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APOE ε4 is associated with younger age at ischemic stroke onset but not with stroke outcome

Stroke outcome is determined by a complex interplay, where age and stroke severity are predominant predictors. Studies on hemorrhagic stroke indicate that APOE genotype is a predictor of poststroke outcomes,1,2 but results from studies on ischemic stroke are more conflicting.1,3 There is 1 study suggesting an influence of APOE genotype on age at ischemic stroke onset,4 and sex-specific effects on

How Companies Use OSS Tools Ecosystems for Open Innovation

Moving toward the open innovation (OI) model requires multifaceted transformations within companies. It often involves giving away the tools for product development or sharing future product directions with open tools ecosystems. Moving from the traditional closed innovation model toward an OI model for software development tools shows the potential to increase software development competence and

The Long-Lasting Influenza : The Impact of Fetal Stress During the 1918 Influenza Pandemic on Socioeconomic Attainment and Health in Sweden, 1968–2012

The 1918 influenza pandemic had not only a massive instant death toll but also lasting effects on its survivors. Several studies have shown that children born in 1919, and thus exposed to the H1N1 virus in utero, experienced worse health and socioeconomic outcomes in older ages than surrounding birth cohorts. This study combines several sources of contemporary statistics with full-population indiv

Benefit from extended surveillance interval on colorectal cancer risk in Lynch syndrome

Aim: Although patients with Lynch syndrome have an increased risk of developing colorectal cancer, surveillance can reduce morbidity and mortality. Whether or not affected individuals benefit from lifetime surveillance depends on individual factors and patient adherence, and these may vary, complicating risk modelling. The aim of this study was to identify individual factors which influence patien

Timing of preoperative antibiotics for knee arthroplasties : Improving the routines in Sweden

BACKGROUND: A slight increase in revisions for infected joint arthroplasties has been observed in the Nordic countries since 2000 for which the reasons are unclear. However, in 2007 a Swedish study of the timing for prophylactic antibiotics in a random sample of knee arthroplasties found that only 57% of the patients had received the antibiotic during the optimal time interval 45-15 minutes before

Child-Centred Health Dialogue for primary prevention of obesity in Child Health Services – a feasibility study

Aims: The aim of this study was to test a Child-Centred Health Dialogue model for primary prevention of obesity for 4-year-old children in Child Health Services, for its feasibility and the responsiveness of its outcomes. Methods: A feasibility study was set up with a non-randomised quasi-experimental cluster design comparing usual care with a structured multicomponent Child-Centred Health Dialogu

Field analyses for determination of material parameters - experimental and numerical aspects : Proceedings of the IUTAM Symposium held in Abisko National Park, Kiruna, Sweden, July 31 - August 4, 2000

The need for modelling of materials behaviour under various mechanical conditions is driven by the evolution of computer capacity and the ability of scientists to address complex mechanical problems. Reliable models for materials behaviour, including accurate numerical values of parameters, are necessary for a continued beneficial development of the computational side of solid mechanics. High rate

Women with a predisposition for diabetes have an increased risk of pregnancy complications, especially in combination with pregestational overweight

BACKGROUND: Overweight and gestational diabetes are risk factors for pregnancy complications. We hypothesized that the metabolic impact of overweight on pregnancy outcome, would be different if it was combined with a predisposition for diabetes. The aim of this study was to compare the outcome of pregnancies in women with diabetes diagnosed later in life, to the outcome of pregnancies of women who

Traumatic Peripheral Nerve Injuries : Experimental Models for Repair and Reconstruction

Peripheral nerve injuries are difficult to treat, and the clinical outcome after surgical repair and reconstruction is still insufficient, particularly concerning recovery of sensory function. To improve the clinical treatment strategies, experimental models are used to systematically examine the mechanisms behind nerve regeneration and assess the improvement of nerve regeneration by introduction

Burnout among school teachers : quantitative and qualitative results from a follow-up study in southern Sweden

BACKGROUND: Teachers are at high risk of stress-related disorders. This longitudinal study aimed to (a) identify which occupational, sociodemographic and life-style factors and self-efficacy at baseline that were of importance for burnout, (b) explore associations between changes in the studied factors versus changes in burnout, and (c) by interviews increase the understanding of perceived job dem

May Measurement Month 2018 : a pragmatic global screening campaign to raise awareness of blood pressure by the International Society of Hypertension

AIMS: Raised blood pressure (BP) is the biggest contributor to mortality and disease burden worldwide and fewer than half of those with hypertension are aware of it. May Measurement Month (MMM) is a global campaign set up in 2017, to raise awareness of high BP and as a pragmatic solution to a lack of formal screening worldwide. The 2018 campaign was expanded, aiming to include more participants an

Branched InAs nanowire growth by droplet confinement

Anisotropy in crystal growth of III-V semiconductor nanowires can be enhanced by the assistance of a liquid particle. During the past decades, selected scientific works have reported a controlled change in the nanowire growth direction by manipulation of the assisting droplet. Although these results are interesting from an engineering point of view, a detailed understanding of the process is neces

Kinetic Engineering of Wurtzite and Zinc-Blende AlSb Shells on InAs Nanowires

Using AlSb as the model system, we demonstrate that kinetic limitations can lead to the preferential growth of wurtzite (WZ) AlSb shells rather than the thermodynamically stable zinc-blende (ZB) AlSb and that the WZ and ZB relative thickness can be tuned by a careful control of the deposition parameters. We report selective heteroepitaxial radial growth of AlSb deposited by metal-organic vapor pha

Active NET formation in Libman–Sacks endocarditis without antiphospholipid antibodies : A dramatic onset of systemic lupus erythematosus

Although neutrophil extracellular traps (NETs) have been highlighted in several systemic inflammatory diseases, their clinical correlates and potential pathological role remain obscure. Herein, we describe a dramatic onset of systemic lupus erythematosus (SLE) with clear-cut pathogenic implications for neutrophils and NET formation in a young woman with cardiac (Libman–Sacks endocarditis) and cent

Do We Know What We Are Doing? An Exploratory Study on Swedish Health Economists and the EQ-5D

The UK tariff for quality of life associated with the health states in the EQ-5D is probably not consistent with the preferences of Swedish health economists. This is worrying in view of the widespread use of the tariff values and the fact that health economists likely are better able than ordinary citizens to report their preferences for health states in a valid and reliable manner. We suggest th

Trafiksäkerhetsutvärdering av nya trafikregler för cykelöverfarter

I september 2014 infördes en ny korsningstyp, cykelöverfart, där fordonstrafik som korsar cykelöverfarten har väjningsplikt mot cyklande och mopedförare som är på eller just på väg ut på cykelöverfarten. Syftet med projektet är att utvärdera regleringsformens effekt på cyklisters trafiksäkerhet. På tre platser i Malmö studerades hastigheter, allvarliga konflikter, väjningsbeteende samt interaktion