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The PDE3 enzymes or "low Kin cGMP-inhibited phosphodiesterases" have long been established as important mediators of cellular physiology, and synthetic PDE3 inhibitors have been critical to the delineation of the enzymes' roles. Yet despite decades of progress on the biology of these enzymes, the medicinal chemistry landscape relating to PDE3 inhibitors has remained essentially unchanged since the
A system for interstitial photodynamic therapy with delta-aminolaevulinic acid and multiple optical fibers has been developed. The system enables photodynamic treatment of large embedded tumor volumes and utilizes real-time measurements to allow on-line dosimetry. Important parameters such as light fluence rate, sensitizer fluorescence intensity, and changes in local blood oxygen saturation are me
Gaussian wave models have been successfully used since the early 1950s to describe the development of random sea waves, particularly as input to dynamic simulation of the safety of ships and offshore structures. A drawback of the Gaussian model is that it produces stochastically symmetric waves, which is an unrealistic feature and can lead to unconservative safety estimates. The Gaussian model des
We present a software solution that enables faster and more accurate data analysis of 2DE/MALDI TOF MS data. The software supports data analysis through a number of automated data selection functions and advanced graphical tools. Once protein identities are determined using MALDI TOF MS, automated data retrieval from online databases provides biological information. The software, called 2DDB, redu
This paper deals with the problem of finding a model for industrially manufactured fin-and-tube heat exchangers to determine the heat transfer for the complete fin-and-tube heat exchanger. The model is based on the temperature efficiency of the gas. The thermal conductance of the contact area between the fins and tubes is taken into consideration in the model. The influence of the fact that for in
BACKGROUND: The method of treatment of aortic valve stenosis in early infancy is still controversial. This study was performed to evaluate short-term and long-term outcome in our center during a 14-year period.METHODS: Between 1991 and 2004, 64 consecutive patients younger than 3 months old underwent open surgical commissurotomy because of aortic valve stenosis. Median age was 18 days (range, 1 to
The hallmark of severe haemophilia, defined as a circulating level of factor (F) VIII (haemophilia A cases) or FIX (haemophilia B cases) of < 1%, is recurrent bleeding into muscles and joints (haemarthroses) from an early age of life. The inevitable result of such bleeding is progressive joint damage, leading to disabling arthritis that is typically evident within the first 2 decades of life in pe
Powdery mildew is a common disease of field pea, Pisum sativum L., and is caused by the ascomycete fungus Erysiphe pisi. It can cause severe damage in areas where pea is cultivated. Today breeders want to develop new pea lines that are resistant to the disease. To make the breeding process more efficient, it is desirable to find genetic markers for use in a marker-assisted selection (MAS) strategy
We have studied a phosphate rock plant which produces dicalcium phosphate (DCP), used as a source of calcium and phosphorus for domestic animals. A by-product in the manufacturing process is calcium chloride which is used in the oil industry, the food industry and as road-salt. The objectives of our study were to describe the fluxes of radionuclides from the U-238 decay series and to estimate the
The purpose of this study was to assess, for the first time, the presence of muramic acid (Mur) and 3-hydroxy fatty acids (3-OH FAs), chemical markers for terrestrial bacteria in "curated" lunar samples by use of state-of-the-art gas chromatography-tandem mass spectrometry. The Apollo lunar sample collection has been stored, under isolation conditions, at the Johnson Space Center since 1969. Marke
The performance of the ALICE detector in searches for new heavy stable charged particles in pp collisions is discussed in this paper Gluino R-hadron was chosen as an example of a candidate, and cross sections and kinematic properties were obtained from PYTHIA simulations for various gluino masses (100 - 500 GeV/c(2)) Detector response simulations for R-hadrons in the TPC acceptance (vertical bar e
A set of simple analytical equations, derived from the Flory-Huggins theory, are used to identify the dominant driving forces for phase separation and solute (e.g., protein) partitioning, in the absence and presence of added electrolyte, in every general class of aqueous two-phase systems. The resulting model appears to capture the basic nature of two-phase systems and all trends observed experime
Popular Abstract in Swedish Under senare tid har hävdats att den IT/media-drivna så kallade "nya ekonomin" starkt etablerats. Enligt många påverkar IT/media teknologier marknadsföring och affärsverksamheter på ett 'revolutionerande' sätt. Denna avhandling behandlar kritiskt och strategiskt konstruktionen av värdeskapande affärserbjudanden där IT/media används. Vidare utvecklar författaren grundlägThis dissertation addresses the design of value productive episodes at the customer/firm boundary. Its purpose is: To provide perspective and help articulate strategies for increasing precision of the design of interactive marketing and value productive efforts at firm/customer boundaries. Many observers, thinkers and practitioners of marketing and management are: (1) Struggling to comprehend and
A critical assessment of a widely applied approach for the prediction of temperature-insensitive absorption lines is presented. This approach was found to suffer from significant shortcomings.
The major challenge in the development of new polymer membranes for fuel cells lies currently in the demand for durable membranes that allows fuel cell operation at high temperatures without extensive humidification requirements. Access to these membranes promises important benefits concerning the complexity, cost and performance of the fuel cell system. In this context, membranes functionalized w
We consider the decoding of LDPC codes in presence of non-Gaussian noise, especially a set of ¿-mixture models. For each of these models, the optimal LLRs are presented. We study the performance degradation due to the use of incorrect LLR in presence of a given noise model. Without modifying the existing LDPC decoder, we propose robust initial LLR which require minimum knowledge about the underly
The paper deals with various initiatives undertaken, or to be undertaken, by Government of Botswana, and which may be looked upon as "Information Society" initiatives. These initiatives are critically analysed and conclusions are drawn from the authors' analysis. Based on conclusions, the authors make certain recommendations regarding implementation of the initiatives.
We present the first results from several ongoing studies of the stellara bundances, ages, and chemical trends in the long-lived dwarf stars in the solar neighborhood that belong to the thin and thick galactic disk.We confirm that the trends of α-elements in the thin and thick disk are distinct, and we also find that the thick disk show the typical signature of SN Ia contribution to the chemical e
