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Genetic and In Vitro Inhibition of PCSK9 and Calcific Aortic Valve Stenosis

The authors investigated whether PCSK9 inhibition could represent a therapeutic strategy in calcific aortic valve stenosis (CAVS). A meta-analysis of 10 studies was performed to determine the impact of the PCSK9 R46L variant on CAVS, and the authors found that CAVS was less prevalent in carriers of this variant (odds ratio: 0.80 [95% confidence interval: 0.70 to 0.91]; p = 0.0011) compared with no

Diabetes mellitus as a risk factor for compression neuropathy: a longitudinal cohort study from southern Sweden

Introduction Compression neuropathies (CN) in the upper extremity, the most common being carpal tunnel syndrome (CTS) and ulnar nerve entrapment (UNE), are frequent among patients with diabetes mellitus (DM). Earlier studies have shown contradicting results regarding DM as a risk factor for CN. Thus, the aim of the present population-based, longitudinal study was to explore potential associations

Association of Circulating Monocyte Chemoattractant Protein-1 Levels with Cardiovascular Mortality : A Meta-analysis of Population-Based Studies

Importance: Human genetics and studies in experimental models support a key role of monocyte-chemoattractant protein-1 (MCP-1) in atherosclerosis. Yet, the associations of circulating MCP-1 levels with risk of coronary heart disease and cardiovascular death in the general population remain largely unexplored. Objective: To explore whether circulating levels of MCP-1 are associated with risk of inc

Genetic analysis of dasatinib-treated chronic myeloid leukemia rapidly developing into acute myeloid leukemia with monosomy 7 in Philadelphia-negative cells.

Despite the recent success of tyrosine kinase inhibitors (TKIs) in the treatment of chronic myeloid leukemia (CML), approximately 2-17% of patients develop clonal cytogenetic changes in the Philadelphia-negative (Ph(-)) cell population. A fraction of these patients, in particular those displaying trisomy 8 or monosomy 7, are at risk of developing a myelodysplastic syndrome (MDS) or acute myeloid l

N-Terminal Prosomatostatin and Risk of Vascular Dementia

BACKGROUND: Increased somatostatin plasma concentration has been found in patients with vascular dementia. However, it is unknown whether or not somatostatin levels may predict dementia development in the general population. To this end, we sought to assess the association of circulating N-terminal prosomatostatin (NT-proSST) with incident dementia among community-dwelling older adults.METHODS: In

Alcohol consumption and risk of urothelial cell bladder cancer in the European prospective investigation into cancer and nutrition cohort

Findings on the association between alcohol consumption and bladder cancer are inconsistent. We investigated that association in the European Prospective Investigation into Cancer and Nutrition cohort. We included 476,160 individuals mostly aged 35–70 years, enrolled in ten countries and followed for 13.9 years on average. Hazard ratios (HR) for developing urothelial cell carcinoma (UCC; 1,802 inc

Claudin-4 expression is associated with progression free survival in ovarian cancer, but not with chemotherapy response

The tight junction protein claudin-4 has been reported to be overexpressed in advanced ovarian cancer. We investigated the prognostic significance of claudin-4 overexpression and whether claudin-4 expression could predict platinum response in primary ovarian carcinoma (OC). Claudin-4 expression was evaluated by immunohistochemistry in a tissue microarray of 140 OCs. Multivariable Cox-regression mo

Genetic variation in the ADIPOQ gene, adiponectin concentrations and risk of colorectal cancer : a Mendelian Randomization analysis using data from three large cohort studies

Higher levels of circulating adiponectin have been related to lower risk of colorectal cancer in several prospective cohort studies, but it remains unclear whether this association may be causal. We aimed to improve causal inference in a Mendelian Randomization meta-analysis using nested case–control studies of the European Prospective Investigation into Cancer and Nutrition (EPIC, 623 cases, 623

Inlamning av arkeologiskt material till lunds universitets historiska museum

Inlämning av arkeologiskt material till Historiska museet vid Lunds universitet (LUHM) Inlämning Fyndmaterialet lämnas in efter det att beslut om fyndfördelning tagits av Riksantikvarieämbetet. LUHM tar bara emot konserverade föremål, om inte annan överenskommelse gjorts med museets uppdragskonservering. Hela fyndmaterialet lämnas in vid samma tillfälle till magasinsansvarig. Konserverade mynt läm

https://www.historiskamuseet.lu.se/sites/historiskamuseet.lu.se/files/inlamning_av_arkeologiskt_material_till_lunds_universitets_historiska_museum.pdf - 2026-06-01

