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The TRPV1 receptor (transient receptor potential vanilloid 1) is a nonspecific membrane-bound cation channel, which plays an important role in nociception and pain transmission, the nerve-response to possibly dangerous stimuli. It is known that TRPV1 can be modulated by a variety of stimuli, amongst which heat, protons and chemical compounds, such as capsaicin, are the most known activators. This
Life-sciences have developed at a rapid pace during recent years. From experiments investigating single molecules such as proteins or single genes to large scale projects mapping entire organisms in one single experiment. However, data generated from this kind of large scale projects need to be interpreted and integrated with the base of prior knowledge in an efficient, reliable and correct way. T
The Swedish power grid is actively balanced in order to maintain the nominal frequency of 50 Hz. Today, this is mostly done through flexible power generation. Emerging markets, allowing consuming resources to participate in balancing the grid, have the potential to increase the stability of the grid. This master thesis aimed to investigate the consequences and possibilities of using variable air v
Knowledge inequalities persist between the Global North and the Global South, but also within countries between privileged and underprivileged segments of society. The purpose of this study is to understand the motives of researchers from basic science and technology to investigate on socially demanded issues as well as the obstacles they encounter. The study is based on the experiences from eleve
As commodities are becoming more popular and accessible assets for speculative and hedging purposes, the limited research regarding risk management for said asset-class justifies further contribution to the deficient output. Many previous studies have highlighted the extraordinary high volatility, with non-linear and clustering characteristics associated with commodities. Hence, incorporating vola
Thesis purpose: The purpose of this study is to gain knowledge about baby boomers’ motivations for using either digital or analogue touchpoints in the high involvement customer journey. This ultimately contributes to an increased understanding of the high involvement customer journey. Methodology: A qualitative study with social constructionism as the research philosophy, where an abductive appro
To optimize the weights in an artificial neural network most methods rely gradients, which are not always obtainable or desirable. Evolutionary algorithms are instead based on Darwinian evolution where no derivative is needed. These algorithms have a set of strategy parameters that can be dynamically updated during the search to increase performance. Two ways of updating the parameters are the so
Styvhetsförändringar i bröstvävnad är ofta kopplade till en patologisk förändring. Vissa cancertyper som infiltererande duktalt carcinom kan vara åtta gånger så styv som fettvävnaden runt omkring. Genom att komprimera bröstet och mäta trycket på bröstets yta har man identifierat att det blir en lokal förhöjning i tryck där det finns en tumör. Med hjälp av den här typen av mekanisk avbildning av brA change in stiffness of breast tissue is often connected to a pathological change. Some types of breast cancer such as infiltrating ductal carcinoma can be up to eight times stiffer than fat tissue. It has been found that during compression of the breast there will be a local area of relatively high stress at the breast surface at the location of a tumour. This type of mechanical imaging of the b
This Master’s thesis investigates if a previously integrated Simulink based vehicle model works for testing and verifying software on an ECU (electronic control unit) used to control a four-wheel drive coupling in cars. The testing is done through a specific program called CANoe that allows the tester to both develop and run test cases. This work also investigates the possibility to use static eva
As we’re living in a modern society, most of us have been connected to the water and electricity grid, However, there’re still billions of people who are still lack of reliable water and electricity resource. In some developing countries like India and Philippines, the demand for electricity and water are far more than actual production, which causes frequent electricity and water shortage problem
Since their emergence in the 1950’s, ice cores have ventured from being scientific objects of concern to a limited number of glaciologists to becoming one of the most iconic representations of anthropogenic climate change. This thesis aims to historicize the way in which ice cores became enrolled into climate discourse, particularly emphasizing the production and representation of temporalities of
Problem - Skanska Industrial Solutions AB lays asphalt over a wide geographical area, and never in the same place and is also a work that is dependent on the weather. Asphalt is a product with low to no capacity to be stored. These factors contribute to a distribution that has the necessity to follow the JIT-principles. The asphalt production is in of a steady flow of asphalt being transported fro
En allt mer konkurrensinriktad marknad har ökat behovet för företag att fokusera på sin kärnkompetens. Givet denna utveckling har större nätverk med fler involverade parter vuxit fram, vilket lett till att fler företag börjat vända sig till en fjärde part. Fjärdepartslogistik innefattar en komplex integrering av försörjningskedjans alla komponenter och ett för kunden större överlåtande av sin verk
Cross-functional teams and meetings are recurrent structuring tools in contemporary knowledge organisations. They are recommended as solutions to enhance innovation and creativity. Current research gathers a myriad of reference to the benefits of such tools, but studies of their potential negative effects remain limited. This paper is specifically concerned with the effect of interdisciplinary tea
The purpose of the report is to study the yellow cycle route in the city of Lund and investigate the inadequacies that could be found on today's route. The yellow cycle route goes from Dalby in the south to Gunnesbo in the north. The method used to answer the questions of this report is literature study and a technical inventory. The analysis of the studied route is based on Lund’s cycle strat
Value at Risk (VaR) is a popular measurement for valuing the risk exposure. Correct estimates of VaR are essential in order to properly be able to monitor the risk. This thesis examines a copula approach for estimating VaR for portfolios of commodities. The predictions are made from a semi- parametric model with Monte Carlo methods. The underlying model is constructed by choosing the best fit from
Removal of disease-driving inflammatory leucocytes is central to resolution of inflammation. The current pharmacological dogma teaches leucocyte elimination through apoptosis followed by phagocytosis. However, actual resolving roles of apoptotic-phagocytic processes have been difficult to demonstrate in the major diseases that are characterized by mucosal tissue inflammation. Many current in vivo
The overall aim of this research was to investigate the safety of oral care in terms of intracranial dynamics and changes in oral health during intubation and 48 hours after extubation among neuroscience intensive care unit (NICU) patients. Additional aims included comparison of a comprehensive oral care protocol (i.e., tongue scraping, electric toothbrush, non-foaming toothpaste, and application
In this paper, optimization problems arising in model predictive control (MPC) and in distributed MPC aresolved by applying a fast gradient method to the dual of the MPC optimization problem. Although the development of fast gradient methods has improved the convergence rate of gradient-based methods considerably, they are still sensitive to ill-conditioning of the problem data. Since similar opti
