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The regeneration of salamander limbs has been a special fascination among scientists and keen observers for centuries. Perhaps due to how closely the salamander's limb anatomically mirrors our own, a grand aspiration of regenerative medicine has been to provoke such a process following injury or loss of human limbs. Research in the last century has focused on understanding the blastema, a prolifer
COVID-19 has affected the daily activities of people worldwide. Recommendations introduced to reduce the spread of the virus led to increased use of Information and Communication Technologies (ICT) to meet everyday needs. Such rapid digitalization had not been seen previously and not been possible to study before. Hence, this study aimed to identify and describe self-reported changes in usage of a
INTRODUCTION: Parkinson's disease (PD) is the second most common neurodegenerative disorder, increasing both in terms of prevalence and incidence. To date, only symptomatic treatment is available, highlighting the need to increase knowledge on disease etiology in order to develop new therapeutic strategies. Hemizygosity for the gene Engrailed-1 ( En1), encoding a conserved transcription factor ess
The last couple of decades have seen an explosion of novel colloidal drug delivery systems, which have been demonstrated to increase drug efficacy, reduce side-effects, and provide various other advantages for both small-molecule and biomacromolecular drugs. The interactions of delivery systems with biomembranes are increasingly recognized to play a key role for efficient eradication of pathogens
The reactivity of oxide surfaces is often attributed to formation and annihilation of oxygen deficient sites, which undergo complex structural rearrangements in the process. A prototypical example is VOx/TiO2 catalysts, widely used for e.g. selective catalytic reduction (SCR) of NOx emissions, where the possible effect of the supporting TiO2 surface structure has been much debated. Here, we presen
The use of ETEM in oxidation studies of carbon nanostructures such as CB has revealed new, and confirmed previously suggested, oxidation mechanisms. However, the influence of the electron beam on the dynamic oxidation processes must be well understood in order to connect the results to the real world. To date, there are few studies reporting any quantification of the effect1,2. To better understan
Objective: We aimed to compare the genetic contribution to osteoarthritis (OA) versus other rheumatic/musculoskeletal diseases (RMDs) in the same population and to explore the role for any shared genetics between OA and other RMDs. Methods: In 59,970 Swedish twins aged 35 years or older, we estimated the heritability (the variance explained by genetic factors) of OA in peripheral joints, back and
Core–shell structural ZnSeTe/ZnSe/ZnS quantum dots (QDs) have attracted great attention for advanced illumination and displays because of their environmentally friendly composition, but still suffering from poor photoluminescence (PL) and electroluminescence (EL) performance due to severe non-radiative charge recombination. Herein, a stepwise injection shell growth process to manipulate the monome
Advanced breast cancers represent a major therapeutic challenge due to their refractoriness to treatment. Cancer-associated fibroblasts (CAFs) are the most abundant constituents of the tumor microenvironment and have been linked to most hallmarks of cancer. However, the influence of CAFs on therapeutic outcome remains largely unchartered. Here, we reveal that spatial coincidence of abundant CAF in
Aim: In neuroendocrine cells, large dense-core vesicles (LDCVs) undergo highly regulated pre-fusion processes before releasing hormones via membrane fusion. Significant heterogeneity has been found for LDCV population based on the dynamics of membrane fusion. However, how the pre-fusion status impacts the heterogeneity of LDCVs still remains unclear. Hence, we explored pre-fusion determinants of h
Poor self-rated health (SRH) is associated with incident arterial cardiovascular disease in both sexes. Studies on the association between SRH and incident venous thromboembolism (VTE) show divergent results in women and no association in men. This study focuses on the association between change in SRH and incident VTE in a cohort of 11,558 men and 6682 women who underwent a baseline examination a
Photocatalysis plays a crucial role in harnessing renewable energy by efficiently converting solar energy into chemical energy. Adequate cognition of photogenerated charge carrier dynamics in photocatalysis is the key to realizing efficient solar energy utilization, and provides guidance for breaking through the efficiency bottleneck. However, a convincing correlation between those photophysical p
Background: Pandemics are linked with declining birth rates, but little is known about how the COVID-19 pandemic has influenced childbearing decisions. We aimed to investigate the associations between the COVID-19 pandemic and reproductive decisions, specifically to identify potential changes in the frequency of deliveries and induced abortions in Skåne, Sweden. Methods: Using the Skåne Healthcare
Background and aims: Despite firm evidence for an association between long-term ambient air pollution exposure and cardiovascular morbidity and mortality, results from epidemiological studies on the association between air pollution exposure and atherosclerosis have not been consistent. We investigated associations between long-term low-level air pollution exposure and coronary atherosclerosis. Me
Traditional methods to study electrochemical (EC) processes, although successful, are based on current/voltage measurements, providing information about performances rather than offering a direct observation of chemical and structural changes occurring at the electrode surface. These processes are localized at the electrode-electrolyte interface, the structure of which is the main determinant of t
Objective: To investigate the associations between rheumatic and musculoskeletal diseases (RMDs) and incident dementia using population register-based data. Methods: This nested case-control study was conducted based on a cohort of residents in the Skåne region, Sweden, aged 50 years and older in 2009 without doctor-diagnosed dementia during 1998 to 2009 (n = 402,825). Individuals with a new main
INTRODUCTION: Antineoplastic drugs (ADs) are frequently used pharmaceuticals in the healthcare, and healthcare workers can be occupationally exposed to ADs. Monitoring of surface contamination is a common way to assess occupational exposure to ADs. The objective was to develop and validate a sensitive and quantitative monitoring method to determine surface contaminations of Pt as a marker for Pt-c
Segmentation of diagnostic radiography images using deep learning is progressively expanding, which sets demands on the accessibility, availability, and accuracy of the software tools used. This study aimed at evaluating the performance of a segmentation model for digital breast tomosynthesis (DBT), with the use of computer-simulated breast anatomy. We have simulated breast anatomy and soft tissue
Efficient techniques for separating target cells from undiluted blood are necessary for various diagnostic and research applications. This paper presents acoustic focusing in dense media containing iodixanol to purify peripheral blood mononuclear cells (PBMCs) from whole blood in a label-free and flow-through format. If the blood is laminated or mixed with iodixanol solutions while passing through
