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Endogenous Sex Steroids and Risk of Cervical Carcinoma: Results from the EPIC Study

Background: Epidemiologic data and animal models suggest that, despite the predominant role of human papillomavirus infection, sex steroid hormones are also involved in the etiology of invasive cervical carcinoma (ICC). Methods: Ninety-nine ICC cases, 121 cervical intraepithelial neoplasia grade 3 (CIN3) cases and 2 control women matched with each case for center, age, menopausal status and blood

Determinants of serum levels of vitamin D: a study of life-style, menopausal status, dietary intake, serum calcium, and PTH

Background: Low blood levels of vitamin D (25-hydroxy D3, 25OHD3) in women have been associated with an increased risk of several diseases. A large part of the population may have suboptimal 25OHD3 levels but high-risk groups are not well known. The aim of the present study was to identify determinants for serum levels of 25OHD3 in women, i.e. factors such as lifestyle, menopausal status, diet and

Carbon Monoxide Expedites Metabolic Exhaustion to Inhibit Tumor Growth

One classical feature of cancer cells is their metabolic acquisition of a highly glycolytic phenotype. Carbon monoxide (CO), one of the products of the cytoprotective molecule heme oxygenase-1 (HO-1) in cancer cells, has been implicated in carcinogenesis and therapeutic resistance. However, the functional contributions of CO and HO-1 to these processes are poorly defined. In human prostate cancers

Area-aggregated assessments of perceived environmental attributes may overcome single-source bias in studies of green environments and health: results from a cross-sectional survey in southern Sweden

Background: Most studies assessing health effects of neighborhood characteristics either use self-reports or objective assessments of the environment, the latter often based on Geographical Information Systems (GIS). While objective measures require detailed landscape data, self-assessments may yield confounded results. In this study we demonstrate how self-assessments of green neighborhood enviro

Welfare as a means for political stability : a law and society analysis

There have been extensive discussions in academic circles of why some countries develop into welfare states while others do not. Two main factors mentioned in these discussions are economic growth and the need for political stability. In these discussions, the example of Sweden, where the welfare state allegedly emerged from a ‘culture of consensus’, has often been treated as an historic exception

Adaptive capacity : from coping to sustainable transformation

People’s accumulated local capacity is increasingly recognized to be critical in enhancing disaster resilience and transformation. Nevertheless, citizens’ coping strategies are little known or documented, and hardly considered in city authorities’ and aid organizations’ work. Against this background, this study provides an overview and systematization of citizens’ strategies to cope with increasin

Packaging impact on consumer experience : voice of the E-customer

With the growth of e-commerce, understanding the nuances of packaging performance and consumer expectations has become essential to enhancing the customer experience. In e-commerce, packaging is a key component of the overall consumer experience, directly influencing perceptions and expectations. Despite its importance, packaging often remains overlooked and is significantly understudied. This exp

Genomics of stroke recovery and outcome

The understanding of genomics has improved tremendously during the last decades. The concept of recovery and outcome after stroke has also progressed during this time. However, the connection between genomics and stroke recovery has only begun to emerge in a more structural and comprehensive way. Different types of outcomes and recovery occur after stroke. This depends on domain of neurological de

Microscopic colitis and risk of venous thromboembolism : A nationwide matched cohort study

Introduction: Inflammatory diseases have been associated with increased risk of venous thromboembolism (VTE). However, data on VTE is lacking in large population-based cohorts of microscopic colitis (MC). Methods: This study included all Swedish adults with incident MC without prior VTE (1990-2017; n=12,489; follow-up until 2021). MC and subtypes (collagenous colitis and lymphocytic colitis) were

The State of Electrodeposited Sn Nanopillars within Porous Anodic Alumina from In-situ X-ray Observations

