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The presence of conventional dendritic cells type 1 (cDC1) in the tumor correlates with positive treatment outcome. The ability to cross-present neoantigens and prime protective CD8+ T-cell responses, makes cDC1s central for tumor immunity. However, in tumors cDC1 are rare and often functionally impaired. Our group reported that overexpression of the transcription factors PU.1, IRF8 and BATF3 (PIB
The chemical composition of non-refractory submicron aerosol (NR-PM1) was characterized at the Villum Research Station (Villum) at Station Nord in North Greenland during spring-summer 2016 using a Time of Flight Aerosol Chemical Speciation Monitor (ToF-ACSM). The composition is dominated by sulfate (48%) and organic species (40%). Positive Matrix Factorization (PMF) identified three key factors co
Estimated glomerular filtration rate (eGFR) reflects kidney function. Progressive eGFR-decline can lead to kidney failure, necessitating dialysis or transplantation. Hundreds of loci from genome-wide association studies (GWAS) for eGFR help explain population cross section variability. Since the contribution of these or other loci to eGFR-decline remains largely unknown, we derived GWAS for annual
Nickel (Ni)-promoted Molybdenum (Mo)-based catalysts are used for hydrotreatment processes in the chemical industry where the catalysts are exposed to high-pressure H2 at elevated temperature. In this environment, the catalyst transforms into the active phase, which involves the reduction of the oxide. Here, we report on the first in situ study on the reduction of alumina supported Ni- and Mo-base
The present disclosure relates to compositions for reprogramming cells into conventional dendritic cells (cDC), particularly into cDC type 2 (hereinafter referred to as “cDC2” or “CD11b-positive dendritic cells”), methods and uses thereof. The present disclosure relates to the development of methods for making conventional dendritic cells with antigen presenting capacity from differentiated, multi
The present disclosure relates to compositions, constructs and vectors for reprogramming cells into plasmacytoid dendritic cells or interferon type I-producing cells, methods and uses thereof. The present disclosure relates to the development of methods for making plasmacytoid dendritic cells or interferon type I-producing cells that promote antiviral and anti-tumoral immune responses from differe
Air pollution and exposure to fine airborne particles with aerodynamic diameter <2.5 μm (PM2.5) negatively impacts human health. Airways constitute a primary route of exposure but PM2.5-contaminated food, drinks as well as mucociliary and hepatobiliary clearance all constitute potential entry points into the intestine. This study evaluated intestinal histopathological and inflammatory changes as w
Few germline mutations are known to affect lung cancer risk. We performed analyses of rare variants from 39,146 individuals of European ancestry and investigated gene expression levels in 7,773 samples. We find a large-effect association with an ATM L2307F (rs56009889) mutation in adenocarcinoma for discovery (adjusted Odds Ratio = 8.82, P = 1.18 × 10−15) and replication (adjusted OR = 2.93, P = 2
Background/Purpose: To investigate the incidence rate and seasonal variation of biopsy-proven giant cell arteritis (GCA) in a well-defined population in southern Sweden. Methods: The study area was the County of Skåne with a total population of 1,324,565 as of December 2016 (37% aged ≥50 years). Patients who underwent temporal artery biopsy (TAB) between 1997 and 2016 and lived in Skåne at time o
Civilkurage är ett flitigt debatterat område i Sverige, och trots att de flesta av våra grannländer har lagstiftning om en allmän handlingsplikt att bistå en nödställd person har Sverige valt att inte införa en sådan. Syftet med uppsatsen har varit att belysa de olika problem som lagstiftaren ställs inför vid ett eventuellt införande av en civilkuragelag. Uppsatsen redogör för hur gällande rätt ärMoral courage is frequently debated in Sweden, and despite the fact that several countries in our proximity have implemented a general legal duty to rescue a person in distress, Sweden has chosen not to implement such a legislation. The main purpose of this essay is to illustrate the different problems the legislator is facing regarding the possible insertion of a “moral courage law”. The essay ac
