilities to do virtual histology of tissue biopsies are being pioneered. Constraints in the design of a grating inte

Social Injustice, Group Membership and Epistemic Trust in Robots

This paper focuses on the intersection of social dynamics, knowledge production, and the implementation of identity features in robotic platforms. Concentrating on the concept of epistemic injustice, particularly in the context of trust, the study highlights the potential for justified distrust based on experienced injustice. The incorporation of social identity features, such as gender, signals g

Degradation of the microbicide 2-(thiocyanomethylthio) benzothiazole by direct photolysis

Microbicides in the leather industries are employed to avoid the biodeterioration of the hides by microorganisms. This problem may lead to harmful characteristics to the end product such as stains, roughness and decrease mechanical properties of leather. Therefore, microbicides like the 2-(thiocyanomethylthio) benzothiazole (TMCTB) are applied in distinct steps of the tanning process as alternativ

Introduction to a Research Agenda for Sustainable Cities and Communities

How can cities and communities around the world become more sustainable? What can we do as researchers to help them? As we move through the twenty-first century, these questions assume ever-greater importance. Many of the quickest wins for human and planetary health involve reimagining and reconfiguring cities. Activities that generate negative impacts like air pollution and poor health are concen