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The metastatic potential of cancer cells is closely linked to their mechanical properties, and changes in these properties often correspond to the progression of the disease. To study how mechanical factors such as cell size and deformability influence the spread of cancer and the surrounding extracellular matrix, it is crucial that cancer cell populations be sorted in relevant subpopulations with
Background: – Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is rare in children, and results in kidney failure in up to one third of cases. There is very limited knowledge on kidney transplantation in childhood-onset AAV. We assessed kidney transplantation outcomes and prognostic factors in a multicentre cohort of patients with childhood-onset AAV.Methods: – Patients diag
Background: Severe Alpha-1-Antitrypsin deficiency (AATD), phenotype PiZZ, is a leading cause of liver disease in neonates, children, and adults. Nevertheless, the prevalence of liver disease and mortality within PiZZ adults remains unclear. Between 1972 and 1974, a cohort of 129 individuals with severe AATD (PiZZ) was identified through the Swedish national screening of 200,000 newborns. The cohor
Metabolic syndrome (MetS) is a cluster of cardiovascular risk factors, including abdominal obesity, insulin resistance, dyslipidemia, and hypertension. Its association with venous thromboembolism (VTE) has been inconsistently reported. We investigated the association between MetS and VTE, and the influence of sex and abdominal obesity. We included 12,788 middle-aged and older adults from the re-ex
Low back pain is common and negatively impacts quality of life and workplace productivity. However, few studies have focused on small- and medium-sized enterprises (SMEs) where risk factors are prevalent. This cross-sectional study examined the association and structural relationships between physical and social factors in low back pain among Japanese SME workers. We analyzed survey data collected
We present the design and implementation of a portable transfer system equipped with an integrated electrochemical cell that enables the controlled transfer of samples between an electrochemical environment and an ultrahigh vacuum (UHV) system without air exposure. This setup allows for the preparation of well-defined model surfaces, their electrochemical modification, and subsequent structural an
The formation of InSb quantum dots (QDs) embedded in an InAs matrix grown by molecular beam epitaxy (MBE) was studied parametrically. In particular, the effect of the sequence of the change of As2 dimers and Sb2 on the distribution of As and Sb at the InSb-QDs/InAs interface was investigated by cross-sectional transmission electron microscopy (TEM). It was shown that additional As2 above the InSb
Optimization and electrical control of photovoltaic (PV) and proton exchange membrane (PEM) electrolyzer systems are critical for efficient, scalable hydrogen production. Static coupling methods employ fixed electrical interconnections between PV arrays and the PEM stack, which cannot adapt to fluctuating irradiance or temperature. To overcome this, we propose an adaptive reconfiguration optimizat
Electrochemical reactions like water-splitting or corrosion initiate at electrode-electrolyte interface, and in some cases can also be closely linked. In particular, the oxygen evolution reaction (OER) in electrolyzers and the oxygen reduction reaction (ORR) in fuel cells are not only sluggish but can also lead to severe catalyst degradation. A fundamental understanding of these processes is there
BACKGROUND/AIM: Determining the causation of an injury in living individuals is a key task for forensic pathologists. However, little is known about sex-based differences in injury characteristics. The study aims to examine sex-based differences in single stab injuries to the trunk among assault survivors, to potentially identify injury patterns that could aid forensic assessment and help in the m
The activity and stability of an electrocatalyst is governed by the structural and chemical changes occurring at the solid–liquid interface. While single crystal electrodes have often served as model systems to elucidate structure–function relationships, extending these insights to more realistic polycrystalline electrodes requires experimental techniques with spatial resolution that can operate u
Using ultra-broadband transient terahertz (THz) spectroscopy, complemented by transient absorption (TA) and photoluminescence (PL) measurements, we directly track the generation and relaxation of photoexcited hot carriers, as well as the ultrafast formation of excitons in the transition metal phosphorus trichalcogenide NiPS3, with a temporal resolution of sub-100 fs. A subset of excitons exhibits
A computational method to simulate bimolecular quenching reactions using coarse-grained reaction-diffusion dynamics is presented and applied to the quenching of molecular photosensitizers in solution. The simulations describe photoinduced reactions involving explicit excited states of light-harvesting species together with intrinsic deactivation, as well as collision quenching from separate quench
Accumulating evidence shows that immune cells play an important role in atherosclerosis. Most attention has focused on the role of different T cell subsets, whereas the possible involvement of B cells has been less studied. In this study, we assessed the association of 2 different B cell subsets, CD19(+)CD40(+) and CD19(+)CD86(+) B cells, with risk for development of acute cardiovascular events.
Mutations in the CFTR gene result in impaired host defense during cystic fibrosis (CF), where Pseudomonas aeruginosa becomes a key pathogen. We investigated the expression pattern of the antibacterial growth factor midkine in CF and possible interference with its activity by the altered airway microenvironment. High midkine expression was found in CF lung tissue compared with controls, involving e
Background and Aim: A recent study in Indian subjects suggested common variants in apolipoprotein C3 (APOC3) (T-455C at rs2854116 and C-482T at rs2854117) to contribute to non-alcoholic fatty liver disease (NAFLD), plasma apoC3 and triglyceride concentrations. Our aim was to determine the contribution of genetic variation in APOC3 on liver fat content and plasma triglyceride and apoC3 concentratio
Increased risk of Hodgkin lymphoma (HL) associated with personal history of several autoimmune diseases (ADs), such as rheumatoid arthritis, systemic lupus erythematosus, sarcoidosis, and immune thrombocytopenic purpura, are known. Whether there are other HL-related ADs and whether the increased risk of HL after ADs holds across sex, age, year of diagnosis, or HL histological subtype is unclear. W
Surgery or radiation therapy remain the standard curative treatments for newly diagnosed prostate cancer patients. Nonetheless, these aggressive treatments are associated with decreased quality of life with altered sexual and urinary functions. The objective was a systematic review of active surveillance protocols to investigate the role of histopathology and molecular markers in the active survei
Context: Although magnetic resonance imaging (MRI) is emerging as the most commonly used imaging modality for prostate cancer (PCa) detection, treatment planning, and follow-up, its acceptance has not been uniform. Recently, great interest has been shown in multiparametric MRI, which combines anatomic T2-weighted (T2W) imaging with MR spectroscopic imaging (MRSI), dynamic contrast-enhanced MRI (DC
We report the results of an association study of melanoma that is based on the genome-wide imputation of the genotypes of 1,353 cases and 3,566 controls of European origin conducted by the GenoMEL consortium. This revealed an association between several SNPs in intron 8 of the FTO gene, including rs16953002, which replicated using 12,313 cases and 55,667 controls of European ancestry from Europe,
