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Flavin-dependent halogenases regioselectively introduce halide substituents into electron-rich substrates under mild reaction conditions. For the enzyme Xcc4156 from Xanthomonas campestris, the structure of a complex with the cofactor flavin adenine dinucleotide (FAD) and a bromide ion would be of particular interest as this enzyme exclusively brominates model substrates in vitro. Apo Xcc4156 crys
Meeting the goals set out in the Paris Agreement will require rapid and deep reductions of greenhouse gas emissions (GHG) across all sectors of the global economy. Like all major societal transformations, this climate transition will impact both social and technical aspects of society and, depending on how it evolves, will reallocate social and economic benefits and costs differently. Recognising
Current climate models and observations indicate that atmospheric circulation is being affected by global climate change. To assess how these changes may affect nocturnally migrating bird populations, we need to determine how current patterns of wind assistance at migration altitudes will be enhanced or reduced under future atmospheric conditions. Here, we use information compiled from 143 weather
The combination of digital breast tomosynthesis (DBT) with other imaging modalities has been investigated in order to improve the detection and diagnosis of breast cancer. Mechanical Imaging (MI) measures the stress over the surface of the compressed breast, using a pressure sensor, during radiographic examination and its response has shown a correlation with the presence of malignant lesions. Thu
We consider partitioned time integration for heterogeneous coupled heat equations. First and second order multirate, as well as time-adaptive Dirichlet-Neumann Waveform relaxation (DNWR) methods are derived. In 1D and for implicit Euler time integration, we analytically determine optimal relaxation parameters for the fully discrete scheme. We test the robustness of the relaxation parameters on the
Electron transporting layers facilitating electron extraction and suppressing hole recombination at the cathode are crucial components in any thin-film solar cell geometry, including that of metal–halide perovskite solar cells. Amorphous tantalum oxide (Ta2O5) deposited by spin coating was explored as an electron transport material for perovskite solar cells, achieving power conversion efficiency
Energy efficiency in buildings remains an important priority for the European Union. Towards that direction, therole of the one-stop-shops (OSSs) that will offer integrated renovation services has been further enhanced. Thepaper aims to compare public and private-driven OSSs to increase knowledge regarding the way they operate.The business models of ten OSSs for renovation of residential buildings
The focus of this paper is an interdisciplinary approach towards the consumption of novel seaweed foods. Combining social science, food science, and a chemical and biotechnological perspective, we ask the following questions: How do we gain knowledge about the consumer's approach to new marine products on the market? What kinds of methods are suitable and possible to use? In what way can we combin
The aim of this study is to, based on a theory of learning, compare in what ways two different cases of the use of self-monitoring videotapes for developing social skills in adolescents with autism spectrum disorder (ASD) facilitates social behavior studied with a micro-level approach. Two verbal 15-year-old male students with ASD and cognitive disabilities were filmed for 20 min in three differen
INTRODUCTION: Recently, an increasing number of tau tracers have become available. There is a need to standardize quantitative tau measures across tracers, supporting a universal scale. We developed several cortical tau masks and applied them to generate a tau imaging universal scale. METHOD: One thousand forty-five participants underwent tau scans with either 18F-flortaucipir, 18F-MK6240, 18F-PI2
The incorporation of machine learning methods into proteomics workflows improves the identification of disease-relevant biomarkers and biological pathways. However, machine learning models, such as deep neural networks, typically suffer from lack of interpretability. Here, we present a deep learning approach to combine biological pathway analysis and biomarker identification to increase the interp
The current rate of residential building renovations in Europe is inadequate and attributable to the lack of integrated solutions in the market supported by appropriate business models. One-stop-shop (OSS) offers an innovative business approach, and it is acknowledged by the European Commission, in the Directive 2018/844/EU, as a transparent advisory and facilitating tool for the establishment of
Food, hygiene, and safety are critical in healthcare institutions, especially those in which patients are vulnerable against diseases triggered by food prepared under improper conditions. In the United Kingdom, almost 400 healthcare institutions were found to need significant improvements to their food preparation standards (ITV News, 2016). Such institutions still rely on traditional pen and pape
Prediction of analyte retention times requires prior knowledge of the column void volume, the measurement of which is still highly contested within the literature and therefore experimental based prediction is often used. In this study, we investigated deuterated acetonitrile as an isotopically labelled mobile phase component to observe its elution behaviour in a binary mixture with water at 25 di
Recent measurements of collective effect-like signals in small collision systems has highlighted the need for new models to explain these phenomena. One good candidate for such a model is the AMY QCD effective kinetic theory, which is valid for systems in- and out-of-equilibrium. This thesis is a collection of four papers which all investigate how to apply AMY kinetic theory to explain the evoluti
Glucagon-like peptide-1 (GLP-1) receptor agonists are established pharmaceutical therapies for the treatment of type 2 diabetes and obesity. They mimic the action of GLP-1 to reduce glucose levels through stimulation of insulin secretion and inhibition of glucagon secretion. They also reduce body weight by inducing satiety through central actions. The GLP-1 receptor agonists used clinically are ba