Vägar slits konstant och kräver konstant förbättringar och ombyggnationer. För att möjliggöra detta krävs personer som befinner sig ute på vägarna. Tekniken har gått framåt inom området trafiksäkerhet men skulle behöva förbättras ytterligare om vägarbetare ska vara säkra på sin arbetsplats. Även trafiken har förändrats över åren. Idag finns fler fordon på vägarna än aldrig förr. Bilarna är säkrareRoads are constantly worn down and demands improvements and reconstructions. To make this possible there has to be road workers on the road. Road safety has been improved along the years but can still be improved more. Today there are more vehicles on the road than ever before. The cars are more safe and therefore is encouraging to higher speeds as they are driven together with all safety features
Det förekommer kommersiella standardavtal och konsumentstandardavtal. Införlivandet av standardvillkor saknar lagstiftning i både hänseenden. Högsta domstolens avgöranden är därför den primära rättskällan för utvecklingen. Konsumentavtal omfattas däremot av tvingande lagstiftning som har till syfte att skydda konsumenter från oskäliga avtalsvillkor. Standardavtalsrätten är central utgångspunkt förThere are commercial standard contracts and consumer standard agreements. The incorporation of standard terms lacks legislation in both respects. The ruling of the Supreme Court is therefore the primary source of law for development. Consumer contracts, on the other hand, are covered by mandatory legislation whose purpose is to protect consumers from unfair contract terms. The standard contract la
Mänskliga attityder är fundamentala för att bevara jordens ekosystem. Denna studie undersökte sambandet mellan mänsklig empati och upplevelsen av samhörighet med naturen, mer specifikt, med specifika växter. Undersökningen baserades på enkäter och den statistiska analysen gjordes med rmANOVA. Deltagarna (N = 106, medelålder =32,7 SD =16,0) bedömde sin empati och upplevelse av samhörighet med naturHuman attitudes toward nature are fundamental for preserving earth’s ecosystems. This study investigated the malleability of human empathy and connectedness to specific plants. We randomly assigned participants (N = 106, Mean age = 32.7, SD = 16.0) to one of three different induction conditions, and measured trait general empathy and connectedness to nature, as well as state empathy and connectedn
In Swedish, adverbials mainly occur in two positions in the clause: postverbally (last in the clause) or medially (before the finite verb in subordinate clauses and after the finite verb but before e.g. infinite verbs in main clauses). VP adverbials are said to have their natural position postverbally, but they can also be placed medially. This thesis examines factors that influence the placement
Sustainability reporting has become the primary measure of corporate sustainability in the EU, with increasing awareness among companies about the importance of disclosing sustainability matters. Concurrently, the European Union has enacted several pieces of legislation regarding sustainability reporting, notably the Corporate Sustainability Reporting Directive. While blockchain technology initial
Syftet med denna uppsats är att undersöka hur Europeiska Unionens (EU) lagstiftning avseende saluföring av utsäde av köksväxter påverkar mångfalden av växtgenetiska resurser samt att utreda potentiella förbättringsförslag till den nuvarande lagstiftningen. EU:s utsädeslagstiftning består främst av direktiv 2002/55 som anger att enbart certifierat utsäde från registrerade sorter får saluföras i EU The main purpose of this essay is to investigate how the European Union’s (EU) vegetable seed marketing legislation affects the diversity of plant genetic resources and to examine possible improvement to further this diversity. The EU seed legislation consists of directive 2002/551 which provides that only certified seeds from registered varieties may be sold in the EU, and of directive 2009/1452.
This thesis investigates the outcomes of economic divergence during the neoliberal period in Guatemala and Costa Rica (1985-2020). The application of social capabilities: transformation, autonomy, inclusion and accountability allowed us not only to show the diverted social and economic paths, but also to inspect further and delve into the complex social dynamics in place. There was significant pro
Studieobjekt: AI-chatbots, serviceinteraktioner och kundupplevelser. Problemområde: Begränsat med forskning om serviceinteraktioner och kundupplevelser till följd av AI-chatbots. Syfte: Studiens syfte är att undersöka hur kundupplevelsen påverkas i serviceinteraktioner. Vi gör detta genom att fokusera på servicemöten samt service recovery-processer inom detaljhandeln, vården samt hotell- och tra