Tamfor demgne honorie

LUNDS UNIVERSITET LUND UNIVERSITY INTERNATIONAL MASTER' S PROGRAMME IN ENVIRONMENTALSCIENCE SUSTAINABLE PLAN TO ROLL BACK MALARIA IN CAMEROON VIA EDUCATION, USE OF INSECTICIDES IMPREGNATED BEDNETS AND ENVIRONMENT AL SANITATION MASTER'S THESIS BY DEMGNE HONORlE ETS TAMFORFIDELIS P.O BOX 60 BAMENDA; N.W PROVINCE CAMEROON E-MAIL ADDRESSES: HONORIE.DEMGNE.608(a?STUDENT.LUSE HTDEMGNE@HOTMAIL.COM / SUPE

https://www.lumes.lu.se/sites/lumes.lu.se/files/tamfor_demgne_honorie.pdf - 2026-06-01

Cpf

CFP Inbjudan till bidrag Målgrupp för denna konferens är ALLA med pedagogiska uppdrag – lärare, forskarhandledare, studievägledare, studierektorer, utbildningsadministratörer, utbildningsledare, osv. Konferensen skapar en organiserad möjlighet för lärare och andra inom universitetet att dela kunskap och erfarenheter av pedagogiska utvecklingsfrågor på samtliga nivåer – från grundnivå till forskarn

https://www.medarbetarwebben.lu.se/sites/medarbetarwebben.lu.se/files/cpf.pdf - 2026-06-01

Strategisk plan 2017-2026

PowerPoint-presentation Strategisk plan Lunds universitet 2017–2026 Ett universitet i världsklass som förstår, förklarar och förbättrar vår värld och människors villkor Visionen. I presentationsläge länkar Youtubeikonen till en kort film om strategiska planen. Prioriterade områden 2017–2026 Utbildning och forskning ska vara sammanflätade Aktiva samarbeten stimuleras för att lösa samhällsutmaningar

https://www.medarbetarwebben.lu.se/sites/medarbetarwebben.lu.se/files/strategisk_plan_2017-2026.pptx - 2026-06-01

Msfm31 medicinsk stralningsfysik - klinisk praktik och lagstiftning 2016-02-10

HT2014 – VT2015 Kursanalys MSFM31 Medicinsk strålningsfysik – klinisk praktik och lagstiftning Lena Jönsson Beskrivning av delkursen Kursen består av fyra praktikperioder under vardera tre veckor. Tidigare har studenterna gjort hela sin praktik antingen i Lund eller i Malmö. Från och med hösten 2012 har studenterna fått studenterna fått delta i verksamheterna i både Lund och Malmö samt även göra k

https://www.msf.lu.se/sites/msf.lu.se/files/msfm31_medicinsk_stralningsfysik_-_klinisk_praktik_och_lagstiftning_2016-02-10.pdf - 2026-06-01

Optimizing probes for multi-beam ptychography

Multi-beam ptychography (MBP) offers a scalable solution to improve the throughput of state-of-the-art ptychography by increasing the number of coherent beams that illuminate the sample simultaneously. However, increasing the number of beams in ptychography makes ptychographical reconstructions more challenging and less robust. It has been demonstrated that MBP reconstructions can be made more rob

Oral fluoroquinolone use and the risk of aortic and mitral valve regurgitation : a nationwide cohort study

Objective This study aims to investigate whether oral fluoroquinolone use is associated with an increased risk of aortic and mitral valve regurgitation. Design A nationwide cohort study based on linked healthcare register data encompassing patient characteristics, prescription data and cases of aortic and mitral valve regurgitation. Setting Sweden, 2006–2018. Participants Study participants were a

Loss of SETDB1-mediated H3K9me3 in human neural progenitor cells leads to transcriptional activation of L1 retrotransposons

Heterochromatin is characterized by an inaccessibility to the transcriptional machinery and is associated with the histone mark H3K9me3. However, studying the functional consequences of heterochromatin loss in human cells has been challenging. Here, we used CRISPRi-mediated silencing of the histone methyltransferase SETDB1 to remove H3K9me3 heterochromatin in human neural progenitor cells. Despite

180507 instruktion studerandeskyddsombud lu2 0

Microsoft Word - 180507 Instruktion studerandeskyddsombud LU.docx Instruktion för studerandeskyddsombud vid Lunds universitet Allmänt Studerandeskyddsombud företräder studenterna i arbetsmiljöfrågor. Ombuden utses av studenterna, valprocesserna för detta sköts av respektive kår och Lunds Universitets Studentkårer (LUS). Kårerna ansvarar också för att valda studerandeskyddsombud vet vilket/vilka st

https://www.konstnarliga.lu.se/sites/konstnarliga.lu.se/files/180507_instruktion_studerandeskyddsombud_lu2_0.pdf - 2026-06-01

Annotation and characterization of lesions in breast tomosynthesis images

Rapid adoption of artificial intelligence methods in breast imaging research emphasizes the need for large, appropriately curated image databases for development and validation. For digital breast tomosynthesis (DBT), there are few public databases with only limited lesion annotation. Recently, we have developed Malmö Breast ImaginG (M-BIG), a large database of 104 791 women screened at Skåne Univ