Porous anodic alumina (PAA) can be used as a template for controlled electrodeposition and growth of nano-structures, it is also essential for long-lasting decorative coloring of aluminum. We have investigated the deposition of Sn nanopillars into PAA in-situ, with Grazing transmission small angle X-ray scattering, X-ray fluorescence and X-ray absorption near edge structure spectroscopy. An accumu

Comparison of the C-REX LapAid and Circular Stapled Colorectal Anastomoses in an Experimental Model

The rate of colorectal anastomotic leakage has remained unchanged for the last decades. The limitations of current anastomotic methods have generated an interest in alternative anastomotic techniques, such as compression anastomosis. The aim of this experimental study was to evaluate the early mechanical strength in left colonic anastomoses, comparing C-REX LapAid and circular stapled anastom

Tetrabromobenzene-based molecular alloys - a tool for tailoring the temperature of the thermosalient phase transition

A series of molecular alloys of 1,2,4,5-tetrabromobenzene and 1,2,4,5-tetrachlorobenzene with varying compositions were prepared in an attempt to obtain jumping crystals with adjustable temperature of thermosalient phase transition. Molecular alloys were studied with a combination of thermal and structural techniques (DSC, SCXRD, XRPD, hot-stage microscopy). Alloys with a high 1,2,4,5-tetrabromobe

Alcohol and smoking habits in association with hepatocellular carcinoma risk

We assessed hepatocellular carcinoma (HCC) risk associated with smoking and alcohol consumption and their interactions, using both questionnaire data and objective serum biomarkers. Information on smoking and alcohol consumption was collected at baseline from 450,112 participants of the EPIC cohort, among whom 255 developed HCC after a median follow-up of 14 years. In a nested case–control subset

An Exercise Therapists' Guide to Neuromuscular Exercise for People With Knee or Hip Osteoarthritis

BACKGROUND: Neuromuscular exercise is commonly used in knee injury prevention programs and in rehabilitation following knee injury, and can also be used to address functional impairments is middle-aged and older individuals with knee and hip osteoarthritis (OA). CLINICAL QUESTION: What is neuromuscular exercise for OA? Why should clinicians use it? And how? Nine themes of common questions from exe

Association between Year of Birth and 1-Year Survival among Extremely Preterm Infants in Sweden during 2004-2007 and 2014-2016

Importance: Since 2004-2007, national guidelines and recommendations have been developed for the management of extremely preterm births in Sweden. If and how more uniform management has affected infant survival is unknown. Objective: To compare survival of extremely preterm infants born during 2004-2007 with survival of infants born during 2014-2016. Design, Setting and Participants: All births at

Conducting a registry-based randomised trial (REDOX) in chronic respiratory failure : experiences and advice

Registry-based randomised controlled trials (R-RCTs) represent a paradigm shift in research, with the potential to accomplish pragmatic but large trials with high external validity. In this paper, we review our experiences from planning and performing the REgistry-based randomised controlled trial of treatment Duration and mortality in long-term OXygen therapy (REDOX) trial, the first R-RCT within

Effects of free omega-3 carboxylic acids and fenofibrate on liver fat content in patients with hypertriglyceridemia and non-alcoholic fatty liver disease : A double-blind, randomized, placebo-controlled study

Background: Treatment with omega-3 fatty acids and fenofibrates reduces serum triglyceride levels, but few studies have compared the effect of these agents on liver fat. Objective: The aim of the EFFECT I trial (NCT02354976) was to determine the effects of free omega-3 carboxylic acids (OM-3CA) and fenofibrate on liver fat in overweight or obese individuals with non-alcoholic fatty liver disease a

Public health nurses’ experiences of using interpreters when meeting with Arabic-speaking first-time mothers

Objectives: The aim of this study was to investigate public health nurses’ experiences of using interpreters when meeting with Arabic-speaking first-time mothers. Design and Sample: An inductive qualitative design was used. Individual interviews were conducted with Swedish public health nurses (n = 11) with experience of working in child health care with interpreters when meeting with Arabic-speak