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Trends in adult body-mass index in 200 countries from 1975 to 2014 : A pooled analysis of 1698 population-based measurement studies with 19.2 million participants

Background Underweight and severe and morbid obesity are associated with highly elevated risks of adverse health outcomes. We estimated trends in mean body-mass index (BMI), which characterises its population distribution, and in the prevalences of a complete set of BMI categories for adults in all countries. Methods We analysed, with use of a consistent protocol, population-based studies that ha

Low-frequency noise in ferroelectric III-V vertical gate-all-around FETs

In this letter, we demonstrate low-frequency noise (LFN) characterization of an InAs vertical gate-all-around hafnium-zirconium oxide (HZO) ferroelectric field-effect transistor (FeFET). The LFN characteristics are investigated before and after ferroelectric switching for up to 1000 cycles in the FeFET. The evolution of such cycling reveals distinct differences in the LFN for the two polarization

Acoustophoresis in tumor cell enrichment

This chapter outlines the opportunities and current developments of label-free separation of circulating tumor cell (CTC) from blood cells using acoustophoresis. It describes two platforms that have been developed to enable subsequent evaluation of acoustophoresis in clinical settings. All nucleated cells in suspension flow along a microchannel wherein the cells are exposed to an acoustic field. T

A comprehensive characterisation of natural aerosol sources in the high Arctic during the onset of sea ice melt

The interactions between aerosols and clouds are still one of the largest sources of uncertainty in quantifying anthropogenic radiative forcing. To reduce this uncertainty, we must first determine the baseline natural aerosol loading for different environments. In the pristine and hardly accessible polar regions, the exact nature of local aerosol sources remains poorly understood. It is unclear ho

Measuring cohesive law of wood adhesive bonds for engineering of timber joints and products

Accurate prediction of crack growth and strength in glued timber joints and components can be achieved by using cohesive laws in constitutive models. These laws represent the traction-separation relationship that measures the stress transmitted between crack faces in a cohesive zone, and can be obtained directly from experiments. However, studies on measuring the cohesive laws of wood adhesive bon

Invisible Higgs decay from dark matter freeze-in at stronger coupling

We study the Higgs boson decay into dark matter (DM) in the framework of freeze-in at stronger coupling. Even though the Higgs-DM coupling is significant, up to order one, DM does not thermalize due to the Boltzmann suppression of its production at low temperatures. We find that this mechanism leads to observable Higgs decay into invisible final states with the branching fraction of 10% and below,

Impact of Layout on the RF Performance of Vertical In–Ga–As Nanowire MOSFETs

High-speed vertical In–Ga–As nanowire MOS field-effect transistor (MOSFET) measurements were analyzed through parametric layout models. Measurements from small and large transistors were used to fit dependencies on the number of gate fingers and the number of wires per finger. Extrapolations via intrinsic and parasitic elements reveal the optimal layout for peak frequency performance. To achieve a

Exploring the interaction between ambient air pollution and road traffic noise on stroke incidence in ten Nordic cohorts

Introduction: Ambient air pollution and road traffic noise are stroke risk factors, but evidence on their potential joint effects remains limited. This study investigated the independent and joint associations of air pollution and road traffic noise on stroke incidence using both multiplicative and additive scales. Methods: We followed stroke incidence in ten cohorts in Sweden, Denmark, and Finlan

Decolonizing education in development practice : Experiences and challenges from India, Nigeria, Sweden, and the US

Decolonizing development has animated conferences, grants, and programs for several years, a response to the ineffectiveness of much aid and ongoing colonial legacies. Yet, little attention has gone to the education of development practitioners and its impacts on their professional practices. We lack practical approaches for decolonizing our classrooms, especially approaches based on experiences o

Simulating mismatch between calibration and target population in AI for mammography the retrospective VAIB study

AI cancer detection models require calibration to attain the desired balance between cancer detection rate (CDR) and false positive rate. In this study, we simulate the impact of six types of mismatches between the calibration population and the clinical target population, by creating purposefully non-representative datasets to calibrate AI for clinical settings. Mismatching the acquisition year b

Drug exposure and subsequent diagnosis with ANCA-associated vasculitis – A population-based case- control study

Objective: To determine if prior exposure to certain drugs is associated with increased risk of ANCA associated vasculitis(AAV).Patients and Method: We performed a population-based case–control study including patients with AAV diagnosed between2006 and 2019 from a defined geographic area in southern Sweden. For each case, we identified 10 controls randomly sampledfrom the background general popul

The Impact of Senescent Cells on Limb Regeneration

Cellular senescence is a state in which cells enter cell cycle arrest. However, senescent cells have the ability to secrete signaling molecules such as chemokines, cytokines, and growth factors. This secretory activity is an important feature of senescent cells, since the secreted factors impact the surrounding cellular microenvironment. Indeed, senescent cells and their secretome play a crucial r

Associations between physical activity and ankle-brachial index : the Swedish CArdioPulmonary bioImage Study (SCAPIS)

Background: The ankle–brachial index (ABI) is the ratio of the ankle and brachial systolic blood pressures. In the clinical setting, low ABI (< 0.9) is an indicator of peripheral atherosclerosis, while high ABI (> 1.4) is a sign of arterial stiffness and calcification. The purpose of the current study was to investigate the association between ABI and physical activity levels, measured by accelero

Data-driven subclassification of ANCA-associated vasculitis : model-based clustering of a federated international cohort

Background: Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis is a heterogenous autoimmune disease. While traditionally stratified into two conditions, granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA), the subclassification of ANCA-associated vasculitis is subject to continued debate. Here we aim to identify phenotypically distinct subgroups and develop a da

Influence of AFIR's charging station spacing requirement on heavy-duty vehicle electrification rate

Den snabba utvecklingen av elektrifiering av vägtransporter i Sverige kräver forskningsbaserade beslut om placeringen av laddinfrastruktur. Europeiska unionens (EU) nya förordning för infrastruktur för alternativa bränslen (AFIR) specificerar det maximala tillåtna avståndet mellan offentliga snabbladdningsstationer (FCS) för tunga lastbilar längs det transeuropeiska transportnätverket (TEN-T). EffThe rapid progression of the electrification of road transport in Sweden requires effective research based decisions on the location of charging infrastructure. The new European Union (EU) regulation for alternative fuel infrastructure (AFIR) specifies the maximum allowed distance between public fast-charging stations (FCSs) for heavy-duty trucks along the Trans-European Transport Network (TEN-T).

Blood Pressure Regulation in Post–COVID POTS : Beyond Sinus Tachycardia

BACKGROUND:Postural orthostatic tachycardia syndrome (POTS) is a frequently diagnosed cardiovascular disorder after COVID-19 infection. POTS is characterized by the presence of excessive sinus tachycardia on standing without a fall in blood pressure (BP). We investigated the BP profile using 24-hour ambulatory BP monitoring in patients with new-onset POTS after COVID-19 compared with prepandemic p

Acoustic Trapping of Extracellular Vesicles

Extracellular vesicles (EVs) are membrane enclosed biological nanoparticles released by cells. In the past two decades, EVs have gained a lot of attention due to their role in numerous biological processes. However, their small nature complicates isolating them from biological fluids with cumbersome techniques, such as ultracentrifugation. Acoustic trapping is a technique that uses ultrasonic stan