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Reply to letter by Deng et al. "Could the levels of inflammation biomarkers predict OA? : Comment on the article by Roemer FW et al."
As explained in the methods-section, we chose to analyze the 2-year data in regard to inflammatory activity based on MRI and synovial biomarkers (and not earlier time points) as our aim was to capture patients that experienced "prolonged" or chronic inflammation, which may be regarded as a potential risk factor for osteoarthritis (OA) development. Virtually all patients of an acute injury cohort (
Fresh and Aged Organic Aerosol Emissions from Renewable Diesel-Like Fuels HVO and RME in a Heavy-Duty Compression Ignition Engine
A modern diesel engine is a reliable and efficient mean of producing power. A way to reduce harmful exhaust and greenhouse gas (GHG) emissions and secure the sources of energy is to develop technology for an efficient diesel engine operation independent of fossil fuels. Renewable diesel fuels are compatible with diesel engines without any major modifications. Rapeseed oil methyl esters (RME) and o
Fluorescently Guided Optical Photothermal Infrared Microspectroscopy for Protein-Specific Bioimaging at Subcellular Level
Infrared spectroscopic imaging is widely used for the visualization of biomolecule structures, and techniques such as optical photothermal infrared (OPTIR) microspectroscopy can achieve <500 nm spatial resolution. However, these approaches lack specificity for particular cell types and cell components and thus cannot be used as a stand-alone technique to assess their properties. Here, we have deve
Sox5 regulates beta-cell phenotype and is reduced in type 2 diabetes
Type 2 diabetes (T2D) is characterized by insulin resistance and impaired insulin secretion, but the mechanisms underlying insulin secretion failure are not completely understood. Here, we show that a set of co-expressed genes, which is enriched for genes with islet-selective open chromatin, is associated with T2D. These genes are perturbed in T2D and have a similar expression pattern to that of d
Targeting Toll-like receptor-driven systemic inflammation by engineering an innate structural fold into drugs
There is a clinical need for conceptually new treatments that target the excessive activation of inflammatory pathways during systemic infection. Thrombin-derived C-terminal peptides (TCPs) are endogenous anti-infective immunomodulators interfering with CD14-mediated TLR-dependent immune responses. Here we describe the development of a peptide-based compound for systemic use, sHVF18, expressing th
Galectin-3 shapes toxic alpha-synuclein strains in Parkinson’s disease
Parkinson’s Disease (PD) is a neurodegenerative and progressive disorder characterised by intracytoplasmic inclusions called Lewy bodies (LB) and degeneration of dopaminergic neurons in the substantia nigra (SN). Aggregated α-synuclein (αSYN) is known to be the main component of the LB. It has also been reported to interact with several proteins and organelles. Galectin-3 (GAL3) is known to have a
Molecular and Structural Biomarkers of Inflammation at Two Years After Acute Anterior Cruciate Ligament Injury Do Not Predict Structural Knee Osteoarthritis at Five Years
Objective: To determine the role of inflammatory biomarkers at 2 years post–anterior cruciate ligament (ACL) injury to predict radiographic knee osteoarthritis (OA) and magnetic resonance imaging (MRI)–defined knee OA at 5 years postinjury, with a secondary aim of estimating the concordance of inflammatory biomarkers assessed by MRI and synovial fluid (SF) analysis. Methods: We studied 113 patient
IL1RAP antibodies block IL-1-induced expansion of candidate CML stem cells and mediate cell killing in xenograft models
Chronic myeloid leukemia (CML) is currently treated with tyrosine kinase inhibitors, but these do not effectively eliminate the CML stem cells. As a consequence, CML stem cells persist and cause relapse in most patients upon drug discontinuation. Furthermore, no effective therapy exists for the advanced stages of the disease. Interleukin-1 receptor accessory protein (IL1RAP; IL1R3) is a coreceptor
The metabolic signature of salt intake : a cross-sectional analysis from the SCAPIS-study
Background: Untargeted metabolomic analysis provides novel insights into the relationship between sodium intake and cardiometabolic risk. This study examined cross-sectional associations between estimated sodium intake and plasma metabolite profiles in a large Swedish cohort. Methods: This cross-sectional analysis was conducted in the in the SCAPIS cohort (mean age 50–64 years, n = 8,957). Sodium
Hepatic Leukemia Factor Maintains Quiescence of Hematopoietic Stem Cells and Protects the Stem Cell Pool during Regeneration
