Filetype
Objective: Adverse event (AE) monitoring is central to assessing therapeutic safety. The lack of a comprehensive framework to define and grade maternal and fetal AEs in pregnancy trials severely limits understanding risks in pregnant women. We created AE terminology to improve safety monitoring for developing pregnancy drugs, devices and interventions. Method: Existing severity grading for pregnan
Recent advances in genome editing have brought new hopes for personalized and precision medicine but have also dramatically facilitated disease modeling studies. Combined with reprogramming approaches, stem cells and differentiation toward neural lineages, genome engineering holds great potential for regenerative approaches and to model neurological disorders. The use of patient-specific induced p
Sweden has the largest forest cover in the European Union, and for decades, Sweden's forest industry has pursued intensive forest management through tree plantations and clear-cutting in order to maximize wood production. The Swedish forestry sector is increasingly under pressure to transition away from intensive clear-cut forest management, but other forest management models are still a niche in
Paraffin wax and various nanoparticles (CuO, Al2O3 and Fe3O4) were used as matrix and heat conduction enhancer of phase change materials (PCMs), respectively. The dispersant Span 80 was added into the nanocomposite to provide stable PCMs. Based on analyses of melting and freezing curves and infrared thermal imaging tests, the phase change latent heat, viscosity, and thermal conductivity of the nan
Almost all species face some degree of predation risk, and, hence, evolution has produced a plethora of anti-predator defences. However, anti-predator strategies require resources, and the prevailing risk of becoming prey is influenced by many factors and rarely constant across time and space. Evolution has therefore favoured the development of phenotypic plasticity in anti-predator defences. The Almost all species face some degree of predation risk, and, hence, evolution has produced a plethora of anti-predator defences. However, anti-predator strategies require resources, and the prevailing risk of becoming prey is influenced by many factors and rarely constant across time and space. Evolution has therefore favoured the development of phenotypic plasticity in anti-predator defences. The
Importance: Reflex syncope is the major cause of transient loss of consciousness, which affects one-third of the population, but effective treatment for individuals with severe syncope is lacking. Better understanding of reflex syncope predisposition may offer new therapeutic solutions.Objectives: To determine the familial risk of syncope in first-, second-, and third-degree relatives of affected
In the European Union the Annexes of its chemical legislation (REACH) were revised and now clarify the technical data requirements for nanomaterials (NMs). These new provisions, effective from January 1, 2020, introduce requirements for manufacturers, importers and downstream users regarding registration and safety assessment of NMs. This study aims to assess the availability and suitability of me
A recurrent concern in nature conservation is the potential competition for forage plants between wild bees and managed honey bees. Specifically, that the highly sophisticated system of recruitment and large perennial colonies of honey bees quickly exhaust forage resources leading to the local extirpation of wild bees. However, different species of bees show different preferences for forage plants
The use of 3D city models is changing from visualization to complex use cases where they act as 3D base maps. This requires links to registers and continuous updating of the city models. Still, most models never change or are recreated instead of updated. This study identifies obstacles to version management of 3D city models and proposes recommendations to overcome them, with a main focus on the
Spatially-distributed values of glacier aerodynamic roughness (z0) are vital for robust estimates of turbulent energy fluxes and ice and snow melt. Microtopographic data allow rapid estimates of z0 over discrete plot-scale areas, but are sensitive to data scale and resolution. Here, we use an extensive multi-scale dataset from Hintereisferner, Austria, to develop a correction factor to derive z0 v
A discussion of the different and often conflicting demands on the documentation of documents posed by material bibliography and immaterial textual criticism.
Abstract in Uncoded languages Namen prispevka:Namen prispevka je analizirati ponovno podane izkušnje 27-ih preživelih vojne v Bosni in Hercegovini v 90-ih letih prejšnjega stoletja. V pripovedih smo pregledali verbalne znake sprave in pomiritve ter analizirali opisane izraze za spravo. Metode: Gradivo za raziskavo je bilo zbrano s kvalitativnimi intervjuji 27-ih posameznikov, ki so preživeli vojnoPurpose: The aim of this article was to analyze the retold experiences of 27 survivors from the 1990s war in Bosnia and Herzegovina. I have examined verbal markers of reconciliation and implacability and analyzed the described terms for reconciliation that are being actualized in the narratives. Design: The material for the study was gathered through qualitative interviews with 27 individuals who
OBJECTIVE: The interface of a computerized decision support system is crucial for its acceptance among end users. We demonstrate how combined bar-line charts can be used to visualize predictions for individual patients from logistic regression models. STUDY DESIGN AND SETTING: Data from a previous diagnostic study aiming at predicting the immediate risk of acute coronary syndrome (ACS) among 634 p
BACKGROUND: The aim of this retrospective matched cohort study was to evaluate the rate of recurrence among women with delayed large flap breast reconstruction after mastectomy for breast cancer. The recurrence rate among women treated at a single hospital was compared with that in an individually matched control group of women with breast cancer who did not have reconstruction after mastectomy. M
Background Increased cancer risk after psoriasis has been observed in previous studies, whereas little is known about the prognosis in cancer patients with previously diagnosed psoriasis. Objectives We aimed at examining the cancer-specific and overall mortality among psoriatic cancer patients compared with the reference population. Methods The population-based Swedish registers were used to ident
Modifiable risk factors for cardiovascular disease include overweight, which is prevented by healthy diet and physical activity. Recently settled migrants may have varying levels of exposure to health information. Therefore, the objectives of this study were to explore the associations between self-reported information on healthy diet and on physical activity and overweight and the possible modifi
Abstract Objective. To increase the accuracy of estimated GFR (eGFR) from creatinine overall and at measured GFR ≥90 mL/min per 1.73 m(2) by revising the Lund-Malmö (LM) equations, to elaborate on more complex forms to improve the LM and CKD-EPI equations further, and to assess benefits of adding lean body mass (LBM). Material and methods. Swedish Caucasians (n = 850, 376 women; median 60, range 1
BACKGROUND: Refugee women have a high risk of coronary heart disease with low physical activity as one possible mediator. Furthermore, cultural and environmental barriers to increasing physical activity have been demonstrated. The aim of the study was to evaluate the combined effect of an approximate 6-month primary health care- and community-based exercise intervention versus an individual writte
Mucosal surfaces of the reproductive tract as well as their secretions have important roles in preventing sexual transmission of HIV-1. In the current study, the majority of the intrinsic anti-HIV-1 activity of human seminal plasma (SP) was determined to reside in the cationic polypeptide fraction. Antiviral assays utilizing luciferase reporter cells and lymphocytic cells revealed the ability of w
We use density-matrix simulations to study the performance of three distance three quantum error correction (QEC) codes in the context of the rare-earth (RE) ion-doped crystal platform for quantum computing. We analyze pseudothresholds for these codes when parallel operations are not available, and examine the behavior both with and without resting errors. In RE systems, resting errors can be miti
