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Background: Levodopa–entacapone–carbidopa intestinal gel (LECIG) was introduced on the Swedish market in 2019. The therapy is aimed at patients with Parkinson's disease (PD) with fluctuations and dyskinesias. Long-term efficacy and safety data are lacking. Objective: To investigate the efficacy, tolerability, and safety of LECIG in regular clinical practice for Parkinson's disease in Sweden. Metho
Research on how children are affected by their sibship size, i.e., their number of siblings, faces a serious hurdle because sibship size is endogenous in the model. The current “gold standard” method to solve this is to use (parity-specific) twin births as instrumental variables. The purpose of this chapter is twofold. Firstly, it introduces instrumental variable methods in general. Secondly, it a
Recent scholarship in critical intelligence studies emphasizes the role of informal actors in democratic oversight, encouraging increased attention to practices and struggles of accountability. Less probed are the fundamental conditions enabling the work of informal oversight actors, and current struggles over such conditions. This article turns to the case of Sweden, a top-ranking state in the pr
This conceptual article examines the relational dynamic between the research field focusing on the far right and those critical scholars that endeavour to undertake these studies. It is theoretically anchored in the field of political science scholarship that recognises the key role played by gender in understanding both the ideological underpinnings and the workings of various far-right entities
When developing general-purpose robot software components, we often lack complete knowledge of the specific contexts in which they will be executed. This limits our ability to make predictions, including our ability to detect program bugs statically. Since running a robot is an expensive task, finding errors at runtime can prolong the debugging loop or even cause safety hazards. This paper propose
In northern countries, the climate, and consequently the use of studded tyres and winter traction sanding, causes accumulation of road dust over winter and spring, resulting in high PM10 concentrations during springtime dusting events. To quantify the dust at the road surface, a method—the wet dust sampler (WDS)—was developed allowing repeatable sampling also under wet and snowy conditions. The pr
Due to increasing plastic production, the continuous release of primary and secondary nanoplastic particles (NPs, <1 μm) has become an emerging contaminant in terrestrial environments. The fate and transport of NPs in subsurface environments remain poorly understood, largely due to the complex interplay of mineralogical, chemical, biological, and morphological heterogeneity. This study examines in
The increasing demand for renewable energy accounts for the DC microgrid concept, facilitating the integration of photovoltaic (PV) modules and battery energy systems (BESS) into a common DC bus. In light of this, bipolar DC-DC converters can result in two symmetric DC buses that provide more flexibility. This article presents a hybrid bipolar converter by merging a single-ended primary-inductor c
Power supplies for microelectronic systems, battery chargers, wind energy applications, electric appliances in the household and dc motor drives require AC-DC converters. The proposed bridgeless Cuk PFC converter in this paper is featured with common ground, transformerless structure, and clear energy delivery process. The absence of bridge rectifiers, transformer and the presence of only two semi
The surging demand for Intelligent Transportation Systems (ITS) to deliver advanced train-related Information for dispatchers and passengers has spurred the development of advanced train delay prediction models. Despite considerable efforts devoted to developing methodologies that can be used to model train operation conditions and produce anticipated train delays, the evaluation strategies for tr
Exceptional are the instances where explicit solutions to optimal control problems are obtainable. Of particular interest are the explicit solutions derived for minimax problems, as they provide a framework for addressing challenges involving adversarial conditions and uncertainties. This thesis presents explicit solutions to a novel class of minimax optimal control problems for positive linear sy
Aim: The aim of this study was to explore the role of managers and employees with an assigned responsibility (i.e. inspirers) when integrating recovery-enhancing activities into everyday work in a primary health care setting. Background: The possibility of recovery during the workday is essential for employee wellbeing. However, the literature on workplace interventions focusing on recovery is sca
However, it is not clear to what extent corresponding perceptual preferences for intonational deviations might rely on listeners’ instrumental expertise or such contextual aspects as the metrical placement of tones. We investigated higher-education music students’ perceptual preferences for melodic intonation of local leading tones in unaccompanied classical violin performances. Recordings of 12 e
Animals communicate with a staggering diversity of rhythmic signals, yet behind all this diversity lies a small number of ethological mechanisms. In this chapter, we provide a quick review of how animal produce rhythmic signals based on these mechanisms, which span tremulation, percussion, bodily displays, stridulation, tymbalation, aerodynamic sound production (including vocalisation), as well as
Nanotechnology offers promising perspectives for revolutionizing agriculture by enhancing productivity and sustainability. Although the global agricultural nanotechnology market was valued at US$ 352.4 billion in 2023 and is estimated to reach US$ 868.9 billion by 2031, concerns about adverse environmental effects persist. This review summarizes the latest developments and perspectives of nanotech
Objectives: This is a protocol for a Cochrane Review (intervention). The objectives are as follows:. To assess the benefits and harms of individualized developmental care interventions for promoting development and preventing morbidity in preterm infants.
Planning and navigation in real-time traffic is challenging, since the driving environment (e.g., road network and infrastructure) is complex and the accurate prediction of surrounding vehicles is hard. To address this, this paper proposes an environment and uncertainty-aware robust motion-planning strategy. The method achieves environment awareness by considering road-geometry constraints in the