The transcription factor hepatic leukemia factor (HLF) is strongly expressed in hematopoietic stem cells (HSCs) and is thought to influence both HSC self-renewal and leukemogenesis. However, the physiological role of HLF in hematopoiesis and HSC function is unclear. Here, we report that mice lacking Hlf are viable with essentially normal hematopoietic parameters, including an intact HSC pool durin
Baseline pain medication is associated with longer duration of high adherence in a three-month digital treatment program for hip and knee osteoarthritis
Objective: To investigate whether baseline use of pain medication is associated with program adherence during a three-month digital treatment program for individuals with hip or knee osteoarthritis (OA). Design: An observational cohort study using registry data on weekly participant adherence from 33078 participants enrolled in a digital education and exercise therapy program. Poor adherence was d
Genetic Susceptibility to Diabetes Subtypes and Risk of Developing Coronary Artery Disease
OBJECTIVE: Diabetes significantly increases the risk for atherosclerotic complications, including coronary artery disease (CAD). Previous studies have suggested that adult-onset diabetes can be classified into five different clinical subtypes, including moderate obesity-related diabetes (MOD). The aim of this study was to investigate the genetic associations between the five diabetes subtypes and
Neutralizing autoantibodies against interferon alpha in systemic lupus erythematosus : Prevalence, age of onset, and clinical associations
Objective Type I interferons (IFN) drive systemic lupus erythematosus (SLE) pathogenesis. Some patients develop neutralizing IFN autoantibodies (anti-IFN ab), which theoretically could modify disease activity. We aimed to determine the prevalence of anti-IFN ab in patients with SLE, identify the age and when during the disease course of anti-IFN ab emerge, and assess their association with organ d
Wild-Type Scandinavian Planarian-Derived Extracellular Vesicles Accelerate Skin Wound Healing in Burn and Mechanical Injuries
Skin wounds remain a clinical challenge, especially for burns and chronic wounds, and existing therapies seldom re-engage the rapid, scar-sparing repair programs observed in nature. Planarians are super-regenerators capable of rebuilding the entire organism from small fragments, and their extracellular vesicles might encode potent prorepair cues. But whether planarian-derived extracellular vesicle
Luvre-053nilssonomlaggninglosan
Test "Title" ORNIS SCANDINAVICA 14: 48-50. Copenhagen 1983 Laying of replacement clutches in the Willow Warbler Phylloscopus trochilus in Lapland, Sweden Lars Nilsson Nilsson, L. 1983. Laying of replacement clutches in the Willow Warbler Phylloscopus trochilus in Lapland, Sweden. - Ornis Scand. 14: 48-50. Clutch size and the number of young, 8 d old, were determined for 23 individually ringed fema
https://www.luvre.lu.se/sites/luvre.lu.se/files/luvre-053nilssonomlaggninglosan.pdf - 2026-05-08
CV2026 Hofvander Trulsson 10April
Sid 1 CURRICULUM VITAE E-mail: ylva.hofvander_trulsson@design.lth.se PRESENT POSITION Professor in Artistic Didactics (PhD+ Docent) June 2025 at LTH/ Lund University Head of Division- Industrial Design, Department of Design Sciences, Lund University https://www.design.lth.se/english/ Responability of research education at ID (PhD) Responability of Soft-tools workshop at Department of Design Scienc
Yearbookii 2013
M a l M ö a r t — a c a d e M y —y e a r b o o k 2 2 0 1 2 —2 0 1 3 Master of Fine arts 1 bachelor of Fine arts 2 bachelor of Fine arts 1 http://www.khm.lu.se/%3Fq%3Den/frontnews Namn / Bachelor of Fine Arts 1 2 Master oF Fine arts 1 Jóhan Martin christiansen Marten damgaard Helene Garberg kaare Golles erlend Grytbakk Wold niilas Helander ingvild Hovland kaldal ihra lill scharning Marika Markström
https://www.khm.lu.se/sites/khm.lu.se/files/yearbookii_2013.pdf - 2026-05-08
Link-manual 2015-09-23
LINK Användarmanual Lunds universitet Externa relationer September 2015 2 Innehåll Introduktion – vad är LINK? ........................................................................................................................ 6 Alumnrelationer ........................................................................................................................................... 6 Kort om
https://www.medarbetarwebben.lu.se/sites/medarbetarwebben.lu.se/files/link-manual_2015-09-23.pdf - 2026-05-08
Behavioral Terminal Node inftrastructure Report 2021
Microsoft Word - Behavioral Terminal node_inftrastructure report 2021.docx Multipark infrastructure report form 2021 In vivo- terminal node Cecilia Lundberg 1. Short description of the infrastructure. The terminal room contains two set ups for perfusion of rodents and instruments for fresh dissection of brains. Furthermore, there are facilities to prepare solutions and weigh drugs as well as store
