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Cancer stem cells (CSCs) are relevant therapeutic targets for cancer treatment. Still, the molecular circuits behind CSC characteristics are not fully understood. The low number of CSCs can sometimes be an obstacle to carrying out assays that explore their properties. Thus, increasing CSC numbers via small molecule-mediated cellular reprogramming appears to be a valid alternative tool. Using the S

Understanding the trade-off between energy expenditure of carrying large fuel loads and the risk of fuel depletion is imperative to understand the evolution of flight strategies during long-distance animal migration. Global flyways regularly involve sea crossings that may impose flight prolongations on migrating land-birds and thereby reduce their energy reserves and survival prospects. We studied

Materials with heterogeneous microstructures have been reported to have an attractive combination of strength and ductility. This is attributed to synergistic strengthening effects from the difference in strength of fine- and coarse-grained regions. Understanding the interaction of the regions is crucial for further optimization of the microstructures. In this work, we fabricated nickel of harmoni

α-Synuclein is a small neuronal protein enriched at presynaptic termini. It is hypothesized to play a role in neurotransmitter release and synaptic vesicle cycling, while the formation of α-synuclein amyloid fibrils is associated with several neurodegenerative diseases, most notably Parkinson’s Disease. The molecular mechanisms of both the physiological and pathological functions of α-synuclein re

In this study, we present a systematic investigation of the controlled fabrication of Au-Pd barcode nanowires within nanoporous anodic aluminum oxide (NP-AAO) templates. By using a combination of in situ X-ray diffraction (XRD), focused ion beam scanning electron microscopy (FIB-SEM), and transmission electron microscopy (TEM), we elucidate the influence of template preparation methods on the resu

Characterization of emissions from fires in a laboratory-controlled environment are presented in this report. The project is initiated by the CERN HSE Unit and is called FIRIA, Fire-Induced Radiological Integrated Assessment. The objective of FIRIA is to enhance the knowledge of aerosols emitted from fires in order to develop dispersion models of radiologically-activated material in case of fire.

Aim The aim was to assess the use of multi-frequency vibrometry (MFV) in detecting diabetic peripheral neuropathy (DPN) in type 1 diabetes in comparison to nerve conduction studies (NCS) and neurothesiometer (NT). Our objectives were to examine how VPTs correlated with NCS parameters, evaluate the efficacy of MFV in distinguishing DPN as well as to investigate whether MFV procedure could be based

Segregated bimetallic nanoparticles like core-shell nanoparticles are of interest in various fields including biomedicine, catalysis, and optoelectronics. Aerosol technology is an optimal platform to control nanoparticle size, structure, and composition, which are some of the most important parameters tuning the material performance for the intended applications. Here, we develop a novel evaporato

Background: Patients with type 2 diabetes have an increased risk of death and cardiovascular events and people with diabetes or prediabetes have been found to have increased atherosclerotic burden in the coronary and carotid arteries. This study will estimate the cross-sectional prevalence of atherosclerosis in the coronary and carotid arteries in individuals with prediabetes and diabetes, compare

We study experimentally and with wave optics modelling the absorption of light in CsPbBr3perovskite nanowire arrays fabricated into periodic pores of an anodized aluminum oxide matrix, for nanowire diameters from 30 to 360 nm. First, we find that all the light that couples into the array can be absorbed by the nanowires at sufficient nanowire length. This behavior is in strong contrast to the expe

Introduction: The aim was to evaluate two biomarker scores trained to identify comorbidity burden in the prediction of specified chronic morbidities, and mortality in the general population. Methods: Cardiovascular biomarkers were measured in the cardiovascular cohort of the Malmö Diet and Cancer Study. A score of 19 biomarkers associated with Charlson Comorbidity Index (CCI) was created (BSMDC).

In the present study, three-dimensional direct numerical simulations (DNS) of experimental ammonia/air premixed jet flames with different turbulent intensities were performed. The DNS results were first compared to the measurements with good agreements. Based on the DNS data, the turbulent flame structure, stabilization mechanism and NO emission characteristics of the flames were investigated. It

Despite the potential of smart home technologies (SHT) to support everyday activities, the implementation rate of such technology in the homes of older adults remains low. The overall aim of this study was to explore factors involved in the decision-making process in adopting SHT among current and future generations of older adults. We also aimed to identify and understand barriers and facilitator

This article uses a new database of 1,891 probate inventories from rural southern Sweden to investigate the development of rural households’ productive capacity from the late 1600s to the 1860s. Both labourers and farmers improved their material living standards – as measured by the contents of probate inventories – but the labouring households’ ownership of means of production decreased over timeThis article uses a new database of 1,891 probate inventories from rural southern Sweden to investigate the development of rural households’ productive capacity from the late 1600s to the 1860s. Both labourers and farmers improved their material living standards – as measured by the contents of probate inventories – but the labouring households’ ownership of means of production decreased over time

Amyloids are elongated supramolecular protein self-assemblies. Their formation is a non-covalent assembly process and as such is fully reversible. Amyloid formation is associated with several neurodegenerative diseases, and the reversibility is key to maintaining the healthy state. Reversibility is also key to the performance of fibril-based biomaterials and functional amyloids. The reversibility

In situ catalysis studies typically correlate catalytic function and majority surface structures, but neglect that difficult-to-detect minority structures might govern catalysis. Here we use an oscillating CO:O2 gas composition to drive structural oscillations on a catalytically active Pd(100) surface and collect X-ray photoelectron spectroscopy data at high measurement frequency to demonstrate th

INTRODUCTION: Breast cancer, a leading female cancer worldwide, can be influenced by mitochondrial dysfunction. Dysregulation of mitochondria by the nuclear genome may cause breast cancer initiation and progression. However, the comprehensive investigation of mitochondrial-related genes as prognostic marker for the overall survival of early-stage breast cancer patients is still limited.METHODS: To

We have investigated the adsorption of the amyloid-forming protein a-Synuclein (aSyn) onto small unilamellar vesicles composed of a mixture of zwitterionic POPC and anionic POPS lipids. aSyn monomers adsorb onto the anionic lipid vesicles where they adopt an a-helical secondary structure. The degree of adsorption depends on the fraction of anionic lipid in the mixed lipid membrane, but one needs t

A high turnover among principals may disrupt the continuity of leadership and negativelyaffect teachers and, by extension, the students. The aim was to investigate to what extent variouswork environment factors and signs of exhaustion were associated with reported intentions tochange workplace among principals working in compulsory schools. A web-based questionnaire wasadministered twice, in 2